2008
DOI: 10.1016/j.jaci.2008.07.030
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The European Union CREATE Project: A model for international standardization of allergy diagnostics and vaccines

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Cited by 101 publications
(76 citation statements)
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“…We should also consider that within the CREATE project 12, no consensus was achieved for any of the main allergens of HDM, even though Der p 2 reached a high reproducibility 21. Our native control extracts for group 1 showed a high reproducibility; however, that was not true for group 2.…”
Section: Discussionmentioning
confidence: 76%
See 1 more Smart Citation
“…We should also consider that within the CREATE project 12, no consensus was achieved for any of the main allergens of HDM, even though Der p 2 reached a high reproducibility 21. Our native control extracts for group 1 showed a high reproducibility; however, that was not true for group 2.…”
Section: Discussionmentioning
confidence: 76%
“…Knowing the allergen content of each therapeutic product is a critical point; however, a fully standardized assessment of allergens is not yet available in Europe despite the efforts of the CREATE project 12. Only some specific techniques and materials are recognized by such project as candidates to be used as standards 13.…”
mentioning
confidence: 99%
“…Moreover, the utilization of fungal extracts in AIT is hindered by enormous fungal species and the lack of information on the degree of exposure to many molds [25]. There is an absence of commercial extracts for many of the frequent fungi due to not growing on artificial media [26]. Published studies have also major limitations, including lack of placebo control, open design, utilization of unstandardized extracts, short follow-up time, or not have of a baseline observation periods [15].…”
Section: Limitations To Immunotherapymentioning
confidence: 99%
“…In 1999, the WHO/International Union of Immunological Societies Allergen Standardization Subcommittee initiated a specific program aimed to develop highly purified allergens that could be used for the standardization of in vitro assays which is the underlying issue in the implementation of this approach. This provided the genesis for a European Union-funded study entitled ''Development of certified reference materials for allergenic products and validation of methods for their quantification'' (acronym: CREATE) (van Ree et al, 2008). The aim of the European Union CREATE project was to produce international standards of purified allergens with verifiable allergen content.…”
Section: International Efforts To Standardized Allergensmentioning
confidence: 99%
“…Allergen products require registration by government institutions (Becker et al, 2006), such as the FDA in the United States and the Paul Ehrlich Institute in Germany. Basic researchers, physicians, regulatory authorities and manufacturers have long tried to define a common methodology to standardize allergen vaccines (Terho and Frew, 1995;van Ree et al, 2008) The quality of mite and pollen allergen extracts is better defined today than it was in the past, and the quality of food and epithelial allergen extracts has also improved (FernandezCaldas et al, 2006;Ferrer et al, 2005). However, further improvement is needed, particularly for food allergen extracts, since preliminary studies have shown efficacy also in this hiimpact clinical application, using sublingual food allergen extracts (Enrique et al, 2005).…”
Section: Introductionmentioning
confidence: 99%