The evolution of genes: the chicken preproinsulin gene

Turkish and Japanese Mycobacterium tuberculosis sublineages share a remote common ancestor

“…For macro-organisms, a comfortable but rarely existing situation is to have a series of dated fossils sharing distinctive phenotypes (Ho et al, 2011). For all other situations, common practice is to infer the evolution rate of one molecule and apply it to phylogenies linking present samples (Perler et al, 1980). Inferring DNA evolution rate can be achieved indirectly using a dated fossil, or directly in pedigrees, laboratory lines, or through heterochronous sampling (Ho et al, 2011).…”

Comparison of nucleotide sequences of mRNAs belonging to the mouse H-2 multigene family

“…Data _rocessin: Comparison of sequences has been carried out using Perler's method (18). Biosafety: The work described here was done in accordance with the French guidelines for recombinant DNA research.…”

Structural organization of the rat gene for the arginine vasopressin-neurophysin precursor

“…The other signal, an arginine residue between Np and the glycoprotein, is preserved in exon C. Genes encoding other polyproteins (Herbert, 1981;Numa and Nakanishi, 1981) like the pro-enkephalins (Herbert, 1981;Kakidani et al, 1982;Noda et al, 1982;Gubler et al, 1982;Legon et al, 1982) apparently adopted a mechanism where repetitive enkephalin units together with spacer regions and proteolytic cleavage signals are encoded within a single exon. In these cases pre-existing introns separating the functional units might have been lost during evolution (Perler et al, 1980;Bell et al, 1980) after repetition of an ancestral gene Gubler et al, 1982;Legon et al, 1982). Except for an ancient gene duplication within the neurophysin exon (B), this mechanism does not appear to have played a significant role in the evolution of the AVP-Np gene, which better fits an exon shuffling model (Gilbert, 1978;Crick, 1979).…”