The evolution of free radicals and oxidative stress

McCord, Joe M.

doi:10.1016/s0002-9343(00)00412-5

Cited by 1,162 publications

(728 citation statements)

References 56 publications

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“…This result is in agreement with our current studies where inhalation of 250 mg or higher resulted in similar levels of MnSOD biochemical activity. McCord and coworkers [47][48][49] have reported that expression of high levels of MnSOD is not beneficial or protective. It is possible that a protective mechanism in the lung may regulate levels of MnSOD.…”

Section: Lung Irradiation Protection By Inhalation Of Mnsod-pl M Carpmentioning

confidence: 99%

Inhalation delivery of manganese superoxide dismutase-plasmid/liposomes protects the murine lung from irradiation damage

et al. 2005

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Intratracheal injection of manganese superoxide dismutaseplasmid/liposome (MnSOD-PL) complexes has been demonstrated to delay the onset and reduce the extent of ionizing irradiation-induced murine pulmonary organizing alveolitis/ fibrosis. To facilitate translation of this modality to clinical fractionated radiotherapy, inhalation delivery of MnSOD-PL was developed using an ultrasonic nebulizer. Transgene product was quantitated by immunohistochemical quantitation and pulmonary tissue levels of MnSOD biochemical activity. C57BL/6NHsd female mice demonstrated a plasmid dose-dependent increased expression of MnSOD transgene product over the range of 250 mg-2.5 mg of MnSOD-PL administered over a constant 5 min interval. Delivery of a constant concentration of 500 mg of MnSOD-PL with varying times of administration ranging from 0.5 to 10 min demonstrated optimal MnSOD expression at 5 min. Mice pretreated by inhalation delivery of MnSOD-PL demonstrated significantly improved survival after 20 Gy single fraction irradiation to both lungs compared to LacZ-PL inhalation-treated or irradiated control mice. Mice receiving 10 fractions of 3.5 cGy demonstrated increased pulmonary MnSOD transgene product activity by a protocol of every Monday-Wednesday or daily inhalation of MnSOD-PL. Thus, inhalation radioprotective gene therapy using MnSOD-PL provides a practical and effective method for delivery of lung-specific radioprotection during fractionated radiotherapy protocols in a mouse model. Gene Therapy (2005) 12, 685-693.

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Section: Lung Irradiation Protection By Inhalation Of Mnsod-pl M Carpmentioning

confidence: 99%

Inhalation delivery of manganese superoxide dismutase-plasmid/liposomes protects the murine lung from irradiation damage

et al. 2005

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“…The activity of SOD in the KD and MK groups was significantly (p < 0.05) lower than that in the WM group in both sexes. Lipid peroxidation is an indicator of oxidative stress in human beings and other organisms (McCord 2000) and it has been proposed as a general mechanism for cell injury and death (Miki et al 1987). MDA is an end product of lipid peroxidation whose formation is accelerated by oxidative stress (Horie et al 1997) and thus detection of MDA can reflect the level of oxygen free radicals and the extent of lipid peroxidation.…”

Section: Resultsmentioning

confidence: 99%

“…Antioxidant enzymes, such as SOD, are widely distributed in all cells (McCord 2000). SOD protects the cell against O 2 -by dismutation of the highly reactive superoxide anion to O 2 (Hseu et al 2008).…”

Section: Resultsmentioning

confidence: 99%

Milk powder induced lipid peroxidation reduction using Ku Ding tea (Lactuca taiwaniana Maxim) in rats

et al. 2010

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The effects of Ku Ding tea (Lactuca taiwaniana Maxim) and milk powder on biochemical and immunological parameters of Sprague-Dawley rats were investigated and the possibility of use of Ku Ding tea to reduce physiological discomfort of drinking milk powder was assessed. Eighty rats were randomly assigned to four treatments: basal diet (control), basal diet plus whole milk powder (WM), basal diet plus Ku Ding tea (KD) and basal diet plus whole milk powder and Ku Ding tea (MK). Data was collected on animals' final body weight, hematological values, blood biochemical parameters, antioxidation parameters and immune organ weight index. Results showed that final body weight of male KD was significantly lower than that of WM. White blood cell count, monocyte count and granulocyte count of KD rats were significantly lower than those of WM. Compared to the control, single milk powder supplementation numerically increased plasma malondialdehyde. The malondialdehyde in the male KD and MK rats were lower than those in WM and control, although the differences were not significant. No significant differences were found in Na + K + -adenosine triphosphatase activity, spleen and thymus index in each group. Consumption of Ku Ding tea appeared to lower lipid peroxidation that was induced by milk powder in the rats.

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“…However, acute thrombotic process, which is an initial part of protective mechanism to fix the lesion, often change to become continuous process because of abundance oxidative stress, and then generates various levels of acute coronary syndromes. 3,5 Several studies showed that acute exercise on treadmill test with high intensity Bruce protocol increased oxidative stress because of ROS. 9,10 On the contrary, acute exercise also increased production of NO because of the increment effect of shear stress on endothelial cells.…”

mentioning

confidence: 99%

“…[1][2][3][4][5] This oxidative stress will cause endothelial lesion and will be responded by endothelial cells through nitric oxide (NO) response and immunological response pathway. 6-8 The immunological response begins by increasing cytokines production, activated coagulation factors, and reactivation of platelet in acute thrombotic process.…”

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confidence: 99%

Effect of Short-Term Low-Intensity Exercise Training on Association of Oxygen Free Radicals and Nitric Oxide Production in Patients with Acute Myocardial Infarction

et al. 2013

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Oxygen, although is highly required for living, can be toxic because it can be easily changed into oxygen free radicals (reactive oxygen species, ROS) and generates oxidative stress. [1][2][3][4][5] This oxidative stress will cause endothelial lesion and will be responded by endothelial cells through nitric oxide (NO) response and immunological response pathway. 6-8 The immunological response begins by increasing cytokines production, activated coagulation factors, and reactivation of platelet in acute thrombotic process. However, acute thrombotic process, which is an initial part of protective mechanism to fix the lesion, often change to become continuous process because of abundance oxidative stress, and then generates various levels of acute coronary syndromes. 3,5 Several studies showed that acute exercise on treadmill test with high intensity Bruce protocol increased oxidative stress because of ROS. 9,10 On the contrary, acute exercise also increased production of NO because of the increment effect of shear stress on endothelial cells. 6,9-15 But, regular exercise Keywords ► acute coronary syndrome ► atherosclerosis ► cardiovascular risk factors ► myocardial infarction ► oxidative stress ► nitric oxide ► cardiac markers ► exercise AbstractModerate-to-high intensity of exercise training within 2 to 3 months decreases oxygen free radicals (reactive oxygen species, ROS) and increases nitric oxide (NO) in outpatients with myocardial infarction. There is no data about the association of ROS and NO after short-term low-intensity exercise training within 5 days in patients hospitalized with acute myocardial infarction (AMI). A total of 32 male patients with AMI were randomized into two groups: 15 patients with short-term low-intensity exercise training within 5 days formed the training group and 17 patients without such exercise training formed the control group. All patients performed exercise treadmill test with modified Bruce protocol before and after the study. F2-isoprostane and NO concentration of the training group increased slightly after modified Bruce exercise treadmill test. Compared with the control group, NO of the training group was also slightly higher. Baseline NO and uric acid were negative predictor variables for F2-isoprostane in all patients hospitalized with AMI, and triglyceride was a positive predictor variable. After the study, physical capacity of the training group was higher; but heart rate and systolic blood pressure were lower significantly. This study showed that short-term low-intensity exercise training for patients hospitalized with AMI did not change ROS and NO productions, but it improved physical capacity and lowered heart rate and systolic blood pressure. NO was negative predictor variable for F2-isoprostane in controlling ROS changes in dynamic compensation mechanism.

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The evolution of free radicals and oxidative stress

Cited by 1,162 publications

References 56 publications

Inhalation delivery of manganese superoxide dismutase-plasmid/liposomes protects the murine lung from irradiation damage

Inhalation delivery of manganese superoxide dismutase-plasmid/liposomes protects the murine lung from irradiation damage

Milk powder induced lipid peroxidation reduction using Ku Ding tea (Lactuca taiwaniana Maxim) in rats

Effect of Short-Term Low-Intensity Exercise Training on Association of Oxygen Free Radicals and Nitric Oxide Production in Patients with Acute Myocardial Infarction

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