The Erosion Properties of Polyanhydrides

Shieh, Lisa; Göpferich, Achim; Langer, Robert

doi:10.1557/proc-331-85

Cited by 5 publications

(5 citation statements)

References 7 publications

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“…PCL (MW 37 kDa) was purchased from Polysciences (Warrington, PA). Polyanhydrides (PCPP:SA, 50:50 and PFAD:SA 50:50) were obtained as generous gift from Dr. Robert Langer lab at MIT; PCPP:SA had Mn of 4.3 kDa and PFAD:SA had Mn of 40 kDa 30,31 . PEG‐co‐polyesters were obtained as generous gift from Dr. C.P.…”

Section: Methodsmentioning

confidence: 99%

Hemocompatibility of polymers for use in vascular endoluminal implants

Ammann

Hossainy

et al. 2021

J of Applied Polymer Sci

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Implanted polymers for cardiovascular applications may function as structural supports, barriers, or provide a means for local drug delivery. Several thermoplastic biodegradable drug delivery polymers are potential candidates for blood‐contacting implant applications. For intravascular applications specifically, a criterion for material selection is the intrinsic hemocompatibility of the baseline polymer. As an initial screening approach for selection of polymers for in vivo use, thin films of polyesters: poly(ɛ‐caprolactone) (PCL), poly(lactic acid) (PLA), poly(lactic‐co‐glycolic acid) (PLGA); polyanhydrides: poly(fatty acid dimer‐co‐sebacic acid) (PFAD:SA) and poly(biscarboxyphenoxypropane‐co‐sebacic acid) (PCPP:SA); and poly(ethylene glycol) (PEG)‐ylated polyesters: PLA:PEG, PCL:PEG and PCL:PLA:PEG polymers were spin‐cast on glass cover slips and placed in an in vitro flow system exposing them at a controlled shear to overflowing human whole blood. Platelet adherence, aggregate formation, and thrombus formation, as well as leukocyte adherence were assessed following 5 min of flow. At 5 min of flow the rank order of materials, in terms of least to most thrombogenic was: PCL < PFAD:SA < PCPP:SA < PLGA < PLA. All PEGylated materials, in general, had less thrombus formation than baseline unmodified materials.

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Section: Methodsmentioning

confidence: 99%

Hemocompatibility of polymers for use in vascular endoluminal implants

Ammann

Hossainy

et al. 2021

J of Applied Polymer Sci

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“…[ 74 ] Surface erosion during degradation inhibits pitting and cavity formation in the bulk material, making polyanhydrides promising materials for drug delivery applications. [ 75 ] A polyanhydride copolymer, consisting of 20% carboxyphenoxy propane and 80% sebacic acid was used in Gliadel (NDA 20‐637) brain tumor implants (Guilford Pharmaceuticals in 1996) for the controlled delivery of carmustine or bis‐chloroethylnitrosourea (BCNU). [ 76–77 ]…”

Section: Introductionmentioning

confidence: 99%

Enabling Proregenerative Medical Devices via Citrate‐Based Biomaterials: Transitioning from Inert to Regenerative Biomaterials

Wang,

Huddleston,

Yang

et al. 2023

Advanced Materials

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Regenerative medicine aims to restore tissue and organ function without the use of prosthetics and permanent implants. However, achieving this goal has been elusive, and the field remains mostly an academic discipline with few products widely used in clinical practice. From a materials science perspective, barriers include the lack of proregenerative biomaterials, a complex regulatory process to demonstrate safety and efficacy, and user adoption challenges. Although biomaterials, particularly biodegradable polymers, can play a major role in regenerative medicine, their suboptimal mechanical and degradation properties often limit their use, and they do not support inherent biological processes that facilitate tissue regeneration. As of 2020, nine synthetic biodegradable polymers used in medical devices are cleared or approved for use in the United States of America. Despite the limitations in the design, production, and marketing of these devices, this small number of biodegradable polymers has dominated the resorbable medical device market for the past 50 years. This perspective will review the history and applications of biodegradable polymers used in medical devices, highlight the need and requirements for regenerative biomaterials, and discuss the path behind the recent successful introduction of citrate‐based biomaterials for manufacturing innovative medical products aimed at improving the outcome of musculoskeletal surgeries.

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“…Langer, Göpferich and others have extensively evaluated degradation in polyanhydrides due to the hydrolytic lability of the anhydride bond 10, 18–32 as the highly hydrophobic nature of these polymers makes them ideal candidates for drug delivery applications. 24, 31–51 The hydrophobicity prohibits water from effectively permeating the polymer matrix so that the rate of hydrolysis is faster than the rate of water diffusion into the matrix.…”

Section: Introductionmentioning

confidence: 99%

“…A direct consequence of this phenomenon is that these polymers predominantly undergo surface erosion. 30–32, 51…”

Section: Introductionmentioning

confidence: 99%

Poly(anhydride‐ester) fibers: Role of copolymer composition on hydrolytic degradation and mechanical properties

Whitaker-Brothers

Uhrich

2004

J Biomedical Materials Res

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Poly(anhydride-esters), based on carboxyphenoxydecanoate (CPD), are biocompatible polymers that hydrolytically degrade. The mechanical properties of the poly(anhydride-esters) can be altered by copolymerization with para-carboxyphenoxyhexane (pCPH). Mechanical properties of three CPD:pCPH compositions (30:70, 40:60, and 50:50) are reported as a function of hydrolytic degradation. The mechanical characteristics evaluated were tensile modulus at 1% strain (E(1%)), tensile strength (sigma(B)), ultimate elongation (epsilon(B)), and toughness (E(r)). The 30:70 CPD:pCPH fibers maintained higher values for tensile modulus at all time points than the two other fiber compositions. In addition, the 30:70 CPD:pCPH fibers maintained lower values for both tensile strength and toughness than the two other fiber compositions. These phenomena resulted from the brittle nature of pCPH, the major component of the 30:70 CPD:pCPH fibers; increasing the pCPH concentration in the polymer lowers both tensile strength and toughness of the polymer by decreasing ductility. With increasing amounts of pCPH, the hydrolytic degradation occurred more slowly, as reflected in the copolymers' improved ability to retain their mechanical properties. Therefore, copolymerization is useful for controlling the mechanical properties of the fibers as well as the polymer degradation rate, which ultimately determines the rate at which physically or chemically encapsulated drugs can be released.

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The Erosion Properties of Polyanhydrides

Cited by 5 publications

References 7 publications

Hemocompatibility of polymers for use in vascular endoluminal implants

Hemocompatibility of polymers for use in vascular endoluminal implants

Enabling Proregenerative Medical Devices via Citrate‐Based Biomaterials: Transitioning from Inert to Regenerative Biomaterials

Poly(anhydride‐ester) fibers: Role of copolymer composition on hydrolytic degradation and mechanical properties

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