The expanding Pandora’s toolbox of CD8+T cell: from transcriptional control to metabolic firing

Wu, Jinghong; Lu, Zhendong; Zhao, Hong; Lu, Mingjun; Gao, Qing; Che, Nanying; Wang, Jinghui; Ma, Teng

doi:10.1186/s12967-023-04775-3

Cited by 2 publications

(1 citation statement)

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“…This process is intricately regulated by various cell types, including CD4 T cells, which contribute to establishing optimal niches for the development and maintenance of effective CD8 T cell immunity ( 36 ). Effector CD8 T cells migrate to primary sites of infection or tumors, where they secrete cytokines such as IFNγ and effector molecules like perforin and granzyme, aimed at specifically eliminating the target cells in situ ( 37 ). Most of these acute effector CD8 T cells are eventually eliminated following antigen clearance, leading to the formation of a residual pool of diverse memory cells ( 38 ).…”

Section: Introductionmentioning

confidence: 99%

CD8 T cells are dispensable for experimental autoimmune prostatitis induction and chronic pelvic pain development

Salazar,

Martinez,

Paira

et al. 2024

Front. Immunol.

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IntroductionChronic Pelvic Pain Syndrome or Chronic Prostatitis (CPPS/CP) is the most prevalent urologic affliction among young adult men. It is a challenging condition to treat, which significantly decreases patient quality of life, mostly because of its still uncertain aetiology. In that regard, an autoimmune origin is a prominent supported theory. Indeed, studies in patients and in rodent models of Experimental Autoimmune Prostatitis (EAP) have provided compelling evidence suggesting a key role of CD4 Th1 cells in disease pathogenesis. However, the implication of other prominent effectors of the immune system, such as CD8 T cells, has yet to be studied.MethodsWe herein analyzed the induction of prostatitis and the development of chronic pelvic pain in EAP using CD8 T cell-deficient animals.ResultsWe found similarly elevated PA-specific immune responses, with high frequencies of specific IFNg+CD4+ and IL17+CD4+ T cells in prostate draining lymph nodes from PA-immunized either CD8 KO or wild type animals with respect to controls. Moreover, these peripheral immune responses were paralleled by the development of significant chronic pelvic pain, and accompanied by prostate histological lesions, characterized by hemorrhage, epithelial cell desquamation, marked periglandular leukocyte infiltration, and increased collagen deposition in both, PA-immunized CD8 KO and wild type animals. As expected, control animals did not develop prostate histological lesions.DiscussionOur results indicate that CD8 T cells do not play a major role in EAP pathogenesis and chronic pelvic pain development. Moreover, our results corroborate the previous notion that a CD4 Th1 associated immune response drives the induction of prostate tissue inflammation and the development of chronic pelvic pain.

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Section: Introductionmentioning

confidence: 99%