The Encapsulation of Metformin on Chitosan Matrix as Diabetes Mellitus Drug Slow Release System

Abstract

This study was aimed to encapsulation metformin, the diabetes melittus type 2 drugs. In this study, chitosan-alginat and tween 80 composites were used as matrix encapsulation. The chitosan was mixed with variation of the composition of metformin-calcium alginate-tween 80. The effectivity of encapsulation was evaluated from surface morphology, functional group, % drug encapsulation efficiency and effect soaked on stability encapsulation. The metformin encapsulated was characterized to analysis of the functional group and particle size. The results showed that the metformin encapsulated a slightly rough surface with a good appearance. The drug encapsulation efficiency was about 7.06 to 30.32 %.