The Enzymatic Hydrolysis of Polyphosphates in Tumor Tissue Its Influence on the in vivo Uptake

Abstract

The in vitro hydrolysis of polyphosphates by tissues from tumor-bearing animals has been studied. The analysis of the hydrolytic products indicates that the molecular break down occurs at the level of the terminal phosphate groups. The Mg++-dependent pyrophosphatase activity of tumor appears considerably diminished. Besides the fact that there is a relationship between hydrolysis and in vivo uptake with the phosphatase activity of the tissue, it seems possible that other mechanisms (as calcium-polyphosphate interaction) are involved in this uptake.