The Evaluation of Bone Formation of the Whole-Tissue Periosteum Transplantation in Combination With β-Tricalcium Phosphate (TCP)

Abstract

We investigated the osteogenic potential of a combination graft of beta-tricalcium phosphate (TCP) and periosteum in the rat calvarial defect model. The combination beta-TCP and periosteum graft was grafted into rat calvarial defects; the newly formed bone in the defect was studied histologically and radiographically and compared with periosteum grafts and TCP grafts. Ten days after combination grafting, the grafted periosteum showed cell proliferation and Runx2 immunoreaction; 20 days after grafting, new bone formation was seen around the beta-TCP; and 30 days after grafting, new bone developed and actively replaced beta-TCP, while radiography showed calcified areas. Total bone formation of the combination periosteum and beta-TCP graft was significantly increased compared with single grafts of beta-TCP or periosteum (P < 0.01). The combination graft of periosteum and beta-TCP showed marked bone formation in rat calvarial defects. This result suggests that combination grafts may be effective for repairing bone defects.

Assessment of bone repair in critical-size defect in the calvarium of rats after the implantation of tricalcium phosphate beta (β-TCP)

“…According to Ueno et al, in 7-mm defects in the rat calvarium, β-TCP in combination with autologous tibia periosteum resulted in a higher percentage of new bone formation than did β-TCP alone (50.3 ± 2.5 vs 23.8 ± 1.5) (Ueno et al, 2007). Yun et al carried out a study with a critical-size defects of 8 mm in rat calvaria, and they observed that the subcutaneous use of parathyroid hormone resulted in greater new bone formation than did that of β-TCP alone after four weeks (Yun et al, 2010).…”

Histologic Evaluation of Human Alveolar Sockets Treated With an Artificial Bone Substitute Material

“…These cells promoted proliferation and differentiation of osteoblasts and vascular cells at graft sites and are reportedly closely involved in osteogenesis in β-TCP artificial bone. 1,19 …”

Le périoste vascularisé et la reconstruction osseuse

“…Le diamètre du manchon périostique peut être maintenu par une greffe spongieuse [52] ou par un substitut osseux résorbable [53].…”