The Evaluation of the Oxidative Stress Parameters in Nondiabetic and Diabetic Senile Cataract Patients

Yıldırım, Zühal; Yildirim, Filiz; Uçgun, Nil İrem; Kılıç, Nedret

doi:10.1007/s12011-008-8258-9

Cited by 25 publications

(19 citation statements)

References 49 publications

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“…We measured MDA concentration as an index of lipid peroxidation using the thiobarbituric acid reaction to verify the oxidant-inflicted damage to plasma and lens. There was a significant increase in MDA concentration in group D compared with group A, in agreement with previous findings in senile cataract [26] , and the MDA concentration in group F was slightly higher than in group D. This indicates increased peroxidation of lipids in group F, and could explain why lens opacity was higher in this group than in group D. The increase in MDA concentration was also consistent with the decrease in GSH in plasma and lens.…”

Section: Discussionsupporting

confidence: 90%

Excessive Milk Intake as a Risk Factor, Probably Associated with Oxidative Stress, in Experimental Naphthalene-Initiated Cataract in Rats

Chen¹,

Jiang²,

Lu³

et al. 2011

Ophthalmic Res

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Aim: To determine whether a diet containing excessive amounts of milk aggravates naphthalene-initiated cataracts in a common animal model of age-related human cataract. Methods: Ninety Sprague-Dawley rats were fed a natural diet supplemented with either water (group A), normal amounts of milk (group B), excessive amounts of milk (group C), naphthalene plus water (group D), naphthalene plus normal amounts of milk (group E), naphthalene plus excessive amounts of milk (group F). Cataract development was monitored weekly using a slit lamp and lens gray value analysis. Concentrations of reactive oxygen species (ROS), reduced glutathione (GSH) and malondialdehyde (MDA) in rat lenses were measured to determine the role of oxidative stress in cataract induction. Results: By week 4, the cortical gray value was significantly higher in group F than that in group D, and the cortical gray value was significantly higher in group D than in group A. However, by week 8, no significant differences were observed among groups C, F, B, E and A. ROS concentrations in lenses of rats of groups C and F were slightly higher than in those of groups B, E and A, but ROS concentrations in group F were significantly higher than in the other groups receiving naphthalene (i.e. groups D and E). GSH concentrations in group F were significantly lower than in the other groups. MDA concentrations in group F were significantly higher than in the other groups receiving naphthalene, indicating increased lipid peroxidation induced by naphthalene plus excessive intake of milk. Conclusions: Our results provide quantitative evidence that excessive intake of milk aggravates naphthalene-initiated cataracts, which is probably due to oxidative damage caused by increased ROS.

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Section: Discussionsupporting

confidence: 90%

Excessive Milk Intake as a Risk Factor, Probably Associated with Oxidative Stress, in Experimental Naphthalene-Initiated Cataract in Rats

Chen¹,

Jiang²,

Lu³

et al. 2011

Ophthalmic Res

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“…reported that the erythrocyte superoxide dismutase levels were significantly lower in advanced senile cataract than those in healthy controls (16). Yildirim et al Found the levels of malondialdehyde (MDA), glutathione (GSh), advanced oxidation protein products (AoPP) and superoxide dismutase (SoD) activities in the diabetic senile cataract group were significantly increased as compared to the nondiabetic senile cataract group (p<0.05) (45). in our study, increased toS and oSi in diabetic cataract patients when compared to senile cataract patients support the result of Yildirim et al and obara et al which reported increased MDA levels and lipid peroxides.…”

Section: Resultsmentioning

confidence: 99%

Oxidant/Antioxidant Status of Patients with Diabetic and Senile Cataract

Aksoy

Gürler

Aksoy³

et al. 2010

Biotechnology & Biotechnological Equipment

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“…Oxidative stress due to enhanced free radical production in diabetics is also considered to be associated with cataract and macular degeneration (59). Moreover, the levels of glutathione, advanced oxidation products, and superoxide dismutase activity in a diabetic senile cataract group are significantly increased compared to the control (non-diabetic) group (75).…”

Section: Retinopathy and Cataractmentioning

confidence: 83%