The epidemiology of adolescent acne in North East China

Wei, Bin; Pang, Yu; Zhu, Hong; Qu, Lei; Xiao, Ting; Wei, Huachen; Chen, H. D.; He, Chundi

doi:10.1111/j.1468-3083.2010.03590.x

Cited by 83 publications

(95 citation statements)

References 16 publications

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“…Our study is compatible with another study that showed undergraduate students to have acne by 78% heritability in first-degree relative's [18]. Previous studies showed that moderate to severe acne were strongly associated with firstdegree relative's acne history [5] [19].…”

Section: Discussionsupporting

confidence: 82%

Acne Vulgaris in Jeddah Medical Students: Prevalence, Severity, Self-Report, and Treatment Practices

Zari¹,

Turkistani²

2017

JCDSA

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Acne is a common skin disorder of teenagers and continues into adulthood. Research has been limited regarding acne prevalence, perception and health care utilization in Saudi Arabia. The objective of this study was to assess acne prevalence in final year female medical students in Jeddah, Saudi Arabia using the global acne grading system (GAGS) compared with student's self-report of their acne. This is a cross-sectional study conducted among 151 students during 2016, in which students were interviewed subjectively and examined objectively by a trained physician. This study showed that acne was reported subjectively by 83.4% of female students compared to 98% of students assessed objectively by the global acne grading system. 14.6% of students claimed having no acne while it was objectively present, which was statistically significant (Χ 2 = 15.4, P < 0.001). 41% visited a dermatologist and 28.5% waited 1 year until seeking a dermatologist. However, 35.8% of students got an overthe-counter drug for their acne. Surprisingly, treatment duration expectation was <1 week in 9.9% compared to >2 months in 39.1% of students. Acne was present in 41.1% of the students parents compared to 83.4% in their siblings. A total of 41.7% of student had trunk acne. 60.9% of students had scarring and 72.8% of them had pigmentation. Moderate to severe acne students had higher siblings acne history of 95.2% (Χ 2 = 5.85, P < 0.05), higher scaring of 73.8% (Χ 2 = 4.05, P < 0.05), and higher pigmentation of 85.7% (Χ 2 = 4.87, P < 0.05) which was statistically significant. Our study confirms that acne is very common in female medical students in Jeddah, Saudi Arabia with a prevalence rate of 98%. Knowledge regarding acne treatment was inadequate demonstrating the need for educational and awareness programs about early treatment that will prevent suffering from acne scarring or pigmentation.

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Section: Discussionsupporting

confidence: 82%

Acne Vulgaris in Jeddah Medical Students: Prevalence, Severity, Self-Report, and Treatment Practices

Zari¹,

Turkistani²

2017

JCDSA

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“…This observation is in accordance to studies of Tallab and Adityan et al 7,9 Although acne is not an inherited condition, there is an inherited predisposition. 18,19 We observed family history of acne in 52.5% of our patients; 62.5% patients of grade 4 acne vulgaris had a positive family history of acne. Cunliffe and Gollnick reported family history in 40% and Kubota et al in 56.8% of their patients of acne vulgaris.…”

Section: Discussionmentioning

confidence: 48%

Clinical profile of acne vulgaris in semiurban patients

Saxena¹,

Shah²,

Singh

et al. 2018

Int J Res Dermatol

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Background: Acne is a chronic inflammatory disease of the pilosebaceous unit, mainly affecting face and frequently followed by scarring. It is the most common skin disease in an urban dermatology clinic in India. Adult acne is more common in women and may be a marker of hyperandrogenism.The present study was carried out to study the clinical profile of acne vulgaris in semiurban patients.Methods: The study was conducted for 1 year on all eligible patients of acne vulgaris attending dermatology OPD of a hospital catering to semiurban patients. Data including grade of acne, markers of androgenicity and post-acne scarring was collected. Statistical analysis was done using SPSS 15 software.Results: Frequency of acne vulgaris patients in the dermatology OPD was 2.8% with 429 acne patients out of 15,322 new patients. Female to male ratio was 1.44:1. The mean age of onset in males was 16.24 and in females, 14.84 years. Grade 2 acne (66%) was commonest followed by grade 3 (5.1%) and grade 4 (3.7%). Associated conditions seen were seborrhea (60.8%), alopecia (18.9%), acanthosis (4.9%) and PCOD (2.3%). Markers of androgenicity were more frequently seen in grade 2 acne which was statistically significant. Atrophic scars were commonest including icepick scars (80.2%), rolling scars (67.4%) and box scars (57.8%). Conclusions: In our study females had an earlier onset and closed comedones were the most common acne lesion. Grade 2 acne vulgaris formed majority of patients. Grade 4 acne vulgaris was more common in males.

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“…In a study of 1,002 16-year-olds of Iranian descent, a positive family history of acne was shown to double the risk of suffering from severe acne [6]. Furthermore, a large study of Chinese undergraduates showed that among Han Chinese students, the heritability of acne was 78% for individuals who had first-degree relatives with acne [7]. Despite these implications of a genetic association, to date only a handful of genes have been investigated as potential predisposing or susceptibility factors for acne [8], and the underlying genetic basis of acne remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Genotype-Phenotype Correlations in Severe Acne in a Han Chinese Population

Yang

Wu²,

He³

et al. 2014

Dermatology

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Background: Two novel susceptibility gene loci (1q24.2 and 11p11.2) for severe acne have been identified in a genome-wide association study of a Han Chinese population. Objective: The current study investigated the relationships of these gene loci with clinical phenotypes, including onset age, atrophic scarring, hypertrophic scarring and family history. Furthermore, we investigated the correlations between these four clinical phenotypes. Methods: We used the χ² test to compare the allele frequency among the different clinical phenotypes. We calculated Spearman's correlation coefficient to measure the relationship between the different clinical phenotypes. Results: We identified significant associations between the 11p11.2 locus and disease family history (p < 0.05). We also determined that hypertrophic scarring was moderately correlated with atrophic scarring (r_s = 0.315). Conclusions: This study suggests that the susceptibility gene locus 11p11.2 may contribute to the complex phenotypes of severe acne, particularly in cases of hereditary severe acne, whereas there are also correlations between the different phenotypes.

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The epidemiology of adolescent acne in North East China

Abstract: Adolescent acne includes a familial genetic predisposition. Additional environmental factors of psychological stress, skin oiliness and high caloric diets may also contribute to the onset of acne in Chinese adolescents.

Cited by 83 publications

References 16 publications

Acne Vulgaris in Jeddah Medical Students: Prevalence, Severity, Self-Report, and Treatment Practices

Acne Vulgaris in Jeddah Medical Students: Prevalence, Severity, Self-Report, and Treatment Practices

Clinical profile of acne vulgaris in semiurban patients

Genotype-Phenotype Correlations in Severe Acne in a Han Chinese Population

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