2015
DOI: 10.1097/shk.0000000000000364
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The ERRor of Our Ways

Abstract: As with sharks and horseshoe crabs, some designs of nature need only minor evolutionary adjustments during the millennia to remain superbly adapted. Such is the case at the molecular level for the nuclear receptors (NRs), which seem to have originated concomitantly with the earliest metazoan lineage of animals. A wide array of NRs persists today throughout all animal phyla with many different functions, yet they share a highly conserved protein structure, a testament to their having evolved through numerous ge… Show more

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Cited by 10 publications
(2 citation statements)
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References 111 publications
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“…So far, most previous studies of ESRR actions have focused on its role in cancer progression and this topic has been reviewed elsewhere [24][25][26][27][28][29][30][31][32][33][34][35]. There have also been a few studies on its roles in bone and muscle differentiation [36][37][38], trauma/shock [39], and infection [40]. The physiological and metabolic roles of ESRRA in vivo have only been appreciated recently and are still not fully understood.…”
Section: Introductionmentioning
confidence: 99%
“…So far, most previous studies of ESRR actions have focused on its role in cancer progression and this topic has been reviewed elsewhere [24][25][26][27][28][29][30][31][32][33][34][35]. There have also been a few studies on its roles in bone and muscle differentiation [36][37][38], trauma/shock [39], and infection [40]. The physiological and metabolic roles of ESRRA in vivo have only been appreciated recently and are still not fully understood.…”
Section: Introductionmentioning
confidence: 99%
“…In vertebrates, there are three subtypes of estrogen-related receptors (ERRs), namely ERRα, ERRβ, and ERRγ [2]. ERRs are widely distributed across vertebrates and play crucial roles in regulating various processes related to nutrient breakdown and energy metabolism in mammals [1,[3][4][5][6]. Their expression is highly correlated with mitochondrial biogenesis [7] and oxidative phosphorylation, participating in lipid metabolism, glucose metabolism, and oxidative phosphorylation pathways [8].…”
Section: Introductionmentioning
confidence: 99%