The endocrine response to critical illness

Rolih, Catherine A.; Ober, K. Patrick

doi:10.1016/s0025-7125(16)30093-1

Cited by 79 publications

(34 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some prolonged stressful situations can trigger a complex endocrine response, with high plasmatic renin concentrations and no increase of aldosterone levels. 13,14 Chronic body potassium depletion may have an important inhibitory effect on the secretion of aldosterone by the zona glomerulosa of the adrenal glands. 15,16 Parasitism and atrophy of the cortical layers of the adrenal glands, especially of the zona glomerulosa, have been observed in histological studies, and can exert an additional influence in the adrenal response resulting in low aldosterone production even after renin and hypothalamus-pituitary-adrenal axis stimuli.…”

mentioning

confidence: 99%

Hormonal Disturbances in Visceral Leishmaniasis (Kala-Azar)

Verde¹,

Verde²,

Neto³

et al. 2011

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

This study presents a cross-sectional analysis of the hormonal alterations of patients with visceral leishmaniasis. The diagnosis was established by the bone marrow aspiration and polymerase chain reaction test. Primary adrenal insufficiency was observed in 45.8% of patients; low aldosterone/renin plasma ratio in 69.4%; low daily urinary aldosterone excretion in 61.1%; and low transtubular potassium gradient in 68.0%. All patients had normal plasma antidiuretic hormone (ADH) concentrations, hyponatremia, and high urinary osmolality. Plasma parathyroid hormone was low in 63%; hypomagnesemia was present in 46.4%, and increased Mg++EF in 100%. Primary thyroid insufficiency was observed in 24.6%, and secondary thyroid insufficiency in 14.1%. Normal follicle-stimulating hormone plasma levels were present in 81.4%; high luteinizing hormone and low testosterone plasma levels in 58.2% of men. There are evidences of hypothalamus-pituitary-adrenal axis abnormalities, inappropriate aldosterone and ADH secretions, and presence of hypoparathyroidism, magnesium depletion, thyroid and testicular insufficiencies.

show abstract

mentioning

confidence: 99%

Hormonal Disturbances in Visceral Leishmaniasis (Kala-Azar)

Verde¹,

Verde²,

Neto³

et al. 2011

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…Vor allem TNF ("tumor necrosis factor")-α und Interleukin-1β korrelieren mit dem Schweregrad der Erkrankung [27,30]. Durch diese Steuerung werden die Stoffwechselvorgänge von der Nahrungszufuhr abgekoppelt.…”

Section: Was Kann Eine Ernährungstherapie Bewirken?unclassified

Ernährung kritisch Kranker auf der Intensivstation

et al. 2007

View full text Add to dashboard Cite

A concept for combined enteral and parenteral nutrition for critically ill patients is described in which endogenous substrate production during the acute phase of illness is taken into consideration and hyperalimentation is avoided. The nutritional goal is defined by multiplication of the base rate, i.e. body weight (BW) in kg as delivery rate in ml/h (wedge 24 kcal/kg BW/24 h), with a target factor, which varies between 0.2 and 1.8. An equivalent composition of enteral and parenteral nutrition allows a transition between both forms without problems. Simultaneously, immunologic aspects of nutrition are considered as well and both forms of nutrition are complemented by immune-modulating substrates such as glutamine and antioxidants.

show abstract

“…La réponse neuroendocrinienne face à la maladie aiguë grave est évolutive, complexe et changeante, avec pour objectif de maintenir la vie. Des altérations hormonales importantes peuvent se produire et quelquefois les médecins peuvent les confondre avec des maladies endocriniennes [1][2][3]. L'axe neuroendocrinien peut être considéré comme un arc réflexe avec une voie afférente et efférente où le système nerveux central joue un rôle fondamental par l'intégration de stimuli de type neural (douleur, etc.…”

Section: ■ Résuméunclassified