The Etiology of Primary Granulocytopenia (Agranulocytic Angina)

Agranulocytosis and systemic candidiasis following clomipramine therapy

“…Later Madison and Squier (1934) recognized amidopyrine as the offending drug. There appear to be at least two mechanisms of drug induced agranulocytosis (Pisciotta, 1973).…”

Hypersensitivity to pyrazolones

“…In 1934 it was shown by rechallenge that amidopyrine was a cause of the disease 31. In the 1950s evidence for the immunological pathogenesis of amidopyrine induced agranulocytosis was provided by Moeschlin and Wagner 32…”

The Relationship of Drug Therapy to Agranulocytosis

“…In 1933 deVries 18 reported from Holland one case following the administration of amidopyrine. These reports were then followed by that of Madison and Squier 19 in which they pointed out that all fourteen of their patients had developed the disease after the use of amidopyrine or one of its combinations. Following their report, Watkins 20 restudied the cases of agranu¬ locytosis seen at the Mayo Clinic and found that thir¬ teen of these had apparently followed the administration of amidopyrine.…”