The Expanding Spectrum of Zika Virus Infections of the Nervous System

Tyler, Kenneth L.; Roos, Karen L.

doi:10.1001/jamaneurol.2017.1471

Cited by 13 publications

(20 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The demonstration that the infection yields increased levels of IgG4 during pregnancy is relevant since IgG4 autoimmune antibodies against different antigens are found in various autoimmune diseases and neurological disorders, including GBS ( 33 , 34 ). Although the disease mechanism of GBS after ZIKV infection may be very different than in GBS after other infections, our study shows an increase in total ganglioside and anti-GD3 antibodies in Zika patients and points out that it may be related to the broad neuropathy associated with the disease ( 35 ).…”

Section: Discussionmentioning

confidence: 57%

Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection

et al. 2018

View full text Add to dashboard Cite

Zika virus (ZIKV) disease has become a global health emergency with devastating effects on public health. Recent evidences implicate the virus as an emergent neuropathological agent promoting serious pathologies of the human nervous system, that include destructive and malformation consequences such as development of ocular and fetal brain lesions, microcephaly in neonates, and Guillain–Barré syndrome (GBS) in adults. These neurological disorders of both central and peripheral nervous systems are thought to be associated to the neurotropic properties of the virus that has ability to infect neural stem cells as well as peripheral neurons, a hallmark of its pathogenicity. The presence of autoantibodies against gangliosides plays a pivotal role in the etiogenesis of GBS and a variety of neurological disorders. Gangliosides are a class of galactose-containing cerebrosides mainly expressed in nervous system tissues playing a critical role in the physiology of neural cells and neurogenesis. Herein, our findings indicate that patients at acute phase of ZIKV infection without any neurological signs show increased levels of IgG autoantibody against GD3 gangliosides, a class of glycolipid found to be highly expressed in neural stem cell acting in the maintenance of their self-renewal cellular capacity. It is possible that a pathological threshold of these antibodies is only acquired in secondary or subsequent infections. In the light of these evidences, we propose that the target of GD3 by autoimmune responses may possibly has an effect in the neuropathy and neurogenesis disorder seen during ZIKV infection.

show abstract

Section: Discussionmentioning

confidence: 57%

Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection

et al. 2018

View full text Add to dashboard Cite

show abstract

“…CNS infections related to ZIKV have been described, and not only in foetuses [4], [6], [25]. In Brazil, a single case of encephalitis was described in an 8-year-old child with ZIKV infection and reactivation of varicella zoster virus.…”

Section: Flaviviruses As Aetiologic Agents Of Cns Infectionsmentioning

confidence: 99%

“…Serology for the detection of virus-specific IgM in CSF is used as an adjunct method [10]. Serology is commonly used to diagnose viruses in the CNS, including flaviviruses, because virus-specific IgM in CSF shows intrathecal synthesis and is considered to reflect viral target antigens within the CNS, as IgM does not cross the blood–brain barrier [4], [33].…”

Section: Laboratory Diagnosismentioning

confidence: 99%

“…Just like the Japanese encephalitis virus, some representatives of the Flavivirus genus (family Flaviviridae ) are transmitted by mosquitoes and are classically classified as neurotropic viruses, including West Nile virus (WNV) and St Louis encephalitis virus (SLEV) [4]. However, in recent years, other members of this genus, primarily dengue virus (DENV) and Zika virus (ZIKV), have been associated with CNS infections [4], [5], [6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Flaviviruses as agents of childhood central nervous system infections in Brazil

Marinho

Kroon

2019

New Microbes and New Infections

View full text Add to dashboard Cite

Flaviviruses are agents of a major emerging human public health issue, and members of the Flavivirus genus have been associated with central nervous system (CNS) infections. In Brazil, a country endemic for some arboviruses, the most clinically relevant neurotropic flaviviruses include dengue virus and Zika virus. Flaviviruses cause diseases ranging from mild or subclinical infections to severe cases as CNS infections. There is a lack of data about the incidence of flaviviruses in the CNS of children in Brazil. In this review, we provide a general overview of several flaviviruses that cause CNS infections in Brazilian children and explore the importance of epidemiologic surveillance of CNS infections in cases of Flavivirus infections.

show abstract

“…For that reason, men diagnosed with ZIKV infection should avoid attempting conception for at least six months and keep systematic use of condoms in all sexual intercourses in this period. The high rate of asymptomatic infection following ZIKV infection, estimated in 80% of infected individuals [ 116 ], leads to a gross underestimation of the risk for sexual transmission.…”

Section: Interactions Of Zikv In the Male Reproductive Tractmentioning

confidence: 99%

Zika Virus Trafficking and Interactions in the Human Male Reproductive Tract

Silva

2018

Pathogens

View full text Add to dashboard Cite

Sexual transmission of Zika virus (ZIKV) is a matter of great concern. Infectious viral particles can be shed in semen for as long as six months after infection and can be transferred to male and female sexual partners during unprotected sexual intercourse. The virus can be found inside spermatozoa and could be directly transferred to the oocyte during fertilization. Sexual transmission of ZIKV can contribute to the rise in number of infected individuals in endemic areas as well as in countries where the mosquito vector does not thrive. There is also the possibility, as has been demonstrated in mouse models, that the vaginal deposition of ZIKV particles present in semen could lead to congenital syndrome. In this paper, we review the current literature to understand ZIKV trafficking from the bloodstream to the human male reproductive tract and viral interactions with host cells in interstitial spaces, tubule walls, annexed glands and semen. We hope to highlight gaps to be filled by future research and potential routes for vaccine and antiviral development.

show abstract

The Expanding Spectrum of Zika Virus Infections of the Nervous System

Cited by 13 publications

References 17 publications

Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection

Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection

Flaviviruses as agents of childhood central nervous system infections in Brazil

Zika Virus Trafficking and Interactions in the Human Male Reproductive Tract

Contact Info

Product

Resources

About