1991
DOI: 10.1111/j.1471-0528.1991.tb13519.x
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The endometrial status of women on longterm continuous combined hormone replacement therapy

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Cited by 20 publications
(10 citation statements)
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“…7 – 10 12 13 17 19 This study confirms that long term treatment for up to five years with a continuous combined hormone replacement therapy regimen of oestradiol 2 mg and norethisterone acetate 1 mg daily was associated with neither endometrial hyperplasia nor malignancy and that it converted the endometrium to normal in women in whom complex hyperplasia arose during previous sequential or unopposed oestrogen regimens.…”
Section: Discussionsupporting
confidence: 66%
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“…7 – 10 12 13 17 19 This study confirms that long term treatment for up to five years with a continuous combined hormone replacement therapy regimen of oestradiol 2 mg and norethisterone acetate 1 mg daily was associated with neither endometrial hyperplasia nor malignancy and that it converted the endometrium to normal in women in whom complex hyperplasia arose during previous sequential or unopposed oestrogen regimens.…”
Section: Discussionsupporting
confidence: 66%
“…16 17 24 25 A separate study of 40 postmenopausal women treated with the same drug at one of the participating sites confirmed that the Pipelle method of sampling was effective and that an unassessable specimen was associated with endometrial atrophy 26…”
Section: Discussionmentioning
confidence: 92%
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“…All these regimens tend to produce an atrophic endometrium in the short term 54,60 ; we do not yet have information on effects on the endometrium in the long term. It is, however, reassuring that in women who develop complex endometrial hyperplasia after taking standard combined sequential regimens for a mean of 2–5 years 40 the endometrium is corrected to normal after changing to a continuous combined therapy preparation 61,62 .…”
Section: Continuous Combined Therapymentioning
confidence: 98%
“…The aim is to achieve amenorrhoea by rendering the endometrium atrophic 7. It is hoped that women who have been postmenopausal for many years and are used to not bleeding regularly will accept continuous combined therapies more readily than sequential ones.…”
Section: Introductionmentioning
confidence: 99%