The epidemiologic and economic impact of a quadrivalent human papillomavirus vaccine in Thailand

Termrungruanglert, Wichai; Khemapech, Nipon; Vasuratna, Apichai; Havanond, Piyalamporn; Deebukkham, Preyanuch; Kulkarni, Amit; Pavelyev, A.

doi:10.1371/journal.pone.0245894

Cited by 12 publications

(13 citation statements)

References 17 publications

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“…For Thailand, despite the coverage of both the screening and vaccination programs was beyond 60%, the incidence of cervical cancer was still high with crude incidence rate of 25.6 per 100 000 women 28 . One possibility was that the national immunization program was only introduced in 2017, 29 and the benefit of the vaccines was not yet manifested by the current data.…”

Section: Discussionmentioning

confidence: 99%

A questionnaire study on disparity of cervical cancer prevention programs in Asia‐Oceania

Tse

Ushijima

Tan³

et al. 2023

J of Obstet and Gynaecol

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Background Despite the introduction of cervical cancer screening and human papillomavirus (HPV) vaccines, the utilization pattern was not standardized. The aim of this study was to elicit the current prevention care in Asia‐Oceania. Methods An online questionnaire was circulated to different countries/cities in Asia‐Oceania. The primary objective was to evaluate the coverage of HPV vaccination and cervical screening programs. The secondary objectives were to study the structures of these programs. Five case scenarios were set to understand how the respondents manage the abnormal screening results. Results Fourteen respondents from 10 countries/cities had participated. Cervical cancer ranked the first in Myanmar and Nepal. About 10%–15% did not have national vaccination or screening program. The estimated coverage rate for vaccination and screening varied from less than 1% to 70%, which the coverage ran in parallel with the incidence and mortality rates of cervical cancer. All regions approved HPV vaccines, although only four provided free or subsidized programs for nonavalent vaccine. Cervical cytology remained the most common screening tool, and 20%–30% relied heavily on visual inspection using acetic acid. The screening age groups varied in different regions. From the case scenarios, it was noted that some respondents tended to offer more frequent screening tests or colposcopy than recommended by international guidelines. Conclusion This study revealed discrepancy in the practice of cervical cancer prevention in Asia‐Oceania especially access to HPV vaccines. There is an urgent need for a global collaboration to eliminate cervical cancer by public education, reforming services, and medical training.

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Section: Discussionmentioning

confidence: 99%

A questionnaire study on disparity of cervical cancer prevention programs in Asia‐Oceania

Tse

Ushijima

Tan³

et al. 2023

J of Obstet and Gynaecol

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“…The prevalence of nonavalent vaccine-type HPV infection was approximately two times higher than that of the bivalent vaccine-type for both school grades. A study that assessed the impact of quadrivalent HPV vaccine use in Thailand showed it to be cost-effective with or without catch-up immunization [30] . Our findings demonstrated a substantial burden of HR HPV infection that is not targeted by bivalent or quadrivalent HPV vaccines.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of HPV infection among Thai schoolgirls in the north-eastern provinces in 2018: implications for HPV immunization policy

Vongpunsawad¹,

Rhee²,

Nilyanimit³

et al. 2023

IJID Regions

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“…In a study conducted in Thailand it was shown that if a catch-up program was implemented to vaccinate young women who were not previously vaccinated, it would cost less than 10,000 Thai Baht per Quality-of-Life Points (QUALYs). The recommended threshold for Thailand according to its government stood at 160,000 Thai Baht per QUALY proving that the implementation of a vaccination program would be cost effective ( 37 ). Therefore, it is important to consider the ultimate benefits of developing vaccination programmes for the health outcomes of the general population and the cost-effectiveness of such programmes.…”

Section: Vaccinationsmentioning

confidence: 99%

Cervical cancer, geographical inequalities, prevention and barriers in resource depleted countries (Review)

2022

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Cervical cancer (CC) remains a current global issue, with >90% of cervical cancer cases being attributed to human papilloma virus (HPV). The highest burden of cervical cancer is reported in resource-depleted geographical areas with a high incidence of HPV infection. Recent developments in primary prevention include vaccinations against specific strains of HPV and the psychoeducation of the public. Yet, despite the availability of vaccinations, there is high incidence of both HPV and cervical cancer in developing countries, which is attributed to a multitude of barriers including inaccessibility to expensive vaccines. With regards to secondary prevention, progress is actively being made to develop more effective methods of screening and to specifically address the needs of low-income countries. In the past few years, more novel screening methods, such as self-assessment kits, immunohistochemistry and methylation marker analysis, have been developed. Barriers to screening in resource-depleted countries include limited financial resources and infrastructure to develop screening programmes, a lack of screening programmes that are accessible to populations, inadequate training of healthcare teams and stigma related to medical examinations performed as part of screening. Developing primary and secondary prevention programs, as well as addressing the barriers involved in countries with low socioeconomic levels, can drastically reduce morbidity and mortality rates associated with cervical cancer, thus reducing the burden associated with this gynaecological malignancy. Contents1. Introduction 2. Epidemiology and geographical inequalities in the burden of CC 3. Primary prevention and barriers faced by developing countries 4. Vaccinations 5. Psychoeducation 6. Secondary prevention and challenges faced by developing countries 7. Recent developments in screening methods 8. Barriers to screening in low resource countries and strategies for improvement 9. Conclusion

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The epidemiologic and economic impact of a quadrivalent human papillomavirus vaccine in Thailand

Cited by 12 publications

References 17 publications

A questionnaire study on disparity of cervical cancer prevention programs in Asia‐Oceania

A questionnaire study on disparity of cervical cancer prevention programs in Asia‐Oceania

Prevalence of HPV infection among Thai schoolgirls in the north-eastern provinces in 2018: implications for HPV immunization policy

Cervical cancer, geographical inequalities, prevention and barriers in resource depleted countries (Review)

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