The enteric nervous system—an overview

Jabbur, Suhayl J.; El-Kak, Faysal; Nassar, Camille F.

doi:10.1002/med.2610080306

Cited by 11 publications

(5 citation statements)

References 57 publications

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“…ACh and NO are the main neurotransmitters of the ENS, mediating contraction [ 51 ] and relaxation [ 52 , 53 ], respectively. Surprisingly, experiments with atropine revealed that activation of muscarinic receptors counteracted Ang II-mediated contraction in the PC and MC of control rats and in the PC and DC of TNBS-induced rats ( Figure 7 B), which is in contrast with previously reported data [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Interaction between the Renin–Angiotensin System and Enteric Neurotransmission Contributes to Colonic Dysmotility in the TNBS-Induced Model of Colitis

Ferreira‐Duarte

Rodrigues-Pinto

Sousa

et al. 2021

IJMS

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Angiotensin II (Ang II) regulates colon contraction, acting not only directly on smooth muscle but also indirectly, interfering with myenteric neuromodulation mediated by the activation of AT1 /AT2 receptors. In this article, we aimed to explore which mediators and cells were involved in Ang II-mediated colonic contraction in the TNBS-induced rat model of colitis. The contractile responses to Ang II were evaluated in distinct regions of the colon of control animals or animals with colitis in the absence and presence of different antagonists/inhibitors. Endogenous levels of Ang II in the colon were assessed by ELISA and the number of AT1/AT2 receptors by qPCR. Ang II caused AT1 receptor-mediated colonic contraction that was markedly decreased along the colons of TNBS-induced rats, consistent with reduced AT1 mRNA expression. However, the effect mediated by Ang II is much more intricate, involving (in addition to smooth muscle cells and nerve terminals) ICC and EGC, which communicate by releasing ACh and NO in a complex mechanism that changes colitis, unveiling new therapeutic targets.

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Section: Discussionmentioning

confidence: 99%

Interaction between the Renin–Angiotensin System and Enteric Neurotransmission Contributes to Colonic Dysmotility in the TNBS-Induced Model of Colitis

Ferreira‐Duarte

Rodrigues-Pinto

Sousa

et al. 2021

IJMS

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“…The enteric nervous system lies within the intestinal wall, uninterrupted from the esophagous to the internal anal sphincter. Composed of neurons, glia, and occasional fibroblasts, the enteric nervous system is involved in the regulation of intestinal smooth muscle contractility, absorptive-secretory epithelium, and blood flow (Jabbur et at., 1988). Enteric glia, which outnumber enteric neurons 2:1, display morphological and molecular similarities to CNS astrocytes: They have irregular shapes, do not synthesize a basal lamina, and have an abundance of glial fibrillary acidic protein (GFAP) (Gershon and Rothman, 1991).…”

mentioning

confidence: 99%

Enteric Glia Exhibit P_2U Receptors that Increase Cytosolic Calcium by a Phospholipase C‐Dependent Mechanism

Kimball

Mulholland

1996

Journal of Neurochemistry

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Calcium signaling in fura-2 acetoxymethyl ester-loaded enteric glia was investigated in response to neuroligands; responses to AlP were studied in detail. Carbachol (1 mM), glutamate (100 jiM), norepinephrine (10 jiM), and substance P (1 pM) did not increase the intracellular calcium concentration ([Ca 24 ],) in cultured enteric glia. An increasing percentage of glia responded to serotonin (4%; 100 pM), bradykinin (11%; 10 1eM),

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“…The ENS is considered as an independent nerve system being able to programme and coordinate the GIT functions independently of directive impulses from the CNS (Costa et al 1987;Jabbur et al 1988).…”

Section: Discussionmentioning

confidence: 99%

A Fluorescent Microscopic Study of Adrenergic Innervation of the Appendix in Rabbits and Cats

Kočišová¹,

Schmidtová²,

Kuchta³

et al. 2000

Acta Vet. Brno

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The authors studied the innervation of the appendix in rabbits and cats. Adrenergic nerve components in rabbits were visualized by glyoxylic acid histofluorescence method and in cats by the method of formol-induced fluorescence of catecholamines and 5-HT.Adrenergic nerve components enter the appendix in the investigated species "from outside" in a common bundle with arteries and line these vessels in the form of plexiform bundles of nerve profiles as far as their terminal ramification in the organ wall. Nerve fibres, supplying both the longitudinal and circular layer of the wall musculature, branch away from the periarterial plexuses as well as nerve profiles entering the neuropil between neurocytes of myenteric and submucous plexuses. Moreover, they form loose plexuses of nerve fibres in the lamina muscularis mucosae and penetrate the mucosal glands. In the interdomal regions they finally branch out to loose and irregular plexuses of very delicate nerve profiles.In both species, the highest density of specifically fluorescent neural components is recorded in the compartmens of submucosa and mucosa, lying out of aggregated lymphoid follicles, whereas these fibres do not penetrate into the follicles, or B-dependent parts.

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The enteric nervous system—an overview

Cited by 11 publications

References 57 publications

Interaction between the Renin–Angiotensin System and Enteric Neurotransmission Contributes to Colonic Dysmotility in the TNBS-Induced Model of Colitis

Interaction between the Renin–Angiotensin System and Enteric Neurotransmission Contributes to Colonic Dysmotility in the TNBS-Induced Model of Colitis

Enteric Glia Exhibit P_2U Receptors that Increase Cytosolic Calcium by a Phospholipase C‐Dependent Mechanism

A Fluorescent Microscopic Study of Adrenergic Innervation of the Appendix in Rabbits and Cats

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The enteric nervous system—an overview

Cited by 11 publications

References 57 publications

Interaction between the Renin–Angiotensin System and Enteric Neurotransmission Contributes to Colonic Dysmotility in the TNBS-Induced Model of Colitis

Interaction between the Renin–Angiotensin System and Enteric Neurotransmission Contributes to Colonic Dysmotility in the TNBS-Induced Model of Colitis

Enteric Glia Exhibit P2U Receptors that Increase Cytosolic Calcium by a Phospholipase C‐Dependent Mechanism

A Fluorescent Microscopic Study of Adrenergic Innervation of the Appendix in Rabbits and Cats

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Enteric Glia Exhibit P_2U Receptors that Increase Cytosolic Calcium by a Phospholipase C‐Dependent Mechanism