The enigmatic role of growth hormone in age-related diseases, cognition, and longevity

Colon, Gabriela; Saccon, Tatiana D.; Schneider, Augusto; Cavalcante, Marcelo Borges; Huffman, Derek M.; Berryman, Darlene E.; List, Ed; Ikeno, Yuji; Musi, Nicolas; Bartke, Andrzej; Kopchick, John J.; Kirkland, James L.; Tchkonia, Tamara; Masternak, Michał M.

doi:10.1007/s11357-019-00096-w

Cited by 33 publications

(23 citation statements)

References 121 publications

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“…In humans, GH and IGF-1 levels peak during puberty, decline during aging [35], and coincide with unfavorable effects on mitochondrial metabolism in brain (cognition [36]), muscle (sarcopenia [2]), and skeletal tissue (osteopenia [1]). IGF-1 haploinsufficiency (IGF-1 +/− ) in mice was associated with mitochondrial dysfunction accompanied by increased level of lipid peroxidation, protein carboxylation, and intramitochondrial ROS in hepatocytes [37].…”

Section: Gh/ Igf-1 Effects On Mitochondrial Respiration and Atp Produmentioning

confidence: 99%

Effects of GH/IGF on the Aging Mitochondria

Poudel

Dixit

Neginskaya

et al. 2020

Cells

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The mitochondria are key organelles regulating vital processes in the eukaryote cell. A decline in mitochondrial function is one of the hallmarks of aging. Growth hormone (GH) and the insulin-like growth factor-1 (IGF-1) are somatotropic hormones that regulate cellular homeostasis and play significant roles in cell differentiation, function, and survival. In mammals, these hormones peak during puberty and decline gradually during adulthood and aging. Here, we review the evidence that GH and IGF-1 regulate mitochondrial mass and function and contribute to specific processes of cellular aging. Specifically, we discuss the contribution of GH and IGF-1 to mitochondrial biogenesis, respiration and ATP production, oxidative stress, senescence, and apoptosis. Particular emphasis was placed on how these pathways intersect during aging.

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Section: Gh/ Igf-1 Effects On Mitochondrial Respiration and Atp Produmentioning

confidence: 99%

Effects of GH/IGF on the Aging Mitochondria

Poudel

Dixit

Neginskaya

et al. 2020

Cells

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“…Interestingly, low IGF-1 levels have been associated with risk for vascular dementias (262). On the contrary, studies with growth hormone deficient (GHD) people and mouse models support the notion that a decrease in GH action is beneficial for maintenance of CNS integrity and functions as learning and memory during aging (263)(264)(265). Both in humans and rodents, circulating GH and IGF-1 levels decline with age, including in the central nervous system (CNS) (266).…”

Section: Roles In the Brainmentioning

confidence: 99%

Growth Hormone Receptor Regulation in Cancer and Chronic Diseases

et al. 2020

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“…Another study showed that GH deficiency could extend life span. Therefore, the role of GH in aging and cognition is yet to be established (Colon et al., 2019).…”

Section: Cellular and Molecular Mechanism Of Agingmentioning

confidence: 99%

Evaluation of the anti‐aging and antioxidant action of Ananas sativa and Moringa oleifera in a fruit fly model organism

Ajagun-Ogunleye

Ebuehi

2020

J. Food Biochem.

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aging is an inevitable biological complex process. It involves the gradual loss of cellular vitality due to accumulative damage to cellular macromolecules by reactive oxygen species (ROS). These ROS are highly implicated in health, disease, and lifespan. The biochemical pathways involved in the aging process are highly influenced by both exogenous (environmental factors) and endogenous stress factors. These cellular processes are the same in most organisms including the fruit fly, nematode, yeast, mammalian cell line, and rodents. These model organisms have been extensively used in the screening of potent antioxidant botanicals for anti-aging bioactivity. Moringa oleifera and Ananas sativa are great sources of health-promoting nutrients and antioxidants, however, their anti-aging impact is still an evolving area of research interest. Therefore, this review focused on their anti-aging mode of action and some other anti-aging nutriceuticals in different model organisms including the fruit fly. Practical applications Staying forever young and healthy is everyone's right. Aside from genetic trait, healthy feeding is peculiar to the world's longest-living people. Ananas sativa (pineapple) and Moringa oleifera leaves are highly valued fruit and herb with nourishing, antioxidant, and medicinal properties. Their extract exhibit antioxidant, anticancer, anti-inflammatory, and anti-aging activities. The ancient Greeks, Egyptians, and Romans used Moringa seed oil for cosmetics and perfumes. Moringa tea leaves is consumed for its nutritive and medicinal value. Its antioxidant potency endorses its use for anti-aging and other health-promoting purposes. The bioactive compound in pineapple, bromelain, promotes wound healing and it is a component of postsurgical applications due to its anti-inflammatory property. Consumption of Ananas fruit provides the recommended daily allowance of vitamin C, a potent antioxidant. To identify new antiaging bioactive compounds of therapeutic importance, and understanding the mode of action of these nutriceuticals will contribute to new anti-aging research prospects.

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The enigmatic role of growth hormone in age-related diseases, cognition, and longevity

Cited by 33 publications

References 121 publications

Effects of GH/IGF on the Aging Mitochondria

Effects of GH/IGF on the Aging Mitochondria

Growth Hormone Receptor Regulation in Cancer and Chronic Diseases

Evaluation of the anti‐aging and antioxidant action of Ananas sativa and Moringa oleifera in a fruit fly model organism

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