The Excretion of Hippuric Acid in Subjects With Free Anxiety

Persky, Harold; Grinker, Roy R.; Mirsky, I. Arthur

doi:10.1172/jci102226

Cited by 22 publications

(13 citation statements)

References 8 publications

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“…It was also observed that in the same normal subjects on separate occasions a constant PAH synthesis in terms of %o of the normal mean was maintained in spite of variation in total PAB + PAH. The finding of increased PAH synthesis in two patients with severe anxiety states is in accord with the reported increased hippuric acid excretion in such patients (10).…”

Section: Discussionsupporting

confidence: 88%

Studies in Para-Aminohippuric Acid Synthesis in the Human: Its Application as a Liver Function Test

Deiss¹,

Cohen²

1950

J. Clin. Invest.

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Section: Discussionsupporting

confidence: 88%

Studies in Para-Aminohippuric Acid Synthesis in the Human: Its Application as a Liver Function Test

Deiss¹,

Cohen²

1950

J. Clin. Invest.

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“…As a result of training the GSH level fell significantly, but as in the case of the jump from the 34-foot tower, the rise in GSSG was not commensurate (Table 6). It was felt that the men in this group did not develop free anxiety of the intensity reported elsewhere, 19 since the hippuric acid production of matched subjects under identical conditions did not rise, an index which has been shown to be closely correlated with free anxiety. 18 …”

Section: Night Infiltrationmentioning

confidence: 60%

Glutathione Metabolism in Men under Psychological Stress

Persky

1954

Psychosomatic Medicine

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“…Because of the uniquely small size of glycine residues, relative to those derived from other amino acids, the high concentrations of glycine in collagen and elastin have often been thought significant in influencing the characteristic configurations and modes of packing of the polypeptide chains in these fibrous proteins (38,39 (40,41). Many of our rheumatoid patients showed chronic anxiety, and the early cases in Stage I excreted more hippurate than did controls or those with more advanced disease (Table III).…”

Section: Discussionmentioning

confidence: 99%

Abnormal Glycine Metabolism in Rheumatoid Arthritis

Lemon¹,

Chasen²,

Looney³

1952

J. Clin. Invest.

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Connective tissue is considered to be composed of tightly folded polypeptide chains, resting in an extracellular amorphous ground substance consisting of polymerized muco-polysaccharides. As a result of the pioneering investigations of Meyer(1) and Duran-Reynals (2), considerable investigation has been carried out concerning alterations in composition and permeability of the ground substance in diseases affecting connective tissues (3). Alterations in the polypeptide chains responsible for the tensile strength and elasticity of connective tissue, however, have not yet been adequately studied in these diseases, nor is there any information available concerning the factors responsible for maintaining the integrity of this widely prevalent extracellular protein network. Methods suitable for clinical investigation have been lacking for investigation of this problem. We wish to report an adaptation of the hippuric acid liver function test devised by Quick (4), which has revealed in patients with active rheumatoid arthritis abnormal metabolism of at least one of the major amino acid components of collagen. These patients fail to maintain their serum glycine within 15 per cent of the fasting value after the administration of 1.77 gm. sodium benzoate intravenously.The basis for our observations rests upon the unique chemical composition of the proteins, collagen and elastin. Glycine constitutes 22.8 to 27.6 per cent by weight of these substances, accounting for approximately one-third of the total 1 Consultant, internal medicine research, Boston Regional Office, Veterans Administration; assistant Professor of Medicine, Boston University School of Medicine.2 Chief, Arthritis Clinic, Boston Regional Office, Veterans Administration.

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The Excretion of Hippuric Acid in Subjects With Free Anxiety

Cited by 22 publications

References 8 publications

Studies in Para-Aminohippuric Acid Synthesis in the Human: Its Application as a Liver Function Test

Studies in Para-Aminohippuric Acid Synthesis in the Human: Its Application as a Liver Function Test

Glutathione Metabolism in Men under Psychological Stress

Abnormal Glycine Metabolism in Rheumatoid Arthritis

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