The examination of the coloring mechanism of the human esophageal epithelium by Lugol's solution.

Sawataishi, Masaru; Karaki, Yoshiaki; Kikuchi, Makoto; Saitoh, Mitsukazu; Saeki, Toshio; Yamada, Akira; Shimazaki, Kunihiko; Munakata, Shinya; Sakamoto, Takashi; Shinbo, Takashi; Tazawa, Kenji; Fujimaki, Masao

doi:10.2468/jbes.40.252

Cited by 4 publications

(4 citation statements)

References 1 publication

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“…This reaction does not occur in malignant or dysplastic mucosal epithelial cells due to the lack of glycogen granules in their cytoplasm. They also demonstrated ultrastructurally that glycogen granules in the cells of the esophageal mucosal epithelium decrease with the grade of dysplasia 14 .…”

Section: Discussionmentioning

confidence: 97%

“…This method has been used for the upper gastrointestinal tract 1,6,11,12,14,16 and oral mucosal lesions 4,7 . In an analysis of 147 patients with esophageal carcinoma, Lugol's iodine staining was useful for detecting groups at high risk of multicentric cancer in the upper aerodigestive tract 12 .…”

Section: Discussionmentioning

confidence: 99%

“…Surg. 2011; 40: 593-596 doi:10.1016/j.ijom.2010.11.026, available online at http://www.sciencedirect.com in the diagnosis of epithelial dysplasia 1,4,6,11,12,14,15,22 , but it has not been well documented whether the use of staining decreased local recurrence after OSCC surgery. In this study, the local recurrence rate in patients with early tongue cancer who underwent surgery using iodine staining during surgery was investigated.…”

mentioning

confidence: 98%

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Clinical evaluation of Lugol's iodine staining in the treatment of stage I–II squamous cell carcinoma of the tongue

Umeda

Satō

Takahashi

et al. 2011

International Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 98%

See 1 more Smart Citation

Clinical evaluation of Lugol's iodine staining in the treatment of stage I–II squamous cell carcinoma of the tongue

Umeda

Satō

Takahashi

et al. 2011

International Journal of Oral and Maxillofacial Surgery

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“…In the use of iodine staining to diagnose oral lesions, the iodine monad is absorbed by a spiral of one amylase which constitutes a normal chain portion of starch existing in the cytoplasm, and the reaction is visualized as a brown color (20). Sawataishi et al (21) reported that glycogen in cells of the esophageal mucosa react with iodine. This reaction does not occur in dysplastic mucosa, due to the lack of glycogen granules in the cytoplasm of these cells.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of a fluorescence visualization system for the detection of oral precancerous and early cancerous lesions

et al. 2016

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Abstract. Early detection of precancerous and early cancerous lesions could greatly reduce both the mortality and morbidity of oral cancer. The objective of this study was to analyze a fluorescence visualization (FV) system for the detection of precancerous and early cancerous lesions in rat tongue carcinogenesis and human oral cancerous lesions using for the first time a 4NQO rat model and human tissue. Based on the results from the rat tongue carcinogenesis model, under direct FV, the normal oral mucosa emitted various shades of pale green autofluorescence. In the precancerous and early cancerous cases, the lesion appeared as an irregular dark area. Histological examination of the lesions showed that the VELscope system had a sensitivity of 95% and specificity of 100% in discriminating normal mucosa from dysplasia/ carcinoma in situ (CIS) or invasive carcinoma. The proliferating cell nuclear antigen (PCNA) protein level was gradually increased with progression of carcinogenic transformation. Furthermore, the results of PCNA and FV loss (FVL) were correlated. Next, results from 17 patients were also presented. Histological examination of the lesions showed that the VELscope system had a sensitivity of 95% and specificity of 100% in discriminating normal mucosa from severe dysplasia/ CIS or invasive carcinoma. There were no normal epithelium cells in any of the FVL regions. Furthermore, to clarify the usefulness of FV compared to vital staining with iodine, we investigated the surgical margins of early oral squamous cell carcinoma (OSCC) tissues and compared the FVL and iodine unstained area (IU). The percentage of various types of dysplasia were almost equal when comparing the FVL and IU. These results suggest that this direct FV device has the potential for simple, cost-effective screening, detection and margin determination of oral precancerous and early cancerous lesions. IntroductionSquamous cell carcinoma (SCC) is the most frequent type of cancer in the oral and maxillofacial region, and its metastatic and invasive abilities result in a poor prognosis (1,2). Standard care for oral cancer includes a combination of surgery, radiation and chemotherapy. Although cancer treatment is progressing substantially, the survival rate of patients with oral cancer has not changed over the past 30 years (3). Early detection of premalignant oral mucosal abnormalities and SCC is preferred because early diagnosis and appropriate treatment decrease patient morbidity and improve survival (4). The clinical symptoms of precancerous lesions and early oral squamous cell carcinoma (OSCC) are varied and may be misdiagnosed as other conditions, including mucosal inflammation, hyperkeratosis, or traumatic ulceration.Autofluorescence is one potential technique that may be used to facilitate the visualization and detection of oral precancerous and early cancerous lesions. As early as 1924, it was discovered that the autofluorescence of tissues could potentially be used for cancer detection. Autofluorescence works on the principle that ...

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Cell proliferation and tumour suppressor gene expression in iodine unstained area surrounding oral squamous cell carcinoma

Yokoo

Noma

Inoue

et al. 2004

International Journal of Oral and Maxillofacial Surgery

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The examination of the coloring mechanism of the human esophageal epithelium by Lugol's solution.

Cited by 4 publications

References 1 publication

Clinical evaluation of Lugol's iodine staining in the treatment of stage I–II squamous cell carcinoma of the tongue

Clinical evaluation of Lugol's iodine staining in the treatment of stage I–II squamous cell carcinoma of the tongue

Usefulness of a fluorescence visualization system for the detection of oral precancerous and early cancerous lesions

Cell proliferation and tumour suppressor gene expression in iodine unstained area surrounding oral squamous cell carcinoma

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