The emerging regulatory roles of long non-coding RNAs implicated in cancer metabolism

Xu, Yongcan; Qiu, Mantang; Shen, Minmin; Dong, Shunli; Ye, Guochao; Shi, Xuefei; Sun, Ming

doi:10.1016/j.ymthe.2021.03.017

Cited by 46 publications

(37 citation statements)

References 113 publications

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“…The previous studies have indicated that many lncRNAs are dysregulated in cancers (Iyer et al, 2015;Yan et al, 2015). Aberrant expression of lncRNAs is associated with tumor growth (Zhou et al, 2020), metastasis (Liao et al, 2021), angiogenesis (Jin et al, 2020), chemotherapy resistance (Ferretti and León, 2021), and metabolism (Xu et al, 2021). Therefore, lncRNAs are regarded as important regulators of the pathological processes in cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Long Non-coding RNA DANCR in Cancer: Roles, Mechanisms, and Implications

Wang

Zhang

et al. 2021

Front. Cell Dev. Biol.

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Long non-coding RNA (lncRNA) DANCR (also known as ANCR)—differentiation antagonizing non-protein coding RNA, was first reported in 2012 to suppress differentiation of epithelial cells. Emerging evidence demonstrates that DANCR is a cancer-associated lncRNA abnormally expressed in many cancers (e.g., lung cancer, gastric cancer, breast cancer, hepatocellular carcinoma). Increasing studies suggest that the dysregulation of DANCR plays critical roles in cancer cell proliferation, apoptosis, migration, invasion, and chemoresistance in vitro and tumor growth and metastasis in vivo. Mechanistic analyses show that DANCR can serve as miRNA sponges, stabilize mRNAs, and interact with proteins. Recent research reveals that DANCR can be detected in many body fluids such as serum, plasma, and exosomes, providing a quick and convenient method for cancer monitor. Thus DANCR can be used as a promising diagnostic and prognostic biomarker and therapeutic target for various types of cancer. This review focuses on the role and mechanism of DANCR in cancer progression with an emphasis on the clinical significance of DANCR in human cancers.

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Section: Introductionmentioning

confidence: 99%

Long Non-coding RNA DANCR in Cancer: Roles, Mechanisms, and Implications

Wang

Zhang

et al. 2021

Front. Cell Dev. Biol.

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“…[1][2][3][4] The latter is currently the main topic of several scientific investigations as they are still poorly known, even though they account for many cellular regulatory functions, and their dysregulation is often associated with pathologic conditions 5 such as degenerative diseases and cancers. [6][7][8][9] Recently, it has been proposed an alternative classification of the large family of the lncRNA, although still not widely used: the imprinted lncRNAs, controlling the expression of imprinted genes 10 ; the disease-associated lncRNAs, correlated with particular pathological conditions [11][12][13] ; the pathogen-induced lncRNAs, secreted and modulated by exogenous microorganisms 14 ; the bifunctional RNAs that might be also translated into proteins 15 ; the molecular sponges that interfere with the activity of miRNAs reducing their cellular bioavailability 16 ; the circular RNAs (circRNAs) 17 ; the large intergenic non-coding RNAs (lincRNAs), which control gene expression through histone modifications. 18 Long non-coding small nucleolar RNA host genes (lnc-SNHGs), the host genes for snoRNAs, are overexpressed in human cancers.…”

Section: Introductionmentioning

confidence: 99%

Small nucleolar RNA host genes promoting epithelial–mesenchymal transition lead cancer progression and metastasis

Biagioni¹,

Tavakol

Ahmadirad

et al. 2021

IUBMB Life

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The small nucleolar RNA host genes (SNHGs) belong to the long non-coding RNAs and are reported to be able to influence all three levels of cellular information-bearing molecules, that is, DNA, RNA, and proteins, resulting in the generation of complex phenomena. As the host genes of the small nucleolar RNAs (snoRNAs), they are commonly localized in the nucleolus, where they exert multiple regulatory functions orchestrating cellular homeostasis and differentiation as well as metastasis and chemoresistance. Indeed, worldwide literature has reported their involvement in the epithelial-mesenchymal transition (EMT) of different histotypes of cancer, being able to exploit peculiar features, for example, the possibility to act both in the nucleus and the cytoplasm. Moreover, SNHGs regulation is a fundamental topic to better understand their role in tumor progression albeit such mechanism is still debated. Here, we reviewed the biological functions of SNHGs in particular in the EMT process and discussed the perspectives for new cancer therapies.

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“…Long non-coding RNAs (lncRNAs) are RNA transcripts (> 200 nucleotides) with limited coding potential [ 7 ] that are abnormally expressed in all stages of cancer development and play vital regulatory roles in oncogenic processes [ 8 ]. A recent study reported that lncRNA dysregulation is closely related to tumor metabolic reprogramming [ 9 ]. Further work is needed to identify glycolysis-related-lncRNAs in NSCLC and clarify their potential roles and specific mechanisms.…”

Section: Introductionmentioning

confidence: 99%

AL355338 acts as an oncogenic lncRNA by interacting with protein ENO1 to regulate EGFR/AKT pathway in NSCLC

et al. 2021

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Background Non-small cell lung cancer (NSCLC) is a malignancy with considerable morbidity and mortality. Abnormal metabolism is a hallmark of cancer; however, the mechanism of glycolysis regulation in NSCLC progression is not completely understood. Recent studies suggest that some dysregulated long non-coding RNAs (lncRNAs) play important roles in tumor metabolic reprogramming. Methods To identify glycolysis-associated-lncRNAs in NSCLC, we compared RNA-sequencing results between high 18F-fluorodeoxyglucose (FDG)-uptake NSCLC tissues and paired paratumor tissues. The transcript abundance of AL355338 in 80 pairs of clinical samples was evaluated by quantitative real-time PCR assay and fluorescence in situ hybridization. The biological role of AL355338 on NSCLC cells were evaluated by functional experiments in vitro and in vivo. Moreover, RNA pull-down, mass spectrometry and RNA immunoprecipitation (RIP) assays were used to identify the protein interacted with AL355338. Co-immunoprecipitation, in situ proximity ligation assays and western blotting were applied to define the potential downstream pathways of AL355338. Results AL355338 was an upregulated glycolysis-associated lncRNA in NSCLC. Functional assays revealed that AL355338 was critical for promoting aerobic glycolysis and NSCLC progression. Mechanistic investigations showed that AL355338 directly bound with alpha-enolase (ENO1) and enhanced the protein’s stability by modulating its degradation and ubiquitination. A positive correlation was observed between AL355338 and ENO1 in NSCLC, and ENO1 was subsequently confirmed to be responsible for the oncogenic role of AL355338. Furthermore, AL355338 was capable of modulating ENO1/EGFR complex interaction and further activating EGFR-AKT signaling. Conclusions This study indicates that AL355338 confers an aggressive phenotype to NSCLC, and targeting it might be an effective therapeutic strategy.

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The emerging regulatory roles of long non-coding RNAs implicated in cancer metabolism

Cited by 46 publications

References 113 publications

Long Non-coding RNA DANCR in Cancer: Roles, Mechanisms, and Implications

Long Non-coding RNA DANCR in Cancer: Roles, Mechanisms, and Implications

Small nucleolar RNA host genes promoting epithelial–mesenchymal transition lead cancer progression and metastasis

AL355338 acts as an oncogenic lncRNA by interacting with protein ENO1 to regulate EGFR/AKT pathway in NSCLC

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