The Evaluation of Endothelial Functions in Patients with Celiac Disease

Sarı, Cenk; Bayram, Nihal Akar; Doğan, Fatma Ebru Akın; Baştuğ, Serdal; Bolat, Aylin Demirezer; Sarı, Sevil Özer; Ersoy, Osman; Bozkurt, Engin

doi:10.1111/j.1540-8175.2011.01598.x

Cited by 27 publications

(23 citation statements)

References 29 publications

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“…We found no significant difference between antibody positive and antibody negative patients in terms of PWV and CIMT. Similar results were also observed in two different studies 20,21 .…”

Section: Discussionsupporting

confidence: 79%

“…Although a link between CD and CVD remains weak, it is considered that chronic inflammatory condition in CD may be directly responsible for the development of endothelial dysfunction, leading to a subsequent increase in arterial stiffness and atherosclerotic lesions. A few studies in adults have suggested that CD is associated with premature atherosclerosis [19][20][21] . Endothelial dysfunction at the macrovascular level was found in adult celiac patients 21 .…”

Section: Discussionmentioning

confidence: 99%

“…A few studies in adults have suggested that CD is associated with premature atherosclerosis [19][20][21] . Endothelial dysfunction at the macrovascular level was found in adult celiac patients 21 . Significant increase of cIMT and decreased endotheliumdependent dilatation were found in the young adults with CD compared to the controls; suggesting that they may have accelerated atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

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Carotid intima-media thickness and arterial stiffness as early markers of atherosclerosis in pediatric celiac disease

et al. 2016

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The association between pediatric celiac disease (CD) and atherosclerosis is unknown. Our aim was to investigate whether pediatric CD patients have an increased risk of atherosclerosis. We evaluated the premature atherosclerosis by pulse wave velocity (PWV) and carotid intima-media thickness (cIMT). A total of 37 CD patients (20 girls, mean age 13±3.3 years) and 36 healthy age and sex matched controls were enrolled. Mean duration of CD was 47.1±32.3 months and 40.5% of patients had positive tissue transglutaminase antibody (tTg) IgA. Total cholesterol level was lower in CD (p=0.026) and cIMT was lower in tTg IgA antibody negative CD (p=0.030). cIMT was significantly correlated with tTg IgA antibody positivity (r=0.336; p=0.042). Adherence to strict gluten-free diet is associated with decreased cIMT, suggesting that gluten withdrawal seems to have a beneficial effect on premature atherosclerosis.

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“…We found no significant difference between antibody positive and antibody negative patients in terms of PWV and CIMT. Similar results were also observed in two different studies 20,21 .…”

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Carotid intima-media thickness and arterial stiffness as early markers of atherosclerosis in pediatric celiac disease

et al. 2016

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“…Therefore, because of giving early information about cardiac functions, TDE may be useful to obtain evidence of subclinical impairment of ventricular function. There are few published studies in the pediatric age group with Coeliac disease [31, 32]. Although our results showed a significant difference between the patient and control groups in terms of MV E′ and MV A′ among tissue Doppler echocardiographic parameters of left ventricle, no evidence of diastolic dysfunction was observed.…”

Section: Discussioncontrasting

confidence: 78%

Subclinical Cardiac Dysfunction in Children with Coeliac Disease: Is the Gluten-Free Diet Effective?

Şaylan

Çevik

Kırşaçlıoğlu³

et al. 2012

ISRN Gastroenterology

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Objectives. The aim of this study is to investigate the effects of coeliac disease on cardiac function in children using conventional transthoracic echocardiography (TTE) and tissue Doppler echocardiography (TDE). Methods. Coeliac disease patients were evaluated in two different groups based on serum endomysial antibody (EmA) titers (EmA (+) and EmA (−)), and the data obtained by conventional and TDE studies were compared between the patient groups and healthy controls. Results. There was no significant difference between EmA (+) and EmA (−) groups in terms of the conventional TTE parameters, including ejection fraction (EF), fractional shortening (FS), and left ventricle end diastolic diameter (LVEDD), that show the left ventricular systolic function (P = 0.727, P = 0.317, P = 0.118). TDE showed a significant difference in left ventricle (LV) isovolumic relaxation time (LV IVRT) and LV myocardial performance index (LV MPI) parameters between EmA (+) and EmA (−) patient groups (P < 0.0001). Conclusion. The measurement of LV MPI and LV IVRT parameters by TDE would be beneficial in early determination of the cardiac involvement and establishing appropriate treatment and followup of patients with coeliac disease as well as in making distinction between EmA (+) and EmA (−) patients.

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“…In our previous study, we demonstrated macrovascular endothelial dysfunction in CD patients using a flow-mediated dilatation method [31]. This is the first study to investigate aortic function using echocardiography in CD patients, which revealed deteriorated aortic function.…”

Section: Discussionmentioning

confidence: 99%

Impaired aortic function in patients with coeliac disease

et al. 2015

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A b s t r a c t Background and aim:We aimed to investigate the association between aortic function (aortic stiffness index, aortic strain, and aortic distensibility), which is a predictor of atherosclerosis, and coeliac disease (CD). Methods:Thirty-six patients with CD and 35 control subjects were included in the study. Serological screening was performed to determine the levels of auto-immune markers, including anti-gliadin immunoglobulin (Ig)A and IgG, and anti-tissue transglutaminase antibodies. Aortic distensibility, aortic strain, and aortic stiffness index were calculated using echocardiography. Conclusions:In this study, we showed deteriorated aortic functions by echocardiography in CD patients, which predicted subclinical atherosclerosis. Because deteriorated aortic functions is a strong predictor of future cardiovascular events, close cooperation with cardiologists and gastroenterologists is needed in the management of CD patients, and increased awareness of ischaemic heart disease risk factors in these patients and healthcare providers is warranted.

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The Evaluation of Endothelial Functions in Patients with Celiac Disease

Abstract: This research which aimed to evaluate endothelial dysfunction in patients with celiac disease is the first in the literature. As a result of this study, we found endothelial dysfunction at the macrovascular level in celiac patients.

Cited by 27 publications

References 29 publications

Carotid intima-media thickness and arterial stiffness as early markers of atherosclerosis in pediatric celiac disease

Carotid intima-media thickness and arterial stiffness as early markers of atherosclerosis in pediatric celiac disease

Subclinical Cardiac Dysfunction in Children with Coeliac Disease: Is the Gluten-Free Diet Effective?

Impaired aortic function in patients with coeliac disease

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