The Evaluation of a Nasal Decongestant Preparation

Weisberg, Jerry; Breslow, Irwin

doi:10.1001/archotol.1966.00760020479014

Cited by 8 publications

(2 citation statements)

References 6 publications

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“…Phenylpropanolamine has proved beneficial for these indications, even when administered alone (Weisberg & Breslow, 1966). Since both antihistamines and phenylpropanolamine may affect sleep (Reinberg et al, 1978), and since this could be related to altered early morning performance, the effects of the drugs on subjective appraisals of sleep were also studied.…”

Section: Introductionmentioning

confidence: 99%

“…In addition to antihistamines, we deemed it appropriate to include phenylpropanolamine in the study, because sympathomimetic drugs are often combined with antihistamines to enhance symptomatic relief in vasomotor and allergic rhinitis. Phenylpropanolamine has proved beneficial for these indications, even when administered alone (Weisberg & Breslow, 1966). Since both antihistamines and phenylpropanolamine may affect sleep (Reinberg et al, 1978), and since this could be related to altered early morning performance, the effects of the drugs on subjective appraisals of sleep were also studied.…”

Section: Introductionmentioning

confidence: 99%

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Single and repeated dose comparison of three antihistamines and phenylpropanolamine: psychomotor performance and subjective appraisals of sleep.

Seppαlä¹,

Nuotto²,

Korttila³

1981

Brit J Clinical Pharma

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1 In a double-blind cross-over study, nine healthy male students received placebo, brompheniramine 12 mg), carbinoxamine (12 mg), clemastine (1 mg), and phenylpropanolamine (50 mg) orally. Three doses of each drug were given: at 08.30 h and 21.00 h on the first day of treatment and at 08.30 h on the following day. 2 Psychomotor skills and subjective feelings were recorded before and 2, 6 and 12 h after the first dose on day 1 as well as before and 2 and 6 h after the third dose on day 2. Subjective appraisals of sleep were requested on the morning of day 2. 3 All antihistamines tended to cause subjective drowsiness on the first day of treatment. Drowsiness was felt for a maximum of 2 h after carbinoxamine, 6 h after brompheniramine, and 12 h after clemastine. In contrast to antihistamines, phenylpropanolamine made subjects more alert and quick witted. Tolerance to the antihistamine-induced drowsiness developed on the second day. 4 Divided attention, tracking, speed anticipation and sleep were not affected by any drug. Carbinoxamine slowed reactions 2 h after the first dose, but no impairment was measured in objective tests after brompheniramine or clemastine. 5 Phenylpropanolamine improved reaction speed and reaction accuracy and enhanced flicker recognition throughout the study. Phenylpropanolamine plasma levels and improvement in flicker fusion test results correlated with each other on day 2. 6 The results suggest that phenylpropanolamine and the antihistamines studied are comparatively harmless to psychomotor performance and driving skills.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%