The Emerging Field of Regenerative Aesthetics—Where We Are Now

Abstract

BACKGROUND Regenerative aesthetics is an emerging branch of regenerative medicine with therapies aimed at recapturing youthful structure and function using the body's own systems. OBJECTIVE To introduce the field of regenerative aesthetics, and to explore themes and evidence surrounding current and emerging therapies in the field. MATERIALS AND METHODS A review of the literature was performed for each of the 3 pillars of regeneration; namely, stem cells, biochemical cues, and scaffolds. RESULTS Herein, we provide an overview of the field of regenerative aesthetics, a discussion surrounding the 3 pillars of regeneration, and an overview of the evidence supporting current and emerging therapeutic modalities that could play a pivotal role in the future of aesthetic treatments. CONCLUSION An enhanced understanding of this field can serve to further enhance our awareness about the regenerative effects of therapies we already offer, in addition to providing inspiration for future innovation.

The evolving field of regenerative aesthetics

“…Misha et al set out 3 key regenerative treatment approaches recognized in RM and translated into RA. These key approaches are the use of cells, bio‐cues, and scaffolds, each providing a unique potential regenerative pathway 2 . The use of cells and, in particular, stem cells or tissue fractions containing stem cells such as stromal vascular fraction (SVF) has been established in aesthetics practice with a particular focus on autologous adipose stem cells or fractions combined with fat transfers in surgical procedures 3 ; however, this paper will focus primarily on non‐surgical treatment approaches.…”

“…These key approaches are the use of cells, bio-cues, and scaffolds, each providing a unique potential regenerative pathway. 2 The use of cells and, in particular, stem cells or tissue fractions containing stem cells such as stromal vascular fraction (SVF) has been established in aesthetics practice with a particular focus on autologous adipose stem cells or fractions combined with fat transfers in surgical procedures 3 ; however, this paper will focus primarily on non-surgical treatment approaches. "Bio-cues" is a collective term for a diverse set of treatment approaches which aim to improve the microenvironment of local tissue through cell signaling.…”

Skin regeneration-related mechanisms of Calcium Hydroxylapatite (CaHA): a systematic review

“…Skin aging is a common phenomenon in which the skin can no longer maintain normal thickness, strength, function, and hair density. By affecting different cell mechanisms, such as collagen synthesis, elastin production and angiogenesis, it is possible to stimulate regeneration in senescent tissue, an emerging concept referred to as regenerative aesthetics (2). Several such mechanisms have been suggested to support CaHA as a regenerative aesthetic treatment.…”

The Role of Calcium Hydroxylapatite (Radiesse) as a Regenerative Aesthetic Treatment: A Narrative Review

“…Regenerative aesthetics can be defined as a branch of regenerative medicine with therapies aimed at recapturing the youthful structure and function of tissue by exploiting the body's own systems. 3 Some regenerative aesthetic treatments are biologically derived. For example, stem cells, stromal vascular fraction, exosomes and extracellular vesicles, growth factors, platelet-rich plasma and fibrin, and allograft adipose matrices are becoming increasingly common treatment options in aesthetics.…”

“…For example, stem cells, stromal vascular fraction, exosomes and extracellular vesicles, growth factors, platelet-rich plasma and fibrin, and allograft adipose matrices are becoming increasingly common treatment options in aesthetics. 3 , 4 Some injectable fillers containing exogenous materials have been repeatedly shown to drive endogenous ECM regeneration. 5 Injectable treatments offer the ability to augment and regenerate soft tissue in a minimally invasive manner with minimal downtime.…”