The EU endocrine disruptors’ regulation and the glyphosate controversy

Kalofiri, Paraskevi; Balias, Giorgos; Tekos, Fotios

doi:10.1016/j.toxrep.2021.05.013

Cited by 27 publications

(9 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, Dallegrave et al ( 16 ) demonstrated that lactational exposure to glyphosate in animals impacts their reproductive system in puberty and adulthood by causing a reduction in sperm counts and testosterone levels. Such studies corroborate others that discuss glyphosate as an endocrine-disrupting chemical ( 17 - 19 ). These findings indicate the potential of glyphosate for endocrine disruption and reinforce the need for more studies to understand the implications of its chronic exposure through lactation on child development.…”

Section: Discussionsupporting

confidence: 87%

Determination of glyphosate in breast milk of lactating women in a rural area from Paraná state, Brazil

Camiccia

Candiotto

Gaboardi

et al. 2022

Braz J Med Biol Res

View full text Add to dashboard Cite

The aim of this study was to verify the presence of glyphosate in breast milk and to characterize maternal environmental exposure. Sixty-seven milk samples were collected from lactating women in the city of Francisco Beltrão, Paraná, living in urban (n=26) and rural (n=41) areas, at the peak of glyphosate application in corn and soy crops in the region (April and May 2018). To characterize the study population, socio-epidemiological data of the women were collected. To determine glyphosate levels, a commercial enzyme immunosorbent assay kit was used. Glyphosate was detected in all breast milk samples analyzed with a mean value of 1.45 mg/L. Despite some descriptive differences, there were no statistically significant differences (Po0.05) between the categories of the variables tested. Also, glyphosate was detected in drinking water samples from the urban area and in artesian well water from the rural area of the region where the studied population lived. The estimation of the total amount of glyphosate ingested by breastfeeding babies in a period of 6 months was significant. These results suggest that the studied lactating population was contaminated with glyphosate, possibly through continued environmental exposure.

show abstract

Section: Discussionsupporting

confidence: 87%

Determination of glyphosate in breast milk of lactating women in a rural area from Paraná state, Brazil

Camiccia

Candiotto

Gaboardi

et al. 2022

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…Overall, human exposure data in the EU are limited [ 5 ] and health effects, especially cancer, remain unclear up to this point. IARC has classified Gly as probably carcinogenic (Group 2A) [ 6 ], while the EU regulatory agencies consider its aquatic toxicity as the basis for regulation [ 7 ]. More human exposure data and epidemiological studies analysing associations with health effects are warranted.…”

Section: Introductionmentioning

confidence: 99%

Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B Adults

Buekers

Remy

Bessems

et al. 2022

Toxics

View full text Add to dashboard Cite

Within HBM4EU, human biomonitoring (HBM) studies measuring glyphosate (Gly) and aminomethylphosphonic acid (AMPA) in urine samples from the general adult population were aligned and quality-controlled/assured. Data from four studies (ESB Germany (2015–2020); Swiss HBM4EU study (2020); DIET-HBM Iceland (2019–2020); ESTEBAN France (2014–2016)) were included representing Northern and Western Europe. Overall, median values were below the reported quantification limits (LOQs) (0.05–0.1 µg/L). The 95th percentiles (P95) ranged between 0.24 and 0.37 µg/L urine for Gly and between 0.21 and 0.38 µg/L for AMPA. Lower values were observed in adults compared to children. Indications exist for autonomous sources of AMPA in the environment. As for children, reversed dosimetry calculations based on HBM data in adults did not lead to exceedances of the ADI (proposed acceptable daily intake of EFSA for Gly 0.1 mg/kg bw/day based on histopathological findings in the salivary gland of rats) indicating no human health risks in the studied populations at the moment. However, the controversy on carcinogenicity, potential endocrine effects and the absence of a group ADI for Gly and AMPA induce uncertainty to the risk assessment. Exposure determinant analysis showed few significant associations. More data on specific subgroups, such as those occupationally exposed or living close to agricultural fields or with certain consumption patterns (vegetarian, vegan, organic food, high cereal consumer), are needed to evaluate major exposure sources.

show abstract

“…EDs are frequently employed in the industry and agriculture, contributing significantly to environmental pollution due to their long decomposition periods, ranging from many hours to several days or months [15,44,45]. Among EDs, ATR stands out for its fairly long half-life (95-350 days) and chemical stability, representing the most frequently detected pesticide in surface and groundwater [46]. Thus, human beings face a new challenge due to the high risk of adverse health outcomes.…”

Section: Discussionmentioning

confidence: 99%

Toxic Effects of Endocrine Disruptor Exposure on Collagen-Induced Arthritis

et al. 2022

View full text Add to dashboard Cite

Endocrine disruptors (EDs) are chemical substances capable of affecting endocrine system functioning and interfering with organ morphogenesis and physiological functions. The development and regeneration of bone tissues have a complex hormonal regulation, and therefore, bone tissue cells can be considered potential targets for endocrine disruptors. In that regard, the aim of this research was to investigate the impact of ED exposure on the inflammatory response and oxidative stress in an experimental model of collagen-induced arthritis (CIA). Arthritis was induced by an emulsion of type II collagen (CII) and complete Freund’s adjuvant, which was administered intradermally on days 0 and 21. Mice from day 21 to day 35 received the following EDs by oral gavage: cypermethrin (CP), diethyl phthalate (DEP), vinclozolin (VCZ), 17α-ethinylestradiol (EE), perfluorooctanesulfonic acid (PFOS) and atrazine (ATR). ED exposure caused worsening of clinical signs (erythema and edema in the hind paws), histological and radiographic changes, as well as behavioral deficits, induced by CII injections. Furthermore, ED exposure significantly increased the degree of inflammation and oxidative damage induced by arthritis; this upregulation was more evident after exposure to ATR than to other EDs. The results from our study suggest that exposure to EDs may play a deleterious role in the progression of RA; therefore, exposure to EDs should be limited.

show abstract

The EU endocrine disruptors’ regulation and the glyphosate controversy

Abstract: Highlights Endocrine disruptors are compounds that alter the functioning of the endocrine system of humans and wildlife. Regulation 2017/2100 and Regulation 2018/605. Glyphosate as Endocrine Disruptor. EU EDs Regulation and pesticide legislation.

Cited by 27 publications

References 43 publications

Determination of glyphosate in breast milk of lactating women in a rural area from Paraná state, Brazil

Determination of glyphosate in breast milk of lactating women in a rural area from Paraná state, Brazil

Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B Adults

Toxic Effects of Endocrine Disruptor Exposure on Collagen-Induced Arthritis

Contact Info

Product

Resources

About