2005
DOI: 10.1093/brain/awh598
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The evolution and pathology of frontotemporal dementia

Abstract: This is a clinicopathologic study of a prospective, clinic-based cohort of patients with frontotemporal dementia (FTD)/Pick complex, who were followed to autopsy. A total of 60 patients with the clinical syndromes of the behavioural variant of FTD (FTD-bv) (n = 32), primary progressive aphasia (PPA) (n = 22), corticobasal degeneration syndrome (CBDS) (n = 4) and progressive supranuclear palsy (PSP) (n = 2) at onset, referred to a cognitive neurology clinic who had subsequent post-mortem examination were includ… Show more

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Cited by 583 publications
(517 citation statements)
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“…The patient had particularly abnormal BP ND in anterior temporal lobes and ventral anterior cingulate cortex; areas that are particularly prone to tau accumulation in frontotemporal dementia,20 and that were neuropathologically most abnormal in her father.…”
Section: Resultsmentioning
confidence: 95%
“…The patient had particularly abnormal BP ND in anterior temporal lobes and ventral anterior cingulate cortex; areas that are particularly prone to tau accumulation in frontotemporal dementia,20 and that were neuropathologically most abnormal in her father.…”
Section: Resultsmentioning
confidence: 95%
“…Néanmoins, les nombreuses études de cas et surtout les suivis longitudinaux avec confirmation anatomopathologique des AP au sens large ont montré une grande hétérogénéité des tableaux neurolinguistiques et d'importants recouvrements avec d'autres maladies neurodégénératives comme la paralysie supranucléaire progressive (PSP), la dégénérescence corticobasale (DCB), la maladie du motoneurone (MMN), ou encore la démence frontotemporale (DFT) [10][11][12][13]. Ces données, en particulier celles avec suivi longitudinal et autopsie ont révélé que le syndrome langagier peut non seulement précéder, mais également suivre un syndrome neurologique ou neuropsy- …”
Section: L'aphasie Primaire Progressive Ou Syndrome De Mesulamunclassified
“…Em 1892, Arnold Pick descreveu casos clínicos que cursavam com deterioração cognitiva, afasia progressiva e mudanças de conduta social, sendo essas manifestações associadas com a atrofia dos lobos temporais e frontais 1 . Um século depois, os grupos de pesquisa de Lund, na Suécia, e Manchester, na Inglaterra, publicaram crité-rios clínicos e neuropatológicos para o diagnóstico da demência frontotemporal (DFT), que ainda levam em consideração a presença e a distribuição das células (ou corpúsculos) de Pick 2 .…”
Section: Introductionunclassified
“…Outros marcadores, como perdas sinápticas e neuronais nas áreas afetadas podem ter mais correlação com o comprometimento motor e cognitivo 11 . A patologia da DFT pode ser dividida em duas variáveis: Tau positiva ou Tau negativa 1 . O objetivo deste estudo é rever o papel da proteína Tau na patogenia da DFT.…”
Section: Introductionunclassified