The Evaluation of the Role of the Cytokines TNF- alfa and IL 6 in the Production of Hypoalbuminemia in Patients Undergoing Major Surgical Interventions

Nicolescu, Cristian; Pop, Alaxendru; Mihu, Alin; Pilat, L; Bedreag, Ovidiu Horea; Nicolescu, Laura

doi:10.37358/rc.18.7.6426

Cited by 8 publications

(8 citation statements)

References 16 publications

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“…It is triggered in the liver by interleukin 1(IL1) and interleukin 6(IL6). This reaction has been proved to be the main mechanism of decreasing the plasmatic level of albumin in patients undergoing major surgery [1,48].These interleukins are particularly produced by the macrophages in the damaged tissue [2,3]. This acute phase reaction belongs to a systemic response, coordinated by interleukins [4].…”

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confidence: 99%

Evaluation of Plasmatic Levels of Negative and Positive Acute Hepatic Phase Proteins in Patients who Underwent Major Surgery

Nicolescu¹,

Totolici²,

Bedreag³

et al. 2019

Rev.Chim.

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The acute hepatic phase response is defined as a reaction that includes hepatic synthesis of proteins, consisting in the increase of some proteins called positive acute phase proteins and the simultaneous decrease of others called negative acute phase proteins. This study describes this hepatic reaction, based on a series of consecutive determinations, at three different time intervals (right before a major surgery event, 24 and 48 hours after the intervention), of the plasmatic levels of transferrin, albumin, fibrinogen and C reactive protein (CRP). Subsequently, the data was analyzed using Jamovi 2019, version 0.9. The inferential statistics consisted in calculating an ANOVA test that compared the values at 24 hours and 48 hours versus the values right before the major surgery. The results were validated by calculating the p value (p[0.05) as well as conducting correlation tests by determining the Pearson coefficient which shows the values of CRP, fibrinogen, transferrin and albumin are independent of each other and do not interact. The multiple ANOVA comparative test reveals the lack of interaction between the values of determined proteins, regardless of the moment of determination.

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confidence: 99%

Evaluation of Plasmatic Levels of Negative and Positive Acute Hepatic Phase Proteins in Patients who Underwent Major Surgery

Nicolescu¹,

Totolici²,

Bedreag³

et al. 2019

Rev.Chim.

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“…Several cytokines and growth factors are known to control the expression of angiogenic factors produced by tumor cells and therefore induce angiogenesis indirectly. The importance of epidermal growth factor receptor (EGFR, ErbB1), HER-2/ErbB2 systems in regulating VEGF and angiogenesis, tumor necrosis factor-alpha (TNF-α), was verified in several tumor systems, including GC [ 28 , 29 , 30 , 31 ].…”

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confidence: 99%

Tumor angiogenesis in gastric cancer

Giubelan,

Stancu,

Honţaru

et al. 2023

Rom J Morphol Embryol

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Gastric cancer (GC) is still a major health problem, being one of the leading causes of cancer-related death in the world. Although the overall incidence of GC is decreasing in the United States and Western Europe, it is still high in many countries from Asia, South America, and Eastern Europe. The process of angiogenesis or the formation of new blood vessels plays an important role in cancer progression, as it allows oxygen supply, nutrients, and factors to grow tumor cells. In our study, we found that gastric neoplasms have high vascularity, with anarchic distribution, uneven in tumor stroma, sometimes with congestion vessels and microhemorrhages. Most vessels were capillaries, with a discontinuous endothelium, poorly structured basement membrane, without junctions between endothelial cells, hyperpermeable, creating the possibility of local edema in the tumor microenvironment (TME), and also extravasation of the plasma, leukocytes and even red blood cells. Angiogenesis vessels showed a low number of pericytes, which shows that they are young vessels, both morphologically and functionally immature. Tumor cells can synthesize biochemical factors [vascular endothelial growth factor-A (VEGF-A)] that stimulate the formation of new vessels (angiogenesis) to ensure their growth and metastasis. Some connective cells (tumor-associated mast cells, tumor-associated fibroblasts) are also involved in the angiogenesis process, which stimulate the progression of tumor cells and remodel the TME.

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“…The study incorporated a comprehensive analysis of variables that extended to patients' demographics and medical history, alongside specific characteristics pertinent to urothelial cancer and cancer management data [32][33][34]. These encompassed patients' age, sex, body mass index, history of substance use, referral form, COVID-19 vaccination status, number of comorbidities, tumoral grading, and duration of hospitalization.…”

Section: Variablesmentioning

confidence: 99%

Pandemic Stressors and Adaptive Responses: A Longitudinal Analysis of the Quality of Life and Psychosocial Dynamics among Urothelial Cancer Patients

Barbos,

Feciche,

Bratosin

et al. 2023

JPM

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The 2019 coronavirus disease (COVID-19) pandemic has had a profound influence on different sectors of society, including health. This study hypothesized a significant impact of the pandemic on the quality of life and psychosocial well-being of urothelial cancer patients, specifically anticipating a decrease in anxiety and depression scores as the pandemic progressed. The primary objectives were to assess longitudinal changes in quality of life indexes, evaluate Healthcare Anxiety and Depression Scale (HADS) score trends over three years (2020–2022), and identify any correlational patterns between the progression of the pandemic and anxiety, depression, and stress levels among this cohort. A cross-sectional analysis was conducted on Eastern Cooperative Oncology Group (ECOG) 1 and Tumor Node Metastasis (TNM) stage 1 bladder cancer patients from the Timis County Emergency Clinical Hospital in Romania. Sixty patients were evaluated each year from 2020 to 2022, utilizing a detailed selection process involving the review of both the hospital database and paper records. Key data included demographic information, medical history, and responses to the Patient Health Questionnaire (PHQ-9), Short Form (SF-36), HADS, and Generalized Anxiety Disorder (GAD-7) questionnaires. A total of 163 completed questionnaires were analyzed, providing insight into various aspects of patients’ experiences during the pandemic. Notably, the mean hospitalization days ranged from 3.6 ± 2.1 days in 2020 to 4.0 ± 2.4 days in 2022 (p = 0.663). Concerns that current symptoms might be pandemic-related spiked to 63.5% in 2021, but reduced to 50.9% in 2022, with this fluctuation being significant (p = 0.026). The perception of decreased quality of or accessibility to medical care was significant over the years, with a decline to 52.7% in 2022 (p = 0.033). Quality of life assessments demonstrated an upward trend, from an average score of 55.9 ± 8.9 in 2020 to 59.3 ± 8.8 in 2022 (p = 0.049). Interestingly, anxiety levels, as indicated by the HADS survey, revealed a significant decline from a score of 7.8 in 2020 to 6.5 in 2022 (p = 0.008). On the other hand, GAD-7 scores displayed a downward trend over the years, potentially indicative of developed coping strategies (p = 0.034). This study provides a comprehensive insight into the fluctuating dynamics of psychosocial factors and quality of life among urothelial cancer patients during the pandemic years. It underscores a potential adaptive response, as evidenced by the decrease in anxiety levels and an upward trend in the quality of life scores over the period. These findings highlight the resilience and adaptability of this patient cohort amidst the challenges posed by the pandemic, potentially guiding future interventions and supports in similar health crises.

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The Evaluation of the Role of the Cytokines TNF- alfa and IL 6 in the Production of Hypoalbuminemia in Patients Undergoing Major Surgical Interventions

Cited by 8 publications

References 16 publications

Evaluation of Plasmatic Levels of Negative and Positive Acute Hepatic Phase Proteins in Patients who Underwent Major Surgery

Evaluation of Plasmatic Levels of Negative and Positive Acute Hepatic Phase Proteins in Patients who Underwent Major Surgery

Tumor angiogenesis in gastric cancer

Pandemic Stressors and Adaptive Responses: A Longitudinal Analysis of the Quality of Life and Psychosocial Dynamics among Urothelial Cancer Patients

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