The epidemiology of bronchioloalveolar carcinoma over the past two decades: analysis of the SEER database

Read, William; Page, Nathan; Tierney, Ryan M.; Piccirillo, Jay F.; Govindan, Ramaswamy

doi:10.1016/j.lungcan.2004.01.019

Cited by 109 publications

(74 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Unlike Zell et al, 34 however, we were able to analyze a subgroup of patients who underwent surgery and had available hospital records with the ASA classifi cations that we could use as a surrogate veillance Epidemiology and End Results database study. 38 In our analytic cohort, 7.3% of never smokers had BACs, which, again, is similar to the 12.6% prevalence found in a large analysis of data from the Cancer Surveillance Programs of Orange County, Imperial County, and San Diego County, California. 34 Interestingly, studies that show overall survival benefi t of never smokers often have very high prevalence of this histologic subtype in populations of neversmokers of any one particular study.…”

Section: Discussionsupporting

confidence: 86%

Long-term Survival Outcomes by Smoking Status in Surgical and Nonsurgical Patients With Non-small Cell Lung Cancer

Meguid¹,

Hooker²,

Harris³

et al. 2010

Chest

View full text Add to dashboard Cite

Lung cancer is the leading cause of cancer death in the United States. 1 Although it is well known that lung cancer is associated with tobacco use, it is also apparent that never smokers are susceptible to the disease. Comparisons of genetic and epigenetic aberrations in non-small cell lung cancer (NSCLC) among smokers and never smokers have revealed marked differences in tumor biology that have resulted in clinicopathologic distinctions between smokers and never smokers. Data have established that mutational differences in the active kinase domain of the epidermal growth factor receptor confer increased sensitivities of a subset of never smokers with lung cancer to tyrosine kinase inhibitors. 2,3 Less well established is the actual natural history of NSCLC in never smokers compared with smokers. Emerging tumor biology data, especially recent reports highlighting fewer genomic alterations in never smokers, such as gene Results: Never smokers were signifi cantly more likely than current smokers to be women ( P , .01), older ( P , .01), and to have adenocarcinoma ( P , .01) and bronchioloalveolar carcinoma ( P , .01). No statistically signifi cant differences existed in stage distribution at presentation for the analytic cohort ( P 5 .35) or for the subgroup undergoing surgery ( P 5 .24). The strongest risk factors of mortality among patients with NSCLC who underwent surgery were advanced stage (adjusted hazard ratio, 3.43; 95% CI, 2.32-5.07; P , .01) and elevated American Society of Anesthesiologists classifi cation (adjusted hazard ratio, 2.18; 95% CI, 1.40-3.40; P , .01). The minor trend toward an elevated risk of death on univariate analysis for current vs never smokers in the surgically treated group (hazard ratio, 1.20; 95% CI, 0.98-1.46; P 5 .07) was completely eliminated when the model was adjusted for covariates ( P 5 .97). Conclusions: Our fi ndings suggest that smoking status at time of lung cancer diagnosis has little impact on the long-term survival of patients with NSCLC, especially after curative surgery. Despite different etiologies between lung cancer in never and current smokers the prognosis is equally dismal.CHEST 2010; 138(3):500-509Abbreviations: aHR 5 adjusted hazard ratio; AJCC 5 American Joint Commission on Cancer; ASA 5 American Society of Anesthesiologists; BAC 5 bronchioloalveolar carcinoma; HR 5 hazard ratio; NSCLC 5 non-small cell lung cancer

show abstract

Section: Discussionsupporting

confidence: 86%

Long-term Survival Outcomes by Smoking Status in Surgical and Nonsurgical Patients With Non-small Cell Lung Cancer

Meguid¹,

Hooker²,

Harris³

et al. 2010

Chest

View full text Add to dashboard Cite

show abstract

“…Although pure BACs are uncommon, adenocarcinomas with BAC features are common (Ebright et al, 2002). Adenocarcinomas with BAC features have been increasing in incidence in the past two decades (Read et al, 2004). For assessment of non-solid solitary pulmonary nodules, the cutoff of 1.5 was used for SUVmax (Tsushima et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Performance of Diffusion Weighted Imaging of Malignant and Benign Pulmonary Nodules and Masses: Comparison with Positron Emission Tomography

Usuda

Sagawa

Motono

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…Biologic features of adenocarcinomas in women, as represented by localized bronchioloalveolar carcinomas (BACs) showing low aggressiveness, may result in better prognoses. 12) Multiple previous studies [13][14][15] reported a survival advantage for women with resected NSCLC to be limited to patients with earlier disease stages or a nonsquamous histology. If this is so, the proportion of stage I and adenocarcinoma cases, and probably smoking status in the patients studied might affect comparisons of survival between genders.…”

Section: Female Gender Is An Independent Prognostic Factor In Non-smamentioning

confidence: 99%

Female Gender Is an Independent Prognostic Factor in Non-small-cell Lung Cancer: A Meta-analysis

Nakamura

Ando

Shinmyo

et al. 2011

Ann Thorac Cardiovasc Surg

120

View full text Add to dashboard Cite

Purpose: It is not clear whether women with non-small-cell lung cancer (NSCLC) live significantly longer than men. Thus, we conducted a meta-analysis of published studies to quantitatively compare NSCLC survival data between genders. Materials and Methods: A MEDLINE Web search for computer-archived bibliographic data regarding overall survival differences between genders was performed. DerSimonian-Laird random effects analysis was used to estimate the pooled hazard ratio (HR). Results: We selected 39 articles as appropriate data sources, involving 86 800 patients including 32 701 women and 54 099 men. Combined HRs for women vs. men in studies using univariate and multivariate analyses respectively were 0.79 (p <0.0001) and 0.78 (p <0.0001). Pooled HRs for 3 study subgroups having (1) fewer than 30% stage I cases, (2) fewer than 50% adenocarcinoma cases, and (3) statistical adjustment for smoking status all indicated the survival advantage of women. Conclusion: This meta-analysis of published data concerning NSCLC patients indicated significantly better survival for women.

show abstract

The epidemiology of bronchioloalveolar carcinoma over the past two decades: analysis of the SEER database

Cited by 109 publications

References 10 publications

Long-term Survival Outcomes by Smoking Status in Surgical and Nonsurgical Patients With Non-small Cell Lung Cancer

Long-term Survival Outcomes by Smoking Status in Surgical and Nonsurgical Patients With Non-small Cell Lung Cancer

Diagnostic Performance of Diffusion Weighted Imaging of Malignant and Benign Pulmonary Nodules and Masses: Comparison with Positron Emission Tomography

Female Gender Is an Independent Prognostic Factor in Non-small-cell Lung Cancer: A Meta-analysis

Contact Info

Product

Resources

About