The Evolution of Antiviral Therapy for External Ocular Viral Infections Over Twenty-five Years

Yj, Gordon

doi:10.1097/00003226-200009000-00012

Cited by 39 publications

(16 citation statements)

References 55 publications

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“…Publication of studies included in this review peaked during the 1980s (Figure 6), an era of antiviral discovery and investigation (Gordon 2000). After a brief lull, the number of published studies began to rise again after 2005 with the advent of antiviral trials undertaken in China.…”

Section: Discussionmentioning

confidence: 99%

Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis

Wilhelmus

2015

Cochrane Database of Systematic Reviews

107

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Background-Eye disease due to herpes simplex virus (HSV) commonly presents as epithelial keratitis which, though usually self-limiting, may persist or progress without treatment.Objectives-To compare the relative effectiveness of antiviral agents, interferon, and corneal debridement in the treatment of HSV epithelial keratitis. Search methods-We searched CENTRAL (which contains the Cochrane Eyes and Vision

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Section: Discussionmentioning

confidence: 99%

Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis

Wilhelmus

2015

Cochrane Database of Systematic Reviews

107

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“…Clinical trial publications included in this review peaked during the 1980s (Figure 10), an era of antiviral discovery and investigation (Gordon 2000). In comparison, the number of excluded studies slowly rose over time with an upsurge in the early 21st century of trials that studied new antivirals and traditional Chinese medicines (Figure 11).…”

Section: Discussionmentioning

confidence: 99%

Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis

Wilhelmus

2010

Cochrane Database of Systematic Reviews

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“…The therapeutic limitation of these nucleoside analogues is that drug resistant strains develop readily through mutations in the thymidine kinase and/or polymerase viral genes (Alrabiah and Sacks, 1996;Hirsch et al, 1996). For that reason, there is ongoing search for newer topical anti-HSV drugs, alternative to the nucleoside analogs (Cassady and Whitley, 1997;Gordon, 2000).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Action of Meliacine, a Plant-derived Antiviral, on HSV-induced Ocular Disease in Mice

Pifarré

Berra

Coto

et al. 2002

Experimental Eye Research

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Ocular herpes simplex virus type-1 (HSV-1) infections remain an important cause of corneal disease which may result in a loss of vision. Meliacine (MA), an antiviral activity present in crude leaf extracts of Melia azedarach L. that inhibits HSV-1 multiplication in vitro, was studied in a murine herpetic stromal keratitis experimental model. Adult Balb/c mice were inoculated with HSV-1 at their corneas after abrasion. MA was administered topically three times a day for 3 consecutive days, beginning at 24 and 96 hr after infection. Infected animals treated or not with MA were monitored for the development of ocular disease by a binocular microscope for 16 days. MA signi®cantly reduced the incidence and the severity of blepharitis, neovascularization and stromal keratitis with respect to untreated infected mice, regardless the schedule of treatment assayed. Histological examination of corneas from MA-treated animals revealed no tissue damage, whereas corneal samples from untreated infected mice showed in¯ammation, vascularization and necrosis. In uninfected mice treated with MA, we found no evidence of corneal damage and histopathological studies showed no changes in the corneas of these mice. Treatment with MA at 24 hours post-infection (h.p.i.) reduced viral multiplication in the eye by 1±1 . 5 orders of magnitude. Studies on latency revealed that MA sligthly affected the establishment of a latent infection. Thus, MA proved to exert an antiviral action on the development of herpetic stromal keratitis when supplied by post-treatment. Unexpectedly, treatment with MA after 96 h.p.i prevented ocular disease, suggesting an in vivo immunomodulating activity of MA.# 2002 Elsevier Science Ltd.

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The Evolution of Antiviral Therapy for External Ocular Viral Infections Over Twenty-five Years

Abstract: Remarkable progress in the development of antiviral therapy has occurred over the past quarter century. Future needs include improved antivirals and immunomodulators and vaccines to prevent and treat herpetic ocular infections and adenovirus keratoconjunctivitis.

Cited by 39 publications

References 55 publications

Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis

Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis

Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis

Therapeutic Action of Meliacine, a Plant-derived Antiviral, on HSV-induced Ocular Disease in Mice

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