The expanding clinical spectrum of ocular lyme borreliosis

Mikkilä, Helena; Seppälä, Ilkka; Viljanen, Matti K.; Peltomaa, Miikka; Karma, Alain

doi:10.1016/s0161-6420(99)00128-1

Cited by 165 publications

(93 citation statements)

References 25 publications

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“…The use of molecular diagnostic techniques could be useful in understanding the aetiopathogenesis of Eales' disease. [48][49][50] We hypothesize that a common protein sequence acts as an antigenic stimulus for an immune cascade that results in perivasculitis characteristic of Eales' disease. Prospective studies are needed in arriving at the common sequence that is responsible for triggering such an immune cascade.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of epiretinal membranes associated with Eales' disease: a clinicopathologic evaluation

Majji

Vemuganti

Shah

et al. 2005

Eye

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Section: Discussionmentioning

confidence: 99%

A comparative study of epiretinal membranes associated with Eales' disease: a clinicopathologic evaluation

Majji

Vemuganti

Shah

et al. 2005

Eye

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“…Previous reports described impaired immune response in uveitis patients with confirmed diagnosis of Lyme disease (Dattwyler et al 1988). The ophthalmic manifestations of Lyme borreliosis represent a spectrum that includes ocular inflammatory conditions (conjunctivitis, episcleritis, interstitial keratitis, uveitis and retinal vasculitis), neuro-ophthalmic involvement (cranial neuropathies such as facial nerve palsy, optic neuritis and optic disc oedema) and orbital pathology (orbital myositis) (Mikkila et al 2000). Many of these clinical features are also characteristic of syphilitic eye involvement.…”

Section: Discussionmentioning

confidence: 99%

“…The spectrum of ocular borreliosis includes episcleritis, interstitial keratitis, anterior uveitis, vitritis, choroiditis, retinal vasculitis, optic neuritis and papilloedema (Mikkila et al 2000). We herein report on the occurrence of inflammatory choroidal neovascular membrane (CNVM) in two patients suffering from presumed Lyme disease.…”

Section: Introductionmentioning

confidence: 95%

Inflammatory choroidal neovascular membrane in presumed ocular Lyme borreliosis

Amer

Brannan

Forrester

2009

Acta Ophthalmologica

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. Introduction: Lyme disease is a multisystemic disease with protean ocular manifestations. We describe the occurrence of inflammatory choroidal neovascular membrane (CNVM) in two patients suffering from presumed Lyme disease. Methods: Descriptive review of the clinical records of two patients. Results: Patient 1: 16‐year‐old healthy male presenting with a visual acuity of counting fingers [oculus dexter (OD)] and 6/6 [oculus sinister (OS)] 3 months after a tick bite. He had papillitis and an exudative subretinal macular lesion OD. Treatment was started with intravenous (IV) ceftriaxone; a week later, IV methylprednisolone was administered with a tapering dose of oral steroids thereafter. Three months later, VA had improved to 3/60 OD. Patient 2: 38‐year‐old healthy female presenting with reduced left‐eye vision (6/24) 6 weeks after a tick bite. She also suffered from erythema migrans and arthralgias. She had left‐eye papillitis, macular haemorrhages and vascular sheathing. Treatment was started with IV ceftriaxone. One month later, there was profound loss of vision with development of CNVM. Treatment was declined by the patient and eventually retinal fibrosis developed. Conclusion: Inflammatory CNVM has not been described previously in the setting of ocular Lyme borreliosis. We herein describe the occurrence of inflammatory CNVM in two patients whose diagnosis with Lyme disease was clinically based – both were sero‐negative. Visual outcome in the two patients was profoundly impaired because of the ensuing macular scar.

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“…Uveitis rarely occurs in Lyme disease, but when it does the findings are protean. As with syphilis, ocular Lyme has been associated with anterior uveitis, intermediate uveitis, optic neuritis, neuroretinitis, retinal vasculitis, choroiditis, and panuveitis, Uveitis is usually seen in the late stage of Lyme disease [40,41]. Novel Infectious Agents of uveitis.These include: Leptospirosis, Brucellosis, Leprosy, Whipple's disease, Propinobacterium acne, Cat-scratch disease, West Nile virus, Candida spp , and Histoplasmosis.…”

Section: Clinical Presentations and Etiologymentioning

confidence: 99%