The epidemiology of benign prostatic hyperplasia: a study in Greece

Signorello,; Tzonou,; Lagiou,; Samoli,; Zavitsanos,; Trichopoulos,

doi:10.1046/j.1464-410x.1999.00199.x

Cited by 42 publications

(30 citation statements)

References 29 publications

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“…27,29,31,[33][34][35][36][37][38][39][40][42][43][44][45] When BPH and LUTS were combined, we observed that the BMI was associated with BPH or LUTS (Figure 1, OR ¼ 1.23, 95% CI 1.03-1.48) and the summary OR were similar in population-based casecontrol study, whereas the summary OR in cohort study and hospital-based case-control study showed no association between BMI and BPH/LUTS. Heterogeneity was detected (Po0.05) among all studies and in the subgroup of population-based case-control studies.…”

Section: Bph and Luts Combinedmentioning

confidence: 70%

Body mass index and risk of BPH: a meta-analysis

Wang

Mao

Lin

et al. 2011

Prostate Cancer Prostatic Dis

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BACKGROUND: Epidemiological studies have reported conflicting results relating obesity to BPH. A meta-analysis of cohort and case-control studies was conducted to pool the risk estimates of the association between obesity and BPH.METHODS: Eligible studies were retrieved by both computer searches and review of references. We analyzed abstracted data with random effects models to obtain the summary risk estimates. Dose-response meta-analysis was performed for studies reporting categorical risk estimates for a series of exposure levels. RESULTS:A total of 19 studies met the inclusion criteria of the meta-analysis. Positive association with body mass index (BMI) was observed in BPH and lower urinary tract symptoms (LUTS) combined group (odds ratio ¼ 1.27, 95% confidence intervals 1.05-1.53). In subgroup analysis, BMI exhibited a positive dose-response relationship with BPH/LUTS in population-based case-control studies and a marginal positive association was observed between risk of BPH and increased BMI. However, no association between BPH/LUTS and BMI was observed in other subgroups stratified by study design, geographical region or primary outcome. CONCLUSIONS:The overall current literatures suggested that BMI was associated with increased risk of BPH. Further efforts should be made to confirm these findings and clarify the underlying biological mechanisms.

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Section: Bph and Luts Combinedmentioning

confidence: 70%

Body mass index and risk of BPH: a meta-analysis

Wang

Mao

Lin

et al. 2011

Prostate Cancer Prostatic Dis

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“…No association was found for diabetes, history of hypertension and hyperlipidemia, in agreement with most epidemiological evidence. 2,3,5,7,10 A potential weakness of this study is the lack of a precise definition of BPH, as there is no unique clinical definition of this disease. 1 Although we excluded from the control group all subjects who reported a diagnosis of BPH or prostate cancer, a potential source of bias could derive from undetected cases of BPH in the control group.…”

Section: Discussionmentioning

confidence: 99%

“…1 Among prospective studies considering the relation between body weight and BPH risk, the prospective Veterans Administration Normative Aging Study found a direct association; 2 the Northern California Kaiser Permanente Medical Care Program found an inverse association; 3 a cohort of 929 men from California; 4 and the population-based Massachussetts Male Aging Study cohort 5 found no association; 4,5 and the Health Professionals Follow-up Study found a direct association with abdominal obesity, but not with body mass index (BMI, kg/m 2 ). 6 Among case-control studies, a Greek one found no association between BMI and BPH, 7 and a Chinese one found no relation with BMI, but a direct association with waist-to-hip ratio. 8 Two other studies found direct associations.…”

Section: Introductionmentioning

confidence: 99%

History of weight and obesity through life and risk of benign prostatic hyperplasia

et al. 2005

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OBJECTIVE:The relation of anthropometric measures, diabetes, hypertension and hyperlipidemia with benign prostatic hyperplasia (BPH) risk was investigated. DESIGN: Hospital-based case-control study. SUBJECTS: Cases were 1369 men with histologically confirmed BPH, and controls were 1451 men below 75 y, admitted to hospital for acute non-neoplastic diseases. MEASUREMENTS: Using a structured questionnaire, trained interviewers collected information on self-reported height and weight, and measured waist and hip circumference of patients. The odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional multiple logistic regression models. RESULTS: Compared to the corresponding lowest quartile, the OR for the highest one were 0.76 (95% CI 0.59-0.98) for body weight, 0.71 (95% CI 0.54-0.94) for waist-to-hip ratio and 0.87 (95% CI 0.70-1.09) for body mass index (BMI, kg/m 2 ). Compared to a lowest lifelong BMI o20.7 kg/m 2 , the OR was 1.56 (95% CI 1.25-1.95) for a lowest lifelong BMI Z23.7 kg/m 2 . The OR was 0.74 (95% CI 0.60-0.93) for a lifelong increase of BMI Z6.1 kg/m 2 , compared to o1.6 kg/m 2 . No association emerged for history of diabetes, hypertension and hyperlipidemia. CONCLUSIONS: Overweight was modestly, inversely related to BPH. The hypothesis of reduced testosterone levels in obese individuals may explain the different BPH risk and need to be tested.

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“…1 Although a growing epidemiological evidence suggests that genetic characteristics and lifestyle factors related to levels of androgens and estrogens are associated to BPH, 2 relatively few epidemiological studies have been conducted on potentially modifiable risk factors such as diet, alcohol consumption, and obesity. [2][3][4][5][6][7] In particular, the relation between physical activity (PA) and BPH risk has been investigated in few epidemiological studies. One case-control study was conducted in a low-risk population (China), including 206 BPH cases, 8 to assess energy expenditure for occupational and recreational PA at different ages.…”

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confidence: 99%

Lifetime occupational and recreational physical activity and risk of benign prostatic hyperplasia

Maso

Zucchetto

Tavani

et al. 2006

Intl Journal of Cancer

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To investigate the relation between occupational and recreational physical activity (PA) in different periods of life and the risk of benign prostatic hyperplasia (BPH), we conducted a hospital-based, case-control study in Italy. The study included 1,369 histologically confirmed BPH and 1,451 controls, admitted to the same hospitals for acute, nonneoplastic diseases. Odds ratios (ORs) and 95% confidence intervals (CIs) of BPH, according to lifetime PA, were obtained by unconditional multiple logistic regression models, including terms for age, study center and education. Compared to the lowest level of occupational PA, the multivariate ORs for BPH for the heavy/strenuous level were 0.6 (95% CI, 0.4-0.8) at age 15-19, 0.6 (95% CI, 0.4-0.8) at age 30-39 and 0.7 (95% CI, 0.5-0.9) at age 50-59. Moreover, compared to <2 hr/week of recreational PA, the ORs for BPH for the highest level ( 5 hr/week) were 0.5 (95% CI, 0.4-0.7) at age 15-19, 0.6 (95% CI, 0.5-0.8) at age 30-39, and 0.7 (95% CI, 0.5-0.8) at age 50-59. All inverse trends in risk were significant, and no heterogeneity was found by reason of BPH-diagnosis, age at diagnosis, and body mass index (BMI). The inverse association between PA and BPH risk may be due to favorable hormonal correlates of PA, but residual confounding by socioeconomic covariates cannot be excluded. A moderate PA at any ages may help reducing a sizeable number of BPH. ' 2005 Wiley-Liss, Inc.Key words: physical activity; benign prostatic hyperplasia; casecontrol study Benign prostatic hyperplasia (BPH) is a condition relatively frequent in men aged 60 or above. BPH can cause prostate enlargement, lower urinary tract symptoms and serious medical complications (e.g. urinary obstruction, renal failure, etc.). 1 Although a growing epidemiological evidence suggests that genetic characteristics and lifestyle factors related to levels of androgens and estrogens are associated to BPH, 2 relatively few epidemiological studies have been conducted on potentially modifiable risk factors such as diet, alcohol consumption, and obesity. [2][3][4][5][6][7] In particular, the relation between physical activity (PA) and BPH risk has been investigated in few epidemiological studies. One case-control study was conducted in a low-risk population (China), including 206 BPH cases, 8 to assess energy expenditure for occupational and recreational PA at different ages. This study did not suggest an association between PA and BPH.Three cohort studies have also evaluated data on the topic. The Physicians' Health Study, based on 320 cases, 9 included only information on leisure-time exercise and showed inconsistent inverse associations between BPH and PA across strata of exercise. In the ''Massachusetts Male Aging'' prospective study (198 cases), 10 an inverse association emerged between BPH and total PA at enrollment (median 9 years before diagnosis). The Health Professional follow-up study, including 3,743 cases, 11 showed that risk of BPH decreased linearly with the increase of recreational PA, and that walking had...

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The epidemiology of benign prostatic hyperplasia: a study in Greece

Abstract: The lifestyle factors assessed here have no major effect on the aetiology of BPH.

Cited by 42 publications

References 29 publications

Body mass index and risk of BPH: a meta-analysis

Body mass index and risk of BPH: a meta-analysis

History of weight and obesity through life and risk of benign prostatic hyperplasia

Lifetime occupational and recreational physical activity and risk of benign prostatic hyperplasia

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