The essential oil of Mongolian<i>Nepeta sibirica</i>: a single component and its biological activities

Tsuruoka, Tsutomu; Davaapurev, Bekh-Ochir; Kato, Fumio; Shatar, Sanduin; Altantsetseg, Shataryn; Ayurzana, Amarjargal; Satou, Tadaaki; Li, Wei; Koike, Kazuo

doi:10.1080/10412905.2012.729925

Cited by 18 publications

(10 citation statements)

References 6 publications

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“…Cisplatin was used as a positive control and for 72 h treatment exhibited the IC 50 values in the following concentration range 0.99-4.29 μg/mL in the investigated cell lines. IC 50 values of some other tested EOs obtained from various Nepeta species ranged from 10 − 50 μg/mL (Tsuruoka et al, 2012;Kahkeshani et al, 2014;Shakeri et al, 2014Shakeri et al, , 2016. Essential oil from N.sibirica, rich in cis,trans-nepetalactone, showed cytotoxic effectson human leukemia myeloid-derived cell line HL-60 and on stomach adenocarcinoma Kato III, but was not cytotoxic to the lung adenocarcinoma cell line A549 (Tsuruoka et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, these plants have shown antiviral, phytotoxic and allelopathiceffects (Kobaisy et al, 2005;Formisano et al, 2011;Dmitrović et al,2015;Nestorović Zivković et al, 2016). Several studies investigatedthe cytostatic and cytotoxic activities of various Nepeta species Tsuruoka et al, 2012;Kahkeshani et al, 2014;Shakeri et al, 2014Shakeri et al, , 2016. The majority of aforementioned bio-logical activities of Nepeta species are ascribed to nepetalactones,cyclopentanoid monoterpenes which are usually the main con-stituents of the essential oils (Birkett et al, 2011;Formisano et al,2011;Stojanović et al, 2005;Nestorović et al, 2010;Kumar et al,2014;Mišić et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…There are scarce literature data concerning cytotoxic activitiesof EOs of some other Nepeta species with considerable amounts ofdiverse nepetalactones (Shakeri et al, 2016;Tsuruoka et al, 2012;Kahkeshani et al, 2014) or germacrene D (Shakeri et al, 2014), and1,8-cineol (Kahkeshani et al, 2014). However, detailed knowledgeabout the mode of action of these EOs is still lacking.…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxic activity of Nepeta rtanjensis Diklić & Milojević essential oil and its mode of action

Škorić

Gligorijević

Čavić

et al. 2017

Industrial Crops and Products

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Nepeta rtanjensis Diklić & Milojević (fam. Lamiaceae) is an endemic, critically endangered plant, protectedby the law in Serbia. Various biological activities have been ascribed to its major constituents, nepeta-lactones. In this study we describe for the first time cytotoxic activity of N. rtanjensis essential oil (EO),obtained from field cultivated plants, which was found to be especially rich in trans,cis-nepetalactone.MTT assays indicated that after 72 h of treatment the EO exhibited cytotoxic activity on investigatedcancer cell lines: HeLa, K562, A549, LS-174 and MDA-MB-231. Normal cell line (MRC-5) was the leastsensitive to the treatment and IC50value for this cell line was not reached within the tested range ofEO concentrations (up to 0.1 L/mL). Analysis of morphological changes of treated cells confirmed thehigher sensitivity of tumor cells than normal cells to the tested EO. Application of N. rtanjensis EO resultedin the appearance of morphological changes in tested cancer cell lines characteristic for apoptotic celldeath, and induced perturbations of the cell cycle of HeLa cells. In addition, upregulation of Bax and p53,and downregulation of Bcl-2, and Skp2 genes, involved in apoptotic signalling cascades, confirmed anapoptosis-inducing effect of N. rtanjensis EO on HeLa cells. Presented results highlighted the potential ofN. rtanjensis EO in anticancer therapy.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cytotoxic activity of Nepeta rtanjensis Diklić & Milojević essential oil and its mode of action

Škorić

Gligorijević

Čavić

et al. 2017

Industrial Crops and Products

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“…It was documented that nepetalactones were the predominant components responsible for the feline attractant properties of many Nepeta species, such as N. persica, N. pogonosperma, N. racemosa, N. cataria, N. sibirica, N. nuda, N. grandifolia, N. clarkei, N. argolica and N. crassifolia. [34][35][36][37][38][39][40][41] For instance, 4aα,7α,7aβ-nepetalactone (28.8%) and 4aα, 7β,7aα-nepetalactone (11.9%) were reported the major components of Nepeta cataria essential oil. [41] Tittel et al [42] reported that the main constituents of N. cataria var.…”

Section: Resultsmentioning

confidence: 99%

Essential oil composition of seven populations belonging to twoNepetaspecies from Northwestern Iran

Narimani

Moghaddam

Pirbalouti

et al. 2017

International Journal of Food Properties

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Essential oils from the aerial parts of three populations of Nepeta crassifolia (Lamiaceae), which are Iranian endemic species and four populations of N. nuda grown in northwestern Iran were obtained by hydro-distillation and examined by gas chromatography (GC) and GC-mass spectrometry (GC/ MS). Overall, 37 compounds were identified in the essential oils from different populations of N. crassifolia and N. nuda. The essential oils consisted mainly of oxygenated monoterpenes and sesquiterpene aldehydes. The major components in the oils of three populations of N. crassifolia were 4aβ, 7α, 7aβ-nepetalactone (16.46-27.45%), 4aα, 7α, 7aβ-nepetalactone (13.45-17.54%), 1,8-cineole (8.15-9.70%) and elemol (14.38-22.14%), while 7aβ-nepetalactone (61-72.21%), 4aα, 7α, 7aβ-nepetalactone (8.72-12.63%), pulegone (7.36%) and piperitenone oxide (4.12%) were identified as the main constituents in the oils of four populations of N. nuda. The essential oils from the aerial parts of two species of Nepeta sourced in northwestern Iran were rich in oxygenated monoterpenes. In conclusion, the present study indicated the essential oil components of wild populations of both Nepeta species varied with chemotypes, environmental conditions, and geographic origin.

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“…The presence of diverse classes of terpenes in different species of the genus Nepeta and some data related to the cytotoxicity of some of these compounds such as nepetalactone (iridoid), ursolic acid (triterpene), and nepetolide (diterpene) directed us to examine total sterol, total iroid, and total triterpenoid content of these species [ 31 , 32 , 33 ]. In addition, ursolic acid content was quantitatively analyzed by HPLC-PDA.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Effects of Some Nepeta Species against Breast Cancer Cell Lines and Their Associated Phytochemical Properties

Şafak

Karatoprak

Dırmencı

et al. 2022

Plants

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Nepeta is one of the largest genera of the Lamiaceae family. Nepeta species are commonly employed in traditional medicine for a variety of ailments, as well as food additives. In addition, they also come to the fore with their rich phytochemical content. In the present study, the quantitative phytochemical content of methanolic extracts and infusions prepared from the aerial parts of 14 Nepeta taxa collected from Turkey and their cytotoxic effects on two breast cancer cell lines, MCF-7 and MDA-MB-231, were investigated by using the MTT (3-(4,5-dimethylthiazol-2-yl))-2,5-diphenyltetrazolium-bromide) test. According to HPLC-PDA analysis, N. racemosa methanolic extract had the highest ursolic acid content with 165.9 mg/g extract. Total sterol, total iridoid, and total triterpenoid content were determined to be greatest in the methanolic extracts of N. meyeri, N. trichocalyx and N. phyllochlamys. The MTT experiment demonstrated that certain Nepeta species suppressed the growth of MCF-7 and MDA-MB-231 cells in a dose-dependent manner. Statistical analysis revealed a strong correlation between the cytotoxic effects of the extracts and their triterpene content. In conclusion, the data obtained from this study are important in terms of forming a basis for advanced anticancer activity studies on breast cancer with Nepeta sp.

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The essential oil of MongolianNepeta sibirica: a single component and its biological activities

Cited by 18 publications

References 6 publications

Cytotoxic activity of Nepeta rtanjensis Diklić & Milojević essential oil and its mode of action

Cytotoxic activity of Nepeta rtanjensis Diklić & Milojević essential oil and its mode of action

Essential oil composition of seven populations belonging to twoNepetaspecies from Northwestern Iran

Cytotoxic Effects of Some Nepeta Species against Breast Cancer Cell Lines and Their Associated Phytochemical Properties

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