This study is about getting some conditions that guarantee the existence and uniqueness of the weighted pseudo almost periodic (WPAP) solutions of Mackey-Glass with time-varying delays. Some adequate conditions have been obtained for the existence and uniqueness of the WPAP solutions of the Mackey-Glass, which we dealt with using some differential equation inequalities, the WPAP theory, and the Banach fixed-point theorem. Besides, an example is given to demonstrate the accuracy of the conditions of our main results.