The ERM protein Moesin is essential for neuronal morphogenesis and long-term memory in Drosophila

Freymuth, Patrick Stephen; Fitzsimons, Helen L.

doi:10.1186/s13041-017-0322-y

Cited by 22 publications

(21 citation statements)

References 63 publications

(97 reference statements)

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“…Furthermore, other studies have revealed that changes in dendritic complexity impaired LMC (Freymuth & Fitzsimons, 2017;Lee et al, 2017). Both the microinjection of dme-miR-92b antagomirs and overexpression of crebA in D. melanogaster did result in significant increase of LMC (Bi et al, 2019), further supporting a miRNA-target pathway that regulates the change of LMC in Drosophila induced by Wolbachia infection.…”

Section: Effect Of Wolbachia On Learning and Memory Capacity (Lmc) Inmentioning

confidence: 70%

The effect of the endosymbiont Wolbachia on the behavior of insect hosts

Wang

2019

Insect Science

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As one of the most successful intracellular symbiotic bacteria, Wolbachia can infect many arthropods and nematodes. Wolbachia infection usually affects the reproduction of their hosts to promote their own proliferation and transmission. Currently, most of the studies focus on the mechanisms of Wolbachia interactions with host reproduction. However, in addition to distribution in the reproductive tissues, Wolbachia also infect various somatic tissues of their hosts, including the brain. This raises the potential that Wolbachia may influence some somatic processes, such as behaviors in their hosts. So far, information about the effects of Wolbachia infection on host behavior is still very limited. The present review presents the current literature on different aspects of the influence of Wolbachia on various behaviors, including sleep, learning and memory, mating, feeding and aggression in their insect hosts. We then highlight ongoing scientific efforts in the field that need addressing to advance this field, which can have significant implications for further developing Wolbachia as environmentally friendly biocontrol agents to control insect‐borne diseases and agricultural pests.

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Section: Effect Of Wolbachia On Learning and Memory Capacity (Lmc) Inmentioning

confidence: 70%

The effect of the endosymbiont Wolbachia on the behavior of insect hosts

Wang

2019

Insect Science

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“…NKX6.3/HGTX over-expression also led to a reduction of whole-body triglyceride (TAG) content. While this was surprising, this observation is not uncommon in functional screens 60,61 and it suggests that a tight NKX6.3 / HGTX gene dosage is important to maintain TAG levels.…”

Section: Discussionmentioning

confidence: 91%

Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism

et al. 2019

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Hundreds of genetic variants have been associated with Body Mass Index (BMI) through genome-wide association studies (GWAS) using observational cohorts. However, the genetic contribution to efficient weight loss in response to dietary intervention remains unknown. We perform a GWAS in two large low-caloric diet intervention cohorts of obese participants. Two loci close to NKX6.3/MIR486 and RBSG4 are identified in the Canadian discovery cohort (n = 1166) and replicated in the DiOGenes cohort (n = 789). Modulation of HGTX (NKX6.3 ortholog) levels in Drosophila melanogaster leads to significantly altered triglyceride levels. Additional tissue-specific experiments demonstrate an action through the oenocytes, fly hepatocyte-like cells that regulate lipid metabolism. Our results identify genetic variants associated with the efficacy of weight loss in obese subjects and identify a role for NKX6.3 in lipid metabolism, and thereby possibly weight control.

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“…MSN can inhibit the function of RhoA and is closely associated with the Rac1 pathway [Freymuth & Fitzsimons, 2017]. MSNP1AS overexpression enhanced RhoA activity and downregulated Rac1 activity, whereas when MSNP1AS expression was inhibited, the activities of RhoA and Rac1 showed the opposite trend [Fig.…”

Section: Resultsmentioning

confidence: 99%

The Autism‐Related lncRNA MSNP1AS Regulates Moesin Protein to Influence the RhoA, Rac1, and PI3K/Akt Pathways and Regulate the Structure and Survival of Neurons

Luo

Cao

et al. 2020

Autism Research

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Autism spectrum disorder (ASD) is a complex disease involving multiple genes and multiple sites, and it is closely related to environmental factors. It has been gradually revealed that long noncoding RNAs (lncRNAs) may regulate the pathogenesis of ASD at the epigenetic level. In neuronal cells, the lncRNA moesin pseudogene 1 antisense (MSNP1AS) forms a double-stranded RNA with moesin (MSN) to suppress moesin protein expression. MSNP1AS overexpression can activate the RhoA pathway and inhibit the Rac1 and PI3K/Akt pathways; however, the regulation of Rac1 by MSNP1AS is not associated with MSN, and the effect on the RhoA pathway may also be associated with other factors. MSNP1AS can decrease the number and length of neurites, inhibit neuronal cell viability and migration, and promote apoptosis. Downregulation of MSN expression functions similarly to MSNP1AS, and its overexpression can block the above functions of MSNP1AS. In addition, in vivo experiments show that MSN improves social interactions and reduces repetitive behaviors in BTBR mice, decreases the activity of RhoA and restores the activity of PI3K/Akt pathway. Therefore, the abnormal expression of MSNP1AS in ASD patients might influence the structure and survival of neuronal cells through the regulation of moesin protein expression to facilitate the development and progression of ASD. These findings provide new evidence for studying the mechanisms of lncRNAs in ASD.

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The ERM protein Moesin is essential for neuronal morphogenesis and long-term memory in Drosophila

Cited by 22 publications

References 63 publications

The effect of the endosymbiont Wolbachia on the behavior of insect hosts

The effect of the endosymbiont Wolbachia on the behavior of insect hosts

Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism

The Autism‐Related lncRNA MSNP1AS Regulates Moesin Protein to Influence the RhoA, Rac1, and PI3K/Akt Pathways and Regulate the Structure and Survival of Neurons

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