The etiology, manifestations, and therapy of chronic cerebrovascular diseases

Gogoleva, A.G.; Захаров, Владимир

doi:10.14412/2074-2711-2020-5-84-91

Cited by 13 publications

(1 citation statement)

References 54 publications

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“…В настоящее время большой интерес врачей и исследователей вызывают недавно описанные плейотропные эффекты классического антиагрегантного препарата дипиридамол (Курантил ® ) [75]. Дипиридамол ингибирует фермент фосфодиэстеразу в тромбоцитах и, следовательно, увеличивает интратромбоцитарные уровни циклического аденозинмонофосфата и циклического гуанозинмонофосфата, тем самым угнетая агрегацию тромбоцитов и усиливая ингиби- [80].…”

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Management tactics in patients with chronic cerebral ischemia during COVID-19 pandemic

Кулеш

2021

RJTAO

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The article describes the current state of evidence of hypertension and diabetes mellitus roles in the pathophysiology of chronic cerebral ischemia (CCI). CCI is mediated by cerebral microangiopathy, which develops due to vascular remodeling, increased arterial stiffness, endothelial dysfunction, impaired cerebrovascular reactivity, and neuroinflammation. All those mechanisms lead to white matter lesions and cognitive impairment. Arteriolosclerosis is the primary morphological process that damages perforating arteries and arterioles. COVID-19 pandemic can modify CCI progression due to similar pathophysiology. In particular, COVID-19-associated coagulopathy can lead to silent lacunar infarctions and lacunar stroke development. Treatment features of patients with CCI during the COVID-19 pandemic are reviewed. It is concluded that special attention in this group of patients should be paid to primary and secondary cardiovascular prevention issues, an essential element of which is the use of dipyridamole since it has a pleiotropic effect.

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Management tactics in patients with chronic cerebral ischemia during COVID-19 pandemic

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2021

RJTAO

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Brain Aging

Cherdak

2023

Adv Gerontol

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Heterogeneity of the mild cognitive impairment syndrome (specialized outpatient service data analysis)

Локшина

Захаров

Grishina

et al. 2021

RJTAO

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Timely diagnosis and optimal management of patients with cognitive impairment (CI) without dementia can potentially reduce the risk of their progression to dementia. In our study, we assessed the features of mild CI (MCI) syndrome in patients with neurological disorders based on the specialized outpatient service data analysis.Objective: to analyze clinical, neuropsychological, and neuroimaging characteristics of MCI syndrome in the Russian population in real clinical practice.Patients and methods. We enrolled 515 patients (209 men and 306 women, mean age – 71.2±8.0 years) with memory and/or other cognitive complaints. Seventy healthy volunteers (25 men and 45 women, mean age – 69.5±5.71 years) without cognitive complaints and central nervous system or mental disorders were enrolled in the control group. DSM-V diagnostic criteria for mild neurocognitive disorder were used. Participants underwent comprehensive neuropsychological testing with a qualitative and quantitative assessment of the results. In some of them (29.13%), brain magnetic resonance imaging (MRI) was performed.Results and discussion. The following types of MCI were identified in study participants: monofunctional non-amnestic type (MFNAT) – 1.2%, monofunctional amnestic type (MFAT) – 12.6%, polyfunctional amnestic type (PFAT) – 22.9%, polyfunctional non-amnestic type (PFNAT) – 63.3%. We found a higher prevalence of executive dysfunction and attention deficit in PFNAT, and executive dysfunction, attention deficit, and memory decline in PFAT. Cardiovascular risk factors and signs of vascular leukoencephalopathy on MRI were more frequently observed in PFNAT and PFAT.Conclusion. The clinical and neuropsychological analysis allows us to assume the pathophysiology of CI before the development of dementia. In the Russian population, cerebrovascular insufficiency plays a significant role in the development of MCI syndrome.

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The etiology, manifestations, and therapy of chronic cerebrovascular diseases

Cited by 13 publications

References 54 publications

Management tactics in patients with chronic cerebral ischemia during COVID-19 pandemic

Management tactics in patients with chronic cerebral ischemia during COVID-19 pandemic

Brain Aging

Heterogeneity of the mild cognitive impairment syndrome (specialized outpatient service data analysis)

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