Vocational high secondary school teachers need to update their knowledge to support their teaching and learning. This article aims to investigate the challenge of vocational secondary high school teacher in responding the development of information and communication technology (ICT) and the globalization era. A total of 51 teachers and novice teachers in Soloraya were enrolled in this study. The data were collected using questionnaire Likert scale that was downloaded and translated from a survey for measuring 21st century teaching and learning, West Virginia Department of Education. Regression analysis was used to analyze the significance of correlation between student's learning and teacher's statement. The finding indicated that there was no statistically significant correlation between student's learning and teacher's statement (F = .16, p > .05), there was no statistically significant the correlation between student's learning and teacher's statement on global connection (F = .16, p > .05), there was no statistically significant correlation between student's learning and teacher's statement on local connection (F = .65, p > .05), and there was no statistically significant correlation between student's learning and teacher's statement on using technology as a tool for learning (F = 1.36, p > .05). In addition, teachers are the major factor in learning process. They must update their knowledge of global connection, local connection and technology as a tool for learning. Teachers must have many designs of teaching. Students need practical experience in real work environment of global connection, local connection, and technology as a tool for learning. Learning by doing in the real work environment is more impression/ effective than just theoretical learning only.