The Emerging Role of Circ-SHPRH in Cancer

Abstract

Purpose: Circ-SHPRH is a circular RNA that can regulate the expression of target genes by sponging microRNAs (miRNAs) or translating tumor suppressor proteins. Recent studies have suggested that circ-SHPRH may play a role in the development of tumors and cancers. Hence, this paper aimed to review the biological characteristics, molecular mechanisms, and potential clinical significance of circ-SHPRH in a variety of tumors and to evaluate its potential as a new diagnostic and prognostic biomarker. Methods: Numerous experiments were performed regarding the abnormal expression of circ-SHPRH in a variety of tumors, including hepatocellular carcinoma, gastric carcinoma, non-small cell lung cancer, osteosarcoma, colorectal cancer, cholangiocarcinoma, pancreatic ductal adenocarcinoma, retinoblastoma, and glioblastoma. Results: Upregulation of circ-SHPRH reportedly inhibits tumor cell proliferation, migration, and invasion, leading to the inhibition of tumor development. The clinicopathological parameters and the functional characteristics of circ-SHPRH in multiple human tumors and cancers were summarized. Circ-SHPRH functions as a tumor suppressor gene and has great potential as a diagnostic and prognostic biomarker for different types of cancer.

Integrative genomics identifies SHPRH as a tumor suppressor gene in lung adenocarcinoma that regulates DNA damage response

“…However, while it was suggested that this protein operated by protecting the full-length SHPRH protein from degradation, no further investigation was done on the function of full-length SHPRH itself in glioblastoma [93]. Similarly, while there has been a recent emergence of evidence suggesting that circ-SHPRH operates as a tumor suppressor gene in a multitude of other cancerswhere its downregulation in turn promotes cancer development and progression by affecting a variety of oncogenic processesthe evaluation of its effect on full-length SHPRH in these cancers has yet to be conducted [94]. As such, despite the overwhelming evidence suggesting that full-length SHPRH may be a tumor suppressor in multiple cancer types, the functional characterization of it as a tumor suppressor gene has yet to be exhibited.…”

Knockdown of hsa_circ_0043691 restrains the progression of gastric cancer by decoying miR‐1294 to target pre‐leukemia transcription factor 3

“…It has been previously found that circRNAs play vital effects in various cancer progression, including GC. 20 For example, overexpression of circHECTD1 advanced GC cell malignant phenotype by energizing glutaminolysis metabolites. 21 Circ_0002570 knockdown could suppress cell proliferation and metastasis in vitro, and restrain tumor growth in vivo.…”

“…It has been previously found that circRNAs play vital effects in various cancer progression, including GC 20 . For example, overexpression of circHECTD1 advanced GC cell malignant phenotype by energizing glutaminolysis metabolites 21 .…”