The eradication experience of enzootic bovine leukosis from Lithuania

Acaite, Juzefa; Tamosiunas, Vytas; Lukauskas, Kazimieras; Milius, Jonas; Pieskus, J.

doi:10.1016/j.prevetmed.2007.05.010

Cited by 69 publications

(58 citation statements)

References 19 publications

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“…Discussion BLV infection is highly prevalent in dairy herds in many countries and leads to major economic losses in cattle production and exportation. Only a few countries have developed a successful policy to completely eradicate the virus from their herds [1,5,27]. Considering this fact, it is necessary to identify the molecular genetic markers of susceptibility or resistance to this infectious disease for effective breeding [31].…”

Section: Proviral Load Distributionmentioning

confidence: 99%

“…It is distributed all over the world and mainly infects domestic cattle, with major incidence within dairy herds due to management conditions [13]. Many efforts have been made to eradicate this virus from the herds, and some countries, mostly in the EU, have completely eradicated the infection [1,5,27]. Once the animal becomes infected with BLV, the provirus integrates into the host genome, and the host remains infected for life.…”

Section: Introductionmentioning

confidence: 99%

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Association of TNF-α gene promoter region polymorphisms in bovine leukemia virus (BLV)-infected cattle with different proviral loads

et al. 2015

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Tumor necrosis factor alpha (TNF-a) is a pleiotropic cytokine involved in the immune response against viral and other infections. Its expression levels are affected by a polymorphism in the promoter region of the gene. Bovine leukemia virus is a retrovirus that infects cattle and develops two different infection profiles in the host. One profile is characterized by a high number of proviral copies integrated into the host genome and a strong immune response against the virus, while the most relevant property of the other profile is that the number of copies integrated into the host genome is almost undetectable and the immune response is very weak. We selected a population of cattle sufficiently large for statistical analysis and classified them according to whether they had a high or low proviral load (HPL or LPL). Polymorphisms in the promoter region were identified by PCR-RFLP. The results indicated that, in the HPL group, the three possible genotypes were normally distributed and that, in the LPL group, there was a significant association between the proviral load and a low frequency of the G/G genotype at position -824.

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Section: Proviral Load Distributionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of TNF-α gene promoter region polymorphisms in bovine leukemia virus (BLV)-infected cattle with different proviral loads

et al. 2015

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“…BLV infection has a worldwide distribution, and EBL is listed by the World Organization for Animal Health as a disease that can have a significant impact on international trade [22]. In certain countries, EBL has been successfully eradicated through national control programs, such as those used in Europe [1,20].…”

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confidence: 99%

Nationwide Survey of Bovine Leukemia Virus Infection among Dairy and Beef Breeding Cattle in Japan from 2009–2011

et al. 2013

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ABSTRACT. A nationwide survey of bovine leukemia virus (BLV) infection was conducted among dairy and beef breeding cattle in Japan from 2009-2011 using an enzyme-linked immunosorbent assay. Of a total of 20,835 cattle tested, 35.2% were seropositive for BLV and the animal type-level seroprevalences in dairy and beef breeding cattle were 40.9 and 28.7%, respectively. By the time animals were 1 year old, 21.0% of dairy and 13.7% of beef breeding cattle were considered infected. Our findings indicate that BLV is widespread among dairy and beef breeding cattle in Japan with the BLV seroprevalences approximately 10-and 4-fold higher, respectively, than previously reported for 1980-1982 in Japan. KEY WORDS: bovine leukemia virus, cattle, nationwide survey, seroprevalence.

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“…Serological study All serum samples were analyzed for antibodies against BLV using blocking enzyme-linked immune sorbent assay (ELISA) kit, according to the instruction of the manufacturer, (ELISA Leukosis Blocking/BLV gp51 antibody test kit; Institut Pourquier, Montpellier, France). The sensitivity and specificity of the ELISA test were 99.0 and 99.6%, respectively (13). Both positive and negative control samples were provided in the kit.…”

Section: Leukocyte Countmentioning

confidence: 99%

“…Additionally, a hematological study was carried out to compare the results from the serology and to observe changes in blood parameters. Bovine leukemia virus infection occurs worldwide, but varies in prevalence between countries (13). The aim of the present study was to estimate the seroprevalence of BLV in certain areas of Iran.…”

Section: Introductionmentioning

confidence: 99%

A Serological Study on Bovine Leukemia Virus Infection in Ten Provinces of Iran between 2010 and 2012

et al. 2012

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Background and Aims: Bovine leukaemia virus (BLV) is an oncogenic member of the genus Deltaretrovirus of the family Retroviridae. BLV is the causative agent of enzootic bovine leukaemia and infects cattle worldwide, imposing economic impact on the dairy cattle industry. The purpose of this study was to estimate the seroprevalence of BLV in cattle in some provinces of Iran. Materials and Methods: A total of 280 cows over 2 years old from 10 provinces of Iran in different regions and environments from industrial and less industrial herds were used in the study. Blood samples from all cows were taken both with and without EDTA. Serum separation for the ELISA test and leukocyte count, were performed upon receipt without delay. Cattle without fever that had lymphocyte numbers of more than 9,000/μl were suspected to have persistent lymphocytosis (PL). Sera samples were examined for antibodies against BLV by blocking ELISA. Results: The seroprevalence of BLV among animals was 32.8% and among provinces was 80%. Seropositive cattle had higher total leukocyte and lymphocyte count and lower neutrophil count than seronegative cattle (P<0.001). Among BLV seropositive animals, the rate of PL was 36.9%. None of the seronegative animals showed lymphocytosis. Conclusion: Comparing the data with previous studies on seroprevalence of BLV in different localities in Iran, the prevalence of the infection has been raised. These results suggest that promoting control programs in Iran are very important. Furthermore, it will be essential to conduct nationwide surveillance program and determine the major risk factors.

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The eradication experience of enzootic bovine leukosis from Lithuania

Cited by 69 publications

References 19 publications

Association of TNF-α gene promoter region polymorphisms in bovine leukemia virus (BLV)-infected cattle with different proviral loads

Association of TNF-α gene promoter region polymorphisms in bovine leukemia virus (BLV)-infected cattle with different proviral loads

Nationwide Survey of Bovine Leukemia Virus Infection among Dairy and Beef Breeding Cattle in Japan from 2009–2011

A Serological Study on Bovine Leukemia Virus Infection in Ten Provinces of Iran between 2010 and 2012

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