The evidence for natural therapeutics as potential anti-scarring agents in burn-related scarring

Mehta, M. N.; Branford, Olivier A.; Rolfe, KJ

doi:10.1186/s41038-016-0040-1

Cited by 27 publications

(21 citation statements)

References 156 publications

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“…Resveratrol was discovered to be highly effective in the treatment of numerous types of tumor, including colon cancer, liver cancer and neuroendocrine tumors, as well as inflammatory reaction ( 29 , 30 ). Several previous studies have reported that resveratrol was involved in miRNA-induced autophagy during the treatment of multiple types of disease, such as chronic diabetic nephropathy ( 31 ), Alzheimer's disease ( 32 ) and cancer ( 33 ). For HSs, resveratrol has been approved as a potential agent to suppress scar formation ( 34 ).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis

Pang

Tang

et al. 2020

Mol Med Rep

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Hypertrophic scars (HSs) are a type of pathological scar which are induced by surgery, burn injuries or trauma during the healing process. Due to the high recurrence rates and strong invasive properties, HSs have become a major clinical issue. Resveratrol has been identified as a potential agent to suppress scar formation; however, the underlying mechanism of action remains unclear. Therefore, the present study aimed to investigate the effect of resveratrol on HS-derived fibroblasts (HSFBs) in vitro . MTT assay was performed to evaluate cell viability following the resveratrol treatment. Western blot and RT-qPCR analysis was used to identify the expression levels and the relationship among autophagic markers, miR-4654 and resveratrol treatment. Finally, GFP-LC3 stable HSFBs cells were generated to further assess the effect of resveratrol. The results revealed that resveratrol significantly induced cell death in a dose-dependent manner and induced autophagy by downregulating the expression levels of Rheb in HSFBs. Notably, microRNA-4654 (miR-4654) was significantly decreased in the HSFBs and re-upregulated by resveratrol treatment dose-dependently. Through the bioinformatic analysis and luciferase assay, miR-4654 was identified to directly target Rheb. Transfection studies showed that miR-4654 negative correlated with Rheb expression, suggesting that the autophagic process may be altered by the miR-4654/Rheb axis under the control of resveratrol. In conclusion, the results of the present study suggested that resveratrol may promote autophagy by upregulating miR-4654, which in turn may suppress Rheb expression via directly binding to the 3′-untranslated region of Rheb. These findings provided a novel insight into the development of potential therapeutic targets for HSs.

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Section: Introductionmentioning

confidence: 99%

Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis

Pang

Tang

et al. 2020

Mol Med Rep

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“…Hypertrophic scars are a complex pathologic process which characterized by proliferation of the dermal tissue, excessive deposition of fibroblast-derived ECM over a prolonged period and persistent inflammation and fibrosis [34]. Such pathological scarring can lead to severe functional impairment, psychological morbidity, and costly long term health care [35].…”

Section: Discussionmentioning

confidence: 99%

Effect of Crude Extract and Phytosterol Fraction of Fumaria Officinalis in Induced Hypertrophic Scar of Rabbits

Noori

Abu-Raghif

2019

Asian J Pharm Clin Res

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Objective: The present study aimed to evaluate the role of crude extract and phytosterol fraction of Fumaria officinalis in experimentally induced hypertrophic scar in rabbits. Methods: Surgical wounds were performed on day 1 with an 8‑mm biopsy punch four wounds were created on the ventral surface of the rabbit ear (in vivo) down to cartilage. Triamcinolone acetonide (TAC), crude and phytosterol extracts of F. officinalis L. are administered topically to established scars on day 31. The outcome measures included study of histopathology of skin sections, transforming growth factor beta‑1 (TGF‑β1), level, and collagen three alpha1 in skin tissue. Results: In comparison with the induced hypertrophic scar, all treatment produced a significant reduction in scores of TGFβ1, collagen III, inflammation, and measurement of SEI (p ≤ 0.01). The most significant reduction in inflammation and thickness observed in TAC and extract of crude F. officinalis L. Only crude F. officinalis L. decrease fibroblast counts in comparison to induced hypertrophic scar group and other group (p ≤ 0.05). No statistically significant differences were found between the treatment groups in terms of TGF β1and collagen III. Conclusion: Topical crude extract of F. officinalis L. was more effective in the treatment of induced hypertrophic scar as compared with phytosterol of F. officinalis L. and comparable to the effectiveness of topical TAC.

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“…During wound healing process, the production/synthesis of collagen and GAGs act as a double-edged sword: they enhance the healing process, but excessive production or deposition may result in HS formation. Hence, the balance between degradation and synthesis of collagen plays a vital role in scarring process [18,19]. The contents of collagen (types I & III), hydroxyproline and hexosamine (GAG) were considerably decreased on topical treatment with increasing doses of BA gel (0.2 to 0.6 %).…”

Section: Discussionmentioning

confidence: 99%

Suppressive effect of bacoside A on hypertrophic scar formation by downregulation of TGF-β1

Chen¹,

Lü²

2018

Trop. J. Pharm Res

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Purpose:To determine the anti-scarring property of bacoside A (BA) in a rabbit model of post-burns hypertrophic scar (HS). Methods: A total of 16 healthy male rabbits were divided into four groups (4 rabbits/group). The rabbits were subjected to full-thickness burn wound by placing a 10-mm brass rod at 90 ºC on their ears for 20 s, and were untreated (HS group). The remaining rabbits also underwent HS process but were topically treated daily with 0.2, 0.4 or 0.6 % BA gel (HS + 0.2, 0.4, and 0.6 % BA groups) from day 8 to day 34. Results: The mean values of collagen (types I & III), hydroxyproline (precursor of collagen) and hexosamine, as well as scar index significantly (p < 0.001) decreased after 28 days of topical treatment with BA. Moreover, BA application resulted in improved histological changes with proper arrangement of collagen fibers. Significant (p < 0.001) upregulation or downregulation of transforming growth factor beta-1 (TGF-β1) and matrix metalloproteinase-1 (MMP-1) were observed in the BA-treated rabbits. Conclusion: Treatment with BA significantly lowers the scarring area of burn wounds by downregulation of TGF-β1. Thus, BA can potentially be developed into a drug for managing injury scars. This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest

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The evidence for natural therapeutics as potential anti-scarring agents in burn-related scarring

Cited by 27 publications

References 156 publications

Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis

Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis

Effect of Crude Extract and Phytosterol Fraction of Fumaria Officinalis in Induced Hypertrophic Scar of Rabbits

Suppressive effect of bacoside A on hypertrophic scar formation by downregulation of TGF-β1

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