The Evolution of Cirrhosis

Iredale, John P.; Guha, Indra Neil

doi:10.1002/9780470691861.ch6a

Textbook of Hepatology 2007

DOI: 10.1002/9780470691861.ch6a

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The Evolution of Cirrhosis

John P. Iredale¹,

Indra Neil Guha²

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2011

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Cited by 1 publication

References 51 publications

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Targeted Tissue Ablation With Nanosecond Pulses

Long¹,

Shires²,

Plescia

et al. 2011

IEEE Trans. Biomed. Eng.

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In-vivo porcine studies on the effect of nanosecond high voltage pulses on liver tissue have shown that cell death can be induced in well-defined tissue volumes without damaging collagen-predominant structures. Comparison of the experimental results with the results of a three-dimensional finite element model allowed us to determine the threshold electric field for cell death. For 30, 100 nanosecond long pulses this was found to be in the range from 12 to 15 kV/cm. Modelling of the temperature distribution in the tissue using Pennes' bioheat equation showed that the lethal effect of nanosecond pulses on cells is non-thermal. Muscle contractions, generally caused by high voltage pulses, were significantly reduced for the 100 nanosecond pulses compared to microsecond long pulses. The results of these studies indicate that high voltage nanosecond pulses reliably kill normal liver cells in vivo and therefore may be useful for liver tumor treatments.

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Targeted Tissue Ablation With Nanosecond Pulses

Long¹,

Shires²,

Plescia

et al. 2011

IEEE Trans. Biomed. Eng.

View full text Add to dashboard Cite

show abstract

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The Evolution of Cirrhosis

Cited by 1 publication

References 51 publications

Targeted Tissue Ablation With Nanosecond Pulses

Targeted Tissue Ablation With Nanosecond Pulses

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