2022
DOI: 10.1111/aji.13587
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The evaluation of some serum immunochemical markers in early onset pre‐eclamptic women from Algeria

Abstract: Problem: Progress in understanding the underlying mechanism responsible for the syndrome pre-eclampsia should reconfigure antenatal clinical care and minimize human and financial costs, yet at present there is no accurate theory that permits development of reliable predictive tests and prophylactic intervention to mitigate disease. To contribute to this ongoing effort, we aimed to assess various circulating markers pertaining to different theories. Method of study:Serum samples from thirty-four women with esta… Show more

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Cited by 1 publication
(2 citation statements)
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“…The current study detected a significant elevation of blood pressure (BP) measures in all pregnant women, irrespective of reaching the diagnostic levels of pregnancyinduced hypertension (PIH). This finding indicating the hypertensive phenotype of pregnancy and multiple explanations were provided for the coincidence of hypertension and pregnancy, for example, micronutrient deficiencies with or without low levels of immunoglobulins were suggested to be risk factors for the development of high BP up to PE development [20] , gut-placenta axis theory was supposed for the role of gut microbiota dysbiosis and altered levels of their active metabolites for the development of PE [21] , placental malfunction secondary to activation of the RhoA/Rho-kinase pathway to induce overproduction of reactive oxygen species (ROS) by endothelial cells with down-regulation of the cellular HIF1α-UCA1 pathway that promote the trophoblastic adaptation to hypoxia may underlie the development of PIH [22] , disturbed PLGF/sFlet ratio [23] and deregulated expression of vascular endothelial growth factor receptor 2 [24] are also suggested as underlying mechanisms for PIH.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The current study detected a significant elevation of blood pressure (BP) measures in all pregnant women, irrespective of reaching the diagnostic levels of pregnancyinduced hypertension (PIH). This finding indicating the hypertensive phenotype of pregnancy and multiple explanations were provided for the coincidence of hypertension and pregnancy, for example, micronutrient deficiencies with or without low levels of immunoglobulins were suggested to be risk factors for the development of high BP up to PE development [20] , gut-placenta axis theory was supposed for the role of gut microbiota dysbiosis and altered levels of their active metabolites for the development of PE [21] , placental malfunction secondary to activation of the RhoA/Rho-kinase pathway to induce overproduction of reactive oxygen species (ROS) by endothelial cells with down-regulation of the cellular HIF1α-UCA1 pathway that promote the trophoblastic adaptation to hypoxia may underlie the development of PIH [22] , disturbed PLGF/sFlet ratio [23] and deregulated expression of vascular endothelial growth factor receptor 2 [24] are also suggested as underlying mechanisms for PIH.…”
Section: Discussionmentioning
confidence: 99%
“…Pathogenesis of PE was found to be related activation of the inflammatory cascade in direction of inflammation [11] as evidenced by the increased placental number of resting natural killer (NK) and dendritic cells with a reduction in the proportion of activated NK cells [12] . Moreover, aberrant activation of the nuclear factor-Kappa B (NF-κB) pathway, which is a crucial mediator of inflammatory signaling, plays a crucial role in the pathogenesis of several disorders including PE [13] .…”
Section: Introductionmentioning
confidence: 99%