The emerging role of skeletal muscle extracellular matrix remodelling in obesity and exercise

Martinez-Huenchullan, Sergio F.; McLennan, Susan V.; Verhoeven, Adrie J.M.; Twigg, Stephen M.; Tam, Charmaine S.

doi:10.1111/obr.12548

Cited by 31 publications

(29 citation statements)

References 70 publications

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“…ECM in the intramuscular connective tissues maintains tissue integrity and regulates passive mechanical properties of the skeletal muscle . Contractile activity induces collagen synthesis, which helps in skeletal muscle remodelling in response to functional demand . On the contrary, mechanical unloading of skeletal muscle results in reduced synthesis of muscle collagen at the post‐translational levels .…”

Section: Methodsmentioning

confidence: 99%

“…141 Contractile activity induces collagen synthesis, which helps in skeletal muscle remodelling in response to functional demand. 142 On the contrary, mechanical unloading of skeletal muscle results in reduced synthesis of muscle collagen at the post-translational levels. 143 Type I collagen is most affected, 143 although there is a significant reduction in the synthesis of type III 144,145 and IV 146 collagens as well.…”

Section: Extracellular Matrix (Ecm)mentioning

confidence: 99%

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Muscle unloading: A comparison between spaceflight and ground‐based models

2019

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Prolonged unloading of skeletal muscle, a common outcome of events such as spaceflight, bed rest and hindlimb unloading, can result in extensive metabolic, structural and functional changes in muscle fibres. With advancement in investigations of cellular and molecular mechanisms, understanding of disuse muscle atrophy has significantly increased. However, substantial gaps exist in our understanding of the processes dictating muscle plasticity during unloading, which prevent us from developing effective interventions to combat muscle loss. This review aims to update the status of knowledge and underlying mechanisms leading to cellular and molecular changes in skeletal muscle during unloading. We have also discussed advances in the understanding of contractile dysfunction during spaceflights and in ground‐based models of muscle unloading. Additionally, we have elaborated on potential therapeutic interventions that show promising results in boosting muscle mass and strength during mechanical unloading. Finally, we have identified key gaps in our knowledge as well as possible research direction for the future.

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Section: Methodsmentioning

confidence: 99%

Section: Extracellular Matrix (Ecm)mentioning

confidence: 99%

Muscle unloading: A comparison between spaceflight and ground‐based models

2019

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“…Endurance exercise training is associated with an increase in IMCLs, but not intermuscular adipose tissue (van Loon et al, 2004;Dubé et al, 2008). Furthermore, acute resistance and endurance exercise is known to increase muscle extracellular matrix synthesis with a similar increase in breakdown resulting in matrix remodeling without excessive accumulation, unlike pathological conditions (Martinez-Huenchullan et al, 2017). Using a preclinical model of radiation exposure, recent work from our group showed a differential FAP response of obese and exercise trained mice (D'Souza et al, 2019).…”

Section: Fibro/adipogenic Progenitors As the Cellular Source Of Intermentioning

confidence: 97%

Role of Metabolic Stress and Exercise in Regulating Fibro/Adipogenic Progenitors

Collao

Farup

Lisio

2020

Front. Cell Dev. Biol.

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Obesity is a major public health concern and is associated with decreased muscle quality (i.e., strength, metabolism). Muscle from obese adults is characterized by increases in fatty, fibrotic tissue that decreases the force producing capacity of muscle and impairs glucose disposal. Fibro/adipogenic progenitors (FAPs) are muscle resident, multipotent stromal cells that are responsible for muscle fibro/fatty tissue accumulation. Additionally, they are indirectly involved in muscle adaptation through their promotion of myogenic (muscle-forming) satellite cell proliferation and differentiation. In conditions similar to obesity that are characterized by chronic muscle degeneration, FAP dysfunction has been shown to be responsible for increased fibro/fatty tissue accumulation in skeletal muscle, and impaired satellite cell function. The role of metabolic stress in regulating FAP differentiation and paracrine function in skeletal muscle is just beginning to be unraveled. Thus, the present review aims to summarize the recent literature on the role of metabolic stress in regulating FAP differentiation and paracrine function in skeletal muscle, and the mechanisms responsible for these effects. Furthermore, we will review the role of physical activity in reversing or ameliorating the detrimental effects of obesity on FAP function.

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“…The ECM is a complex milieu of diverse structural molecules involved in structural support together with cellular signaling and tissue responses to diseases and injuries [ 16 ]. An organization of ECM molecules have their own distinct features and is responsible for the various biological activities [ 16 , 17 ]. A number of muscle-related genetically determined diseases are caused primarily by mutations in the ECM components and their receptors.…”

Section: Extracellular Matrixmentioning

confidence: 99%

Multifaceted Interweaving Between Extracellular Matrix, Insulin Resistance, and Skeletal Muscle

Ahmad

Lee

Moon

et al. 2018

Cells

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The skeletal muscle provides movement and support to the skeleton, controls body temperature, and regulates the glucose level within the body. This is the core tissue of insulin-mediated glucose uptake via glucose transporter type 4 (GLUT4). The extracellular matrix (ECM) provides integrity and biochemical signals and plays an important role in myogenesis. In addition, it undergoes remodeling upon injury and/or repair, which is also related to insulin resistance (IR), a major cause of type 2 diabetes (T2DM). Altered signaling of integrin and ECM remodeling in diet-induced obesity is associated with IR. This review highlights the interweaving relationship between the ECM, IR, and skeletal muscle. In addition, the importance of the ECM in muscle integrity as well as cellular functions is explored. IR and skeletal muscle ECM remodeling has been discussed in clinical and nonclinical aspects. Furthermore, this review considers the role of ECM glycation and its effects on skeletal muscle homeostasis, concentrating on advanced glycation end products (AGEs) as an important risk factor for the development of IR. Understanding this complex interplay between the ECM, muscle, and IR may improve knowledge and help develop new ideas for novel therapeutics for several IR-associated myopathies and diabetes.

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The emerging role of skeletal muscle extracellular matrix remodelling in obesity and exercise

Cited by 31 publications

References 70 publications

Muscle unloading: A comparison between spaceflight and ground‐based models

Muscle unloading: A comparison between spaceflight and ground‐based models

Role of Metabolic Stress and Exercise in Regulating Fibro/Adipogenic Progenitors

Multifaceted Interweaving Between Extracellular Matrix, Insulin Resistance, and Skeletal Muscle

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