The epidemiology and antigenic characterization of influenza viruses isolated in Curitiba, South Brazil

Vidal, Luíne Rosele Renaud; Siqueira, Marilda Mendonça; Nogueira, Meri Bordignon; Raboni, Sonia M; Pereira, Luciane Aparecida; Takahashi, Gislene R.A.; Rotta, Indianara; Debur, Maria do Carmo; Dalla-Costa, Líbera Maria

doi:10.1590/s0074-02762008000200009

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…We detected influenza in 19.1% of the samples from the two groups of patients, which is in agreement with other Brazilian studies that have reported influenza A and B viruses as important causes of respiratory viral disease in immunocompromised and pediatric patients (9,10). The incidence of influenza infection among HSCT recipients is variable and is related to influenza epidemics in addition to the prevention measures adopted by each center.…”

Section: Discussionsupporting

confidence: 92%

Comparison of the direct fluorescence assay and real-time polymerase chain reaction for the detection of influenza virus A and B in immunocompromised patients

Perosa¹,

Watanabe²,

Guatura³

et al. 2013

Clinics

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OBJECTIVE:This study evaluated the diagnostic performance of two methods for the detection of influenza virus in immunocompromised transplant patients.METHODS:A total of 475 respiratory samples, 236 from patients in a hematopoietic stem cell transplantation program and 239 from kidney transplant patients, were analyzed by a direct fluorescence assay and the Centers for Disease Control real-time polymerase chain reaction protocol for influenza A and B detection.RESULTS:Influenza detection using either method was 7.6% in the hematopoietic stem cell transplant group and 30.5% in the kidney transplant patient group. Influenza detection by real-time polymerase chain reaction yielded a higher positive rate compared with fluorescence than that reported by other studies, and this difference was more pronounced for influenza A. The fluorescence assay sensitivity, specificity, positive and negative predictive values, and kappa coefficient were 17.6%, 100%, 1, 0.83, and 0.256, respectively, and lower detection rates occurred in the kidney transplant patients.CONCLUSIONS:The real-time polymerase chain reaction performance and the associated turnaround time for a large number of samples support the choice of this method for use in different routine diagnostic settings and influenza surveillance in high-risk patients.

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Section: Discussionsupporting

confidence: 92%

Comparison of the direct fluorescence assay and real-time polymerase chain reaction for the detection of influenza virus A and B in immunocompromised patients

Perosa¹,

Watanabe²,

Guatura³

et al. 2013

Clinics

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“…The death and hospitalisation rates varied in all countries (WHO 2009a). Morbidity and mortality resulting from seasonal influenza and other respiratory viruses have long been described in the country (Straliotto et al 2002, Bellei et al 2007, Vidal et al 2008). …”

Section: Discussionmentioning

confidence: 99%

Epidemiological aspects of influenza A related to climatic conditions during and after a pandemic period in the city of Salvador, northeastern Brazil

Silva

Siqueira

Netto

et al. 2014

Mem. Inst. Oswaldo Cruz

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During the influenza pandemic of 2009, the A(H1N1)pdm09, A/H3N2 seasonal and influenza B viruses were observed to be co-circulating with other respiratory viruses. To observe the epidemiological pattern of the influenza virus between May 2009-August 2011, 467 nasopharyngeal aspirates were collected from children less than five years of age in the city of Salvador. In addition, data on weather conditions were obtained. Indirect immunofluorescence, real-time transcription reverse polymerase chain reaction (RT-PCR), and sequencing assays were performed for influenza virus detection. Of all 467 samples, 34 (7%) specimens were positive for influenza A and of these, viral characterisation identified Flu A/H3N2 in 25/34 (74%) and A(H1N1)pdm09 in 9/34 (26%). Influenza B accounted for a small proportion (0.8%) and the other respiratory viruses for 27.2% (127/467). No deaths were registered and no pattern of seasonality or expected climatic conditions could be established. These observations are important for predicting the evolution of epidemics and in implementing future anti-pandemic measures.

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“…In all, 12 articles presenting evidence on influenza B virus circulation in Brazil for the years 1996-2013 were included. [30][31][32][33][34][35][36][37][38][39][40][41] Details for each of the studies are shown in Supplementary File 1.…”

Section: Online Literature Searchmentioning

confidence: 99%

Patterns of influenza B circulation in Brazil and its relevance to seasonal vaccine composition

Barros

Cintra

Rossetto³

et al. 2016

The Brazilian Journal of Infectious Diseases

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Data on the burden of disease and circulation patterns of influenza B lineages for Brazil are limited. This review aims to describe the pattern of influenza B occurrence in Brazil to have a better understanding of its epidemiology and its relevance when considering seasonal influenza vaccine composition. A review of the data including analysis of international and local surveillance data as well as information from online search of databases using Medical Subject Headings terms in conjunction with screening of abstracts from scientific events was performed. Based on international epidemiologic surveillance data, moderate levels of influenza B disease (19%; 2006-2014) were observed. Of these nine years, it was possible to compare data from three years (2007, 2008 and 2013) which have information on the circulating influenza B lineage. Co-circulation of influenza B lineages was observed in all these three influenza seasons, of which, during one season, a high degree of mismatch between the vaccine lineage and the predominant circulating lineage (91.4% [2013]) was observed. Local surveillance data reveal a distinct and dynamic distribution of respiratory viruses over the years. Data from published literature and abstracts show that influenza B is a significant cause of disease with an unpredictable circulation pattern and showing trends indicating reemergence of the B/Victoria lineage. The abstracts report notable levels of co-circulation of both influenza B lineages (2000-2013). Mismatch between the Southern hemisphere vaccine and the most prevalent circulating viruses in Brazil were observed in five influenza seasons. The evidence on co-circulation of two influenza B lineages and mismatched seasons in Brazil indicates the benefit of quadrivalent influenza vaccines in conferring broader seasonal influenza protection. Additionally, improving influenza surveillance platforms in Brazil is important for monitoring disease trends and the impact of introducing seasonal influenza vaccination.

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The epidemiology and antigenic characterization of influenza viruses isolated in Curitiba, South Brazil

Cited by 9 publications

References 25 publications

Comparison of the direct fluorescence assay and real-time polymerase chain reaction for the detection of influenza virus A and B in immunocompromised patients

Comparison of the direct fluorescence assay and real-time polymerase chain reaction for the detection of influenza virus A and B in immunocompromised patients

Epidemiological aspects of influenza A related to climatic conditions during and after a pandemic period in the city of Salvador, northeastern Brazil

Patterns of influenza B circulation in Brazil and its relevance to seasonal vaccine composition

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