The European Union (EU) has been a remarkable example of regional integration to achieve economic and security prosperity. In the last decade, this most uniformed organisation has faced several challenges, such as the migration crisis, Brexit, and the global pandemic. Now, Europe has itself been involved in a huge regional conflict after Russia attacked Ukraine in late February 2022. Prior to the Ukraine-Russia war, the EU had already lost its position in Afghanistan after the Taliban takeover. Since 9/11, the EU has been a top aid donor to Afghanistan with the purpose of achieving regional stability, and yet the nonstate security threat in South Asia is still a big issue. The concerns of regional conflicts, such as peace, promotion of human rights, and democracy in Europe and the world, have been a challenge to the EU's global aspiration. Having said that, this chapter aims to deal with the above concerns vis-à-vis issues of global challenges in the shadow of major conflicts, threats, and opportunities.