The Estrogen and Progesterone Receptors in Endometrial Carcinoma - An Update

Dasgupta, ira

doi:10.15406/emij.2017.05.00120

Cited by 2 publications

(2 citation statements)

References 53 publications

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“…In a study of breast cancer cells, they investigated the effect of DHT on progesterone receptors [ 45 ]. Progesterone receptor A (PR-A) and progesterone receptor B (PR-B) have antagonistic effects in endometrium, since PR-A modulates the anti-proliferative effects of progesterone in the uterus and PR-B in the absence of PR-A leads to cell growth [ 46 ]. In the mentioned study, they came to the conclusion that DHT had some transcriptional activity through PR-B, but not through PR-A [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

What Role do Androgens Play in Endometrial Cancer?

Maček

Molinari

Sobočan

et al. 2023

JPM

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The role of estrogens and progesterone in the development and progression of endometrial cancer is well-established, but there are very little data about the role of androgens. There are five different androgens produced in women: dehydroepiandrosterone sulphate (DHEAS), dehydroepiandrosterone (DHEA), androstenedione (A4), testosterone (T) and dihydrotestosterone (DHT). The most potent hormones are T and DHT, the latter being mainly produced from T in peripheral tissues, including endometrium. Although they are considered to exert antiproliferative effects in many settings and the expression of their receptors is more often associated with a good prognosis in EC, it is still unknown in which specific settings androgens have carcinogenic or protective effects in EC.

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Section: Discussionmentioning

confidence: 99%

What Role do Androgens Play in Endometrial Cancer?

Maček

Molinari

Sobočan

et al. 2023

JPM

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“…Progestins act as powerful antiestrogens by helping to convert estradiol to estrone sulfate that rapidly gets cleared from the body. Furthermore, progestins antagonize estrogen action by inhibiting estrogen's induction of its receptors 18 . This hypoestrogenic state is thought to regress AVM.…”

Section: Discussionmentioning

confidence: 99%

Uterine arteriovenous malformation: A rare yet perilous entity.

Mannan

Niaz

Hayat³

et al. 2021

Int. j. endorsing health sci. res.

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Background: Uterine Arteriovenous Malformation (AVM) is a rare diagnosis. Although rare, it can cause massive and life-threatening hemorrhage, eventually leading to considerable morbidity and mortality. Healthcare professionals need to have a high index of suspicion in order to avoid the morbidity associated with Uterine Arteriovenous Malformation. We shed light on this relatively under-researched gynecologic diagnosis. Case Presentation: We describe the presentation, workup, including radiological studies, and subsequent management of Uterine Arteriovenous Malformation in two reproductive-age females who presented to our hospital with abnormal vaginal bleeding. Both patients had a history of primary hemorrhage after abortion, requiring blood transfusion. Both patients underwent Magnetic resonance imaging (MRI) and showed a tortuous serpentine tangle of mixed signals extending from the deep myometrium into the endometrium. Management & Results: Diagnosis of Uterine AVM was established months later when they presented with continuous abnormal vaginal bleeding. The diagnosis was established based on clinical examination and imaging studies. Patients were managed with hormonal treatment and responded well; one of them eventually got a successful pregnancy. Conclusion: Uterine arteriovenous malformation, causing significant vaginal bleeding, can be managed timely with accurate diagnosis and prompt management, with an array of modalities including conservative, medical or surgical methods. The modality of treatment depends upon the patient’s clinical condition and fertility wishes.

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The Estrogen and Progesterone Receptors in Endometrial Carcinoma - An Update

Cited by 2 publications

References 53 publications

What Role do Androgens Play in Endometrial Cancer?

What Role do Androgens Play in Endometrial Cancer?

Uterine arteriovenous malformation: A rare yet perilous entity.

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