The epidermal response to subepidermal inflammation

Abstract

A marked degree of hyperproliferation and hyperplasia of the epidermis secondary to experimentally induced inflammation in the corium was induced in the flank skin of guinea pigs. The substances used to evoke a granulomatous inflammation were beryllium oxide and carrageenan. The epidermal response to this subepidermal process was studied autoradiographically and it was found that the epidermal reaction was similar to that found after direct epidermal trauma such as stripping of the horny layer. It is assumed that dermal factors are responsible for initiating this epidermal reaction and their possible nature is briefly discussed.

Transepidermal elimination in cutaneous leishmaniasis: a multiregional study

“…The association of epidermal pseudocarcinomatous hyperplasia with transepidermal elimination, when occurring as a secondary component of a primary skin disease, has been observed in the infectious disorders previously described 4,48,49 . A role for the dermal inflammatory response, caused by the infectious organism, in initiating the hyperplasia has also been highlighted in this setting; a finding consistent with earlier experimental results whereby irritants in the superficial dermis incited inflammation and epithelial proliferation 50 . In our study, pseudocarcinomatous hyperplasia was significantly higher in cases with transepidermal elimination; however, cases with a normal or atrophic epidermis were also noted.…”

“…4,48,49 A role for the dermal inflammatory response, caused by the infectious organism, in initiating the hyperplasia has also been highlighted in this setting; a finding consistent with earlier experimental results whereby irritants in the superficial dermis incited inflammation and epithelial proliferation. 50 In our study, pseudocarcinomatous hyperplasia was significantly higher in cases with transepidermal elimination; however, cases with a normal or atrophic epidermis were also noted. This suggests that, for the majority of cases, the previously described sequence of epidermal hyperplasia followed by engulfment of the foreign substance eventually leading to its extrusion is the predominant pattern.…”

Penetration of gold nanoparticles across the stratum corneum layer of thick-Skin

“…To assess any possible detrimental effect of AuNPs exposure on thick-skin, we measured the epidermal thickness, a common indicator of skin irritation and toxicity [17,18], in hematoxylin and eosin stained hind-paw skin sections harvested from rats, 4 days after AuNPs exposure (Fig. 6a-c).…”