The evaluation of Nesfatin-1 levels in patients with OSAS associated with metabolic syndrome

Aksu, Oğuzhan; Aydın, Bünyamin; Doğuç, Duygu Kumbul; İlhan, İlter; Öztürk, Önder; Altuntaş, Atila; Demirkan, Halil; Köroğlu, Banu Kale; Tamer, Mehmet Numan

doi:10.1007/s40618-014-0216-0

Cited by 17 publications

(11 citation statements)

References 22 publications

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“…In the present study, serum nesfatin-1 levels were lower in individuals diagnosed with metabolic syndrome. This result is similar to other studies investigating the metabolic syndrome and its components 21–24 26 27. In the present study, no significant difference was found between the BMI and body fat percentage of the case and control groups.…”

Section: Discussionsupporting

confidence: 92%

Increased hip circumference in individuals with metabolic syndrome affects serum nesfatin-1 levels

Tekin

Çiçek

Konyaligil

et al. 2019

Postgraduate Medical Journal

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BackgroundThis case–control study was conducted to investigate the relationship between serum nesfatin-1 levels and nutritional status and blood parameters in patients diagnosed with metabolic syndrome.MethodsThirty patients (case) diagnosed with metabolic syndrome according to National Cholesterol Education Program-Adult Treatment Panel III criteria were included. Thirty healthy subjects (control) matched with patients with metabolic syndrome in terms of age, gender and body mass index were included. Three-day food consumption records were obtained. Anthropometric indices were measured and body composition was determined by bioelectrical impedance method. Biochemical parameters and serum nesfatin-1 levels were measured after 8 hours of fasting.ResultsSerum nesfatin-1 levels were 0.245±0.272 ng/mL in the case group and 0.528±0.987 ng/mL in the control group (p>0.05). There was a positive significant correlation between serum nesfatin-1 levels and body weight, waist and hip circumferences in the case group (p<0.05). Each unit increase in hip circumference measurement affects the levels of nesfatin by 0.014 times. In the control group, there was a positive significant correlation between body weight and serum nesfatin-1 levels (p<0.05). A significant correlation was detected between HbA1c and serum nesfatin-1 levels in the case group (p<0.05). A significant relationship was detected between dietary fibre intake and the serum nesfatin-1 levels in the case group (p<0.05).ConclusionsAnthropometric indices and blood parameters were correlated with serum nesfatin-1 levels in patients with metabolic syndrome. More clinical trials may be performed to establish the relationship between serum nesfatin-1 levels and nutritional status.

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Section: Discussionsupporting

confidence: 92%

Increased hip circumference in individuals with metabolic syndrome affects serum nesfatin-1 levels

Tekin

Çiçek

Konyaligil

et al. 2019

Postgraduate Medical Journal

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“…It has been shown to stimulate glycose-dependent insulin secretion [28]. Low N1 levels have been reported to be responsible for IR and metabolic syndrome [29]. However, in the organism, the majority of hormones are in equilibrium.…”

Section: Discussionmentioning

confidence: 99%

Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome

Şahin

Ural

et al. 2015

Biomol Biomed

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Polycystic ovary syndrome (PCOS) is one of the most common causes of female infertility. It affects nearly 5-10% of young women. It is characterized by the presence of hirsutism, acne, anovulation, hyperandrogenism, polycystic ovaries, and infertility [1]. Many mechanisms have been reported to be responsible for the pathophysiology of PCOS. The condition is thought to be determined by complex interactions between the hypothalamic-pituitary-ovarian or hypothalamic-pituitary-adrenal axis functions and metabolic disorders, such as obesity, insulin resistance (IR), and compensatory hyperinsulinemia [2]. PCOS increases the prevalence of hyperglycemia, hypertension, and dyslipidemia [3], increasing thus the risk of developing cardiovascular diseases [4].Nesfatin-1 (N1) is derived from nucleobindin 2 (NUCB2), which is encoded by the NUCB2 gene. It is a newly identified peptide that has 82 amino acids [5]. It is released from several tissues including forebrain, hindbrain, brainstem, spinal cord, adipose tissues [6]. It has an anorexigenic effect and plays an important role in hypothalamic pathways such as regulating food intake, energy homeostasis, water intake, and body temperature [7,8]. In addition, it exerts cardiovascular and hypertensive effects [9]. It is closely related to glucose, insulin metabolism, and IR [5,10]. Several studies have demonstrated N1 to be associated with body mass index (BMI), IR, inflammatory stimulation in diabetes, hypertension, and PCOS [9][10][11]. It may also affect the control of the reproduction system, e.g. puberty onset and gonadotropin secretion [12]. ABSTRACTObesity, insulin resistance (IR), inflammation, and hyperandrogenism may lead to polycystic ovary syndrome (PCOS) and hypertension. Nesfatin-1 (N1) may be related to IR, obesity, and hypertension. Furthermore, a vitamin D (VD) deficiency is associated with hypertension and PCOS. We aimed to investigate N1 and VD levels in PCOS that have an effect on systolic and diastolic blood pressure (BP) and heart rate (HR). This study included 54 patients with PCOS and 48 age-body mass index (BMI)-matched healthy controls. PCOS was diagnosed according to clinical practice guidelines. Ferriman-Gallwey scores (FGS) were calculated, while N1, VD, and other hormonal and biochemical parameters were measured for all subjects. Systolic and diastolic BP was measured as well. HR was calculated using an electrocardiogram. The levels of N1 (p < 0.001), high-sensitivity C-reactive protein (hs-CRP) (p = 0.036), homeostasis model assessment as an index of insulin resistance (HOMA-IR) (p < 0.001), systolic (p < 0.001) and diastolic (p < 0.001) BP and HR (p < 0.001) in the PCOS group were significantly higher than in the control group. However, the VD levels of the PCOS group were lower than the control group (p = 0.004). N1 had a strong positive correlation with BMI, HOMA-IR, hs-CRP, luteinizing hormone, systolic and diastolic BP, and HR. VD levels were negatively correlated with HOMA-IR and luteinizing hormone. Elevated N1 and decreased VD levels may...

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“…Besides these few functional studies, in human sleep apnea syndrome an inverse correlation between NUCB2/ nesfatin-1 in peripheral circulation and the severity of disease was observed (Aksu et al 2015, Araz et al 2015, Shen et al 2015, whether there is a functional link remains to be elucidated.…”

Section: Sleepmentioning

confidence: 99%

Nesfatin-1: functions and physiology of a novel regulatory peptide

Dore

Levata

Lehnert

et al. 2017

Journal of Endocrinology

117

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Nesfatin-1 was identified in 2006 as a potent anorexigenic peptide involved in the regulation of homeostatic feeding. It is processed from the precursor-peptide NEFA/ nucleobindin 2 (NUCB2), which is expressed both in the central nervous system as well as in the periphery, from where it can access the brain via non-saturable transmembrane diffusion. In hypothalamus and brainstem, nesfatin-1 recruits the oxytocin, the melancortin and other systems to relay its anorexigenic properties. NUCB2/nesfatin-1 peptide expression in reward-related areas suggests that nesfatin-1 might also be involved in hedonic feeding. Besides its initially discovered anorexigenic properties, over the last years, other important functions of nesfatin-1 have been discovered, many of them related to energy homeostasis, e.g. energy expenditure and glucose homeostasis. Nesfatin-1 is not only affecting these physiological processes but also the alterations of the metabolic state (e.g. fat mass, glycemic state) have an impact on the synthesis and release of NUCB2 and/or nesfatin-1. Furthermore, nesfatin-1 exerts pleiotropic actions at the level of cardiovascular and digestive systems, as well as plays a role in stress response, behavior, sleep and reproduction. Despite the recent advances in nesfatin-1 research, a putative receptor has not been identified and furthermore potentially distinct functions of nesfatin-1 and its precursor NUCB2 have not been dissected yet. To tackle these open questions will be the major objectives of future research to broaden our knowledge on NUCB2/nesfatin-1.

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The evaluation of Nesfatin-1 levels in patients with OSAS associated with metabolic syndrome

Abstract: Nesfatin-1 which is known to play a role in the pathophysiology of insulin resistance can be a beneficial target in developing new therapeutic targets for treatment of patients with obesity without any toxic effects in the future.

Cited by 17 publications

References 22 publications

Increased hip circumference in individuals with metabolic syndrome affects serum nesfatin-1 levels

Increased hip circumference in individuals with metabolic syndrome affects serum nesfatin-1 levels

Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome

Nesfatin-1: functions and physiology of a novel regulatory peptide

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