The epidemiology of <i>Salmonella dublin</i> infection in a dairy herd: I. Excretion and persistence of the organism

Lawson, G.H.K.; McPherson, E. A.; Laing, A. H.; Wooding, P.

doi:10.1017/s0022172400023548

Cited by 11 publications

(6 citation statements)

References 8 publications

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“…As recorded previously S. dublin was isolated from the bile of U38 at slaughter (Lawson et al 1974) but not from other individuals of comparable age and similarly infected as neonates. Whilst this calf showed raised CFT(P) and CFT(A) titres persisting for 5 months it could not be differentiated serologically at the time of slaughter from the other members of the group.…”

Section: Adult Cattlesupporting

confidence: 55%

“…The details of the detection of infected cattle and the circumstances of the outbreak have been discussed in a previous paper (Lawson, McPherson, Laing & Wooding, 1974 (Alton & Jones, 1967), the density of the diluted antigen corresponding approximately to Brown's opacity tube 3. S. dublin antisera used for standardization were kept in small aliquots at -70 C.…”

Section: Introductionmentioning

confidence: 99%

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The epidemiology of Salmonella dublin infection in a dairy herd: II. Serology

Lawson¹,

McPherson²,

Wooding³

1974

J. Hyg.

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SUMMARYA number of serological tests were evaluated in a study of Salmonella dublin infection in a dairy herd. None of the tests used detected either of the two carrier animals from which Salmonella dublin was isolated at slaughter 7 and 17 months after the herd infection. The complement fixation tests used proved to be a better guide to the presence of recent herd infection than the conventional ‘0’ or ‘H’ agglutination tests.

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Section: Adult Cattlesupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

The epidemiology of Salmonella dublin infection in a dairy herd: II. Serology

Lawson¹,

McPherson²,

Wooding³

1974

J. Hyg.

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“…Sojka et al [ 78 ] reported moderately heavy excretion (Log 4–5 /g faeces) for 2.5 years with isolation at postmortem from the liver, spleen, hepatic lymph node and gall bladder (Log 4–7/gm). In cattle, Lawson et al, [ 109 ] reported one persistently shedding calf with an infected gall bladder until adulthood at one year of age.…”

Section: What Is/are the Main Site(s) Of Carriage And Dissemination?mentioning

confidence: 99%

Revisiting Persistent Salmonella Infection and the Carrier State: What Do We Know?

Foster¹,

Tang

Berchieri

et al. 2021

Pathogens

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One characteristic of the few Salmonella enterica serovars that produce typhoid-like infections is that disease-free persistent infection can occur for months or years in a small number of individuals post-convalescence. The bacteria continue to be shed intermittently which is a key component of the epidemiology of these infections. Persistent chronic infection occurs despite high levels of circulating specific IgG. We have reviewed the information on the basis for persistence in S. Typhi, S. Dublin, S. Gallinarum, S. Pullorum, S. Abortusovis and also S. Typhimurium in mice as a model of persistence. Persistence appears to occur in macrophages in the spleen and liver with shedding either from the gall bladder and gut or the reproductive tract. The involvement of host genetic background in defining persistence is clear from studies with the mouse but less so with human and poultry infections. There is increasing evidence that the organisms (i) modulate the host response away from the typical Th1-type response normally associated with immune clearance of an acute infection to Th2-type or an anti-inflammatory response, and that (ii) the bacteria modulate transformation of macrophage from M1 to M2 type. The bacterial factors involved in this are not yet fully understood. There are early indications that it might be possible to remodulate the response back towards a Th1 response by using cytokine therapy.

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“…Serological tests were of little value in these herds where infection is endemic, and few animals had titres indicative of infection. In herds where recent infection has occurred many animals have high levels of agglutinins to S. dublin (Lawson et al 1974;Wray, Morris & Sojka, 1975) and it is possible that the low titres observed reflect the decline in titre that occurs with time. Rectal swabs were also of debatable use and the best time to sample animals would appear to be at parturition when S. dublin may be excreted by a number of routes.…”

Section: Discussionmentioning

confidence: 99%

Salmonellosis in two dairy herds associated with a sewage farm and water reclamation plant

Clegg

Wray

Duncan

et al. 1986

J. Hyg.

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SUMMARYTwo dairy herds, situated on a sewage farm, were monitored for the presence of salmonellas following outbreaks of Salmonella dublin infection. In addition an S. dublin control scheme, which involved examination of adult animals and calf vaccination, was instigated.During the period 1975-84, 12 salmonella serotypes and 10 phage types of S. typhimurium were isolated from the cattle and their environment although their presence was seldom associated with disease. Two adult S. dublin excreters were detected but it was concluded that none of the tests employed to examine the adult animals was sensitive enough. The prevalence of disease in the calves was low and although vaccination may have been beneficial it did not eradicate S. dublin infection. Thus S. dublin persisted in adults and calves during the 8-year period but its presence was seldom associated with disease. The results are discussed with regards the disease risk to animals from the agricultural use of sewage sludge and the public health aspects.

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The epidemiology of Salmonella dublin infection in a dairy herd: I. Excretion and persistence of the organism

Cited by 11 publications

References 8 publications

The epidemiology of Salmonella dublin infection in a dairy herd: II. Serology

The epidemiology of Salmonella dublin infection in a dairy herd: II. Serology

Revisiting Persistent Salmonella Infection and the Carrier State: What Do We Know?

Salmonellosis in two dairy herds associated with a sewage farm and water reclamation plant

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