The Emerging Landscape of Long Non-Coding RNAs in Colorectal Cancer Metastasis

Liao, Zhiming; Nie, Hui; Wang, Yutong; Luo, Jingjing; Zhou, Jianhua; Ou, Chunlin

doi:10.3389/fonc.2021.641343

Cited by 25 publications

(23 citation statements)

References 232 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Involvement of a variety of genetic and epigenetic changes has been reported in CRC initiation and progression (Okugawa et al, 2015;Siskova et al, 2020). LncRNAs have been reported to play important roles in epigenetic alterations, revealing their potential as novel targets for CRC prevention and treatment (Chen et al, 2021;Liao et al, 2021). Gong et al (2019) found that CRC patients in stages I-II presented with lower levels of tumor DUXAP8 than those in stage III-IV, and patients with larger tumor sizes expressed higher levels of DUXAP8.…”

Section: Colorectal Cancermentioning

confidence: 99%

Long Non-coding RNA Double Homeobox A Pseudogene 8: A Novel Oncogenic Propellant in Human Cancer

Xue

Cai

Jia

2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

A growing number of studies are reporting important roles played by long non-coding RNAs (lncRNAs) in various pathological and physiological processes. LncRNAs are implicated in numerous genomic regulatory functions at different levels, including regulation of transcription, post-transcriptional processes, genomic stability, and epigenetic genome modifications. Double homeobox A pseudogene 8 (DUXAP8), a novel lncRNA, has been reported to be involved in many cancers, including gastric, colorectal, esophageal, bladder, oral, ovarian, lung, and pancreatic cancers as well as hepatocellular carcinoma (HCC). DUXAP8 plays specific oncogenic roles via numerous malignancies promoting pathways. DUXAP8 is frequently dysregulated in multiple cancers, acting as a sponge to downregulate various tumor-suppressing microRNA activities. In this review, we comprehensively explore DUXAP8 expression and prognosis across cancer types, and systematically summarize current evidence concerning the functions and molecular mechanisms of DUXAP8 in tumorigenesis and progression. We conclude that DUXAP8 is a potential biomarker and therapeutic target for multiple cancers.

show abstract

Section: Colorectal Cancermentioning

confidence: 99%

Long Non-coding RNA Double Homeobox A Pseudogene 8: A Novel Oncogenic Propellant in Human Cancer

Xue

Cai

Jia

2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…The previous studies have indicated that many lncRNAs are dysregulated in cancers (Iyer et al, 2015;Yan et al, 2015). Aberrant expression of lncRNAs is associated with tumor growth (Zhou et al, 2020), metastasis (Liao et al, 2021), angiogenesis (Jin et al, 2020), chemotherapy resistance (Ferretti and León, 2021), and metabolism (Xu et al, 2021). Therefore, lncRNAs are regarded as important regulators of the pathological processes in cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Long Non-coding RNA DANCR in Cancer: Roles, Mechanisms, and Implications

Wang

Zhang

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Long non-coding RNA (lncRNA) DANCR (also known as ANCR)—differentiation antagonizing non-protein coding RNA, was first reported in 2012 to suppress differentiation of epithelial cells. Emerging evidence demonstrates that DANCR is a cancer-associated lncRNA abnormally expressed in many cancers (e.g., lung cancer, gastric cancer, breast cancer, hepatocellular carcinoma). Increasing studies suggest that the dysregulation of DANCR plays critical roles in cancer cell proliferation, apoptosis, migration, invasion, and chemoresistance in vitro and tumor growth and metastasis in vivo. Mechanistic analyses show that DANCR can serve as miRNA sponges, stabilize mRNAs, and interact with proteins. Recent research reveals that DANCR can be detected in many body fluids such as serum, plasma, and exosomes, providing a quick and convenient method for cancer monitor. Thus DANCR can be used as a promising diagnostic and prognostic biomarker and therapeutic target for various types of cancer. This review focuses on the role and mechanism of DANCR in cancer progression with an emphasis on the clinical significance of DANCR in human cancers.

show abstract

“…Since colorectal cancer is a multifactorial disease, studies aiming to reveal the molecular changes associated with this type of cancer can provide potential preventative and therapeutic strategies for this disease [26][27][28]. In colorectal cancer, a few lncRNAs have been identified as potential diagnostic and therapeutic targets [29,30]. In present study, we found that SNHG10 expression was up-regulated in colorectal cancer, and downregulation of SNHG10 inhibited the ability of HCT116 and DXH-1 cells proliferation, migration and invasion.…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA SNHG10 promotes colorectal cancer cells malignant progression by targeting miR-3690

et al. 2021

View full text Add to dashboard Cite

Long noncoding RNA small nucleolar RNA host gene 10 (SNHG10) has been suggested to function as tumor promoter in various human cancer types. Herein, the role of SNHG10 in colorectal cancer (CRC) was explored. Expression levels of genes in colorectal cancer tissues and cell lines were detected by Starbase and reverse transcription quantitative PCR (RT-qPCR) Cell Counting Kit-8 (CCK-8), the BrdU incorporation assay and Transwell assays were explored to study the function of SNHG10 in HCT116 and DXH-1 cells. In addition, the interaction of SNHG10 and miR-3690 was analyzed by dual-luciferase reporter assays. SNHG10 had a high expression level in CRC tissues and cell lines. Meanwhile, knockdown of SNHG10 reduced cell viability, inhibited cell proliferation and decreased cell migration and invasion. Moreover, bioinformatics analysis revealed that one potential target gene of SNHG10 was miR-3690. Dual-luciferase reporter assay confirmed that miR-3690 directly targeted SNHG10. Importantly, SNHG10 could decrease the expression of miR-3690 in HCT116 and DXH-1 cells. More importantly, the silencing of miR-3690 reversed the effect of the SNHG10 knockdown on the cell viability, proliferation, migration and invasion of HCT116 and DXH-1 cells. The present results demonstrated that SNHG10 promotes colorectal cancer cells the malignant progression by targeting miR-3690.

show abstract

The Emerging Landscape of Long Non-Coding RNAs in Colorectal Cancer Metastasis

Cited by 25 publications

References 232 publications

Long Non-coding RNA Double Homeobox A Pseudogene 8: A Novel Oncogenic Propellant in Human Cancer

Long Non-coding RNA Double Homeobox A Pseudogene 8: A Novel Oncogenic Propellant in Human Cancer

Long Non-coding RNA DANCR in Cancer: Roles, Mechanisms, and Implications

Long noncoding RNA SNHG10 promotes colorectal cancer cells malignant progression by targeting miR-3690

Contact Info

Product

Resources

About