The emerging role of adipokines in osteoarthritis: a narrative review

Hu, Pengfei; Bao, Jiapeng; Wu, Lidong

doi:10.1007/s11033-010-0179-y

Cited by 78 publications

(55 citation statements)

References 80 publications

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“…Considerably strong and growing evidence supports the important role of various adipokines in OA (Hu et al 2011;Conde et al 2011). Adipokines were also viewed as a potential metabolic factor which link obesity to OA (Gabay and Berenbaum 2009).…”

Section: Discussionmentioning

confidence: 99%

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Circulating levels of adiponectin, resistin, and visfatin after mud-bath therapy in patients with bilateral knee osteoarthritis

et al. 2015

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Adipocytokines, including adiponectin, resistin, and visfatin may play an important role in the pathophysiology of osteoarthritis (OA). Spa therapy is one of the most commonly used non-pharmacological approaches for OA, but its mechanisms of action are not completely known. The aim of the present study was to assess whether a cycle of mud-bath therapy (MBT) influences the serum levels of adiponectin, resistin, and visfatin in patients with knee OA. As part of a prospective randomized, single blind-controlled trial evaluating the efficacy of MBT in knee OA, we included in this study 95 outpatients. One group (n = 49) received a cycle of MBT at the spa center of Chianciano Terme (Italy) in addition to the usual treatment, and one group (control group; n = 46) continued their regular care routine alone. Patients were assessed at basal time and at the end of the study (15 days) for clinical and biochemical parameters. Clinical assessments included spontaneous pain on a visual analog scale (VAS) score and the Western Ontario and McMaster Universities index (WOMAC) subscores for knee OA evaluated as total pain score (W-TPS), total stiffness score (W-TSS), and total physical function score (W-TPFS). Adiponectin, resistin and visfatin serum levels were assessed by enzyme immunoassay methods. At the end of the mud-bath therapy, serum adiponectin levels showed a significant decrease (p < 0.001), while no significant modifications were found in the control group at day 15. Serum resistin showed a significant decrease (p < 0.0001) in the MBT group at the end of the study and a significant increase in the control patients (p < 0.001). No significant modifications of visfatin were found in MBT. Furthermore, we tested the relationships between demographic and clinical parameters and adipocytokine concentrations measured in the MBT group at basal and at the end of the study. In conclusion, the present study shows that a cycle of MBT can modify serum levels of adiponectin and resistin but not the circulating levels of visfatin. In view of the recent evidences about the involvement of adiponectin and resistin in the pathogenesis and progression of OA, the decrease of these adipokines after mud-bath therapy may play a protective role in the course of the disease. However, it remains to be clarified which of the mechanisms of action of MBT may have determined the changes in serum levels of adiponectin and resistin that we observed.

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Section: Discussionmentioning

confidence: 99%

“…Visfatin has proinflammatory and immunomodulating functions (Sun et al 2013) and manifested a pro-degradative effect in cartilage by i n c r e a s i n g t h e s y n t h e s i s o f M M P -3 , M M P -1 3 , thrombospondin motifs (ADAMTS)-4, and ADAMTS-5 (Gosset et al 2008;Hu et al 2011;Laiguillon et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Circulating levels of adiponectin, resistin, and visfatin after mud-bath therapy in patients with bilateral knee osteoarthritis

et al. 2015

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“…The role of adiponectin played in the inflammatory process is not completely elucidated. It was suggested that it affects IL-1β, IL-6, MMP-13 [39], MMP-1, MMP-3, NO [38], and MMP-9 secretion [40].…”

Section: Adiponectinmentioning

confidence: 99%

The role of adipocytokines in the pathogenesis of knee joint osteoarthritis

Richter

Trzeciak

Owecki

et al. 2015

International Orthopaedics (SICOT)

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Osteoarthritis (OA) is one of the most common causes of musculoskeletal disability in the world. Traditionally, it has been thought that obesity contributes to the development and progression of OA by increased mechanical load of the joint structures. Nevertheless, studies have shown that adipose tissue-derived cytokines (adipocytokines) are a possible link between obesity and OA. Furthermore, according to recent findings, not only articular cartilage may be the main target of these cytokines but also the synovial membrane, subchondral bone and infrapatellar fat pad may be encompassed in the process of degradation. This review presents the most recent reports on the contribution of adipocytokines to the knee joint cartilage degradation, osteophyte formation, infrapatellar fat pad alterations and synovitis.

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“…Accordingly, reduced plasma levels of adiponectin are reported to be associated with an increased risk in developing insulin resistance, type 2 diabetes mellitus (T2DM), obesity, metabolic syndrome, and even osteoarthritis (Kadowaki et al, 2006;Matsuzawa et al, 2004;Weyer et al, 2001;Daimon et al, 2003;Hu et al, 2011). The protective effect of adiponectin against these metabolic phenotypes may involve the suppression of hepatic gluconeogenesis, stimulation of fatty acid oxidation in the liver, stimulation of fatty acid oxidation and glucose uptake in the muscle and the stimulation of insulin secretion (Rabe et al, 2008).…”

Section: Introductionmentioning

confidence: 99%